Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

(2021) Ning Huang et al.   CURRENT BIOLOGY

Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

(2021) Kelly A. Chamberlain et al.   NEURON

Synaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model

(2020) Balázs A. Györffy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction

(2020) Tyler G. Demarest et al.   ACTA NEUROPATHOLOGICA

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

(2020) Orla Watters et al.   JOURNAL OF NEUROSCIENCE

Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation

(2020) Wenzhong Yang et al.   MOLECULAR PSYCHIATRY

Mitochondrial protein biogenesis in the synapse is supported by local translation

(2020) Bozena Kuzniewska et al.   EMBO REPORTS

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons

(2020) Sandra Harjuhaahto et al.   NEUROBIOLOGY OF DISEASE

Glucose transporters in brain in health and disease

(2020) Hermann Koepsell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

(2020) Rodrigo A. Quintanilla et al.   Frontiers in Cellular Neuroscience

Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse

(2020) Mohannad A. Almikhlafi et al.   Scientific Reports

DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner

(2020) Rosalind Norkett et al.   Frontiers in Cell and Developmental Biology

Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure

(2020) Jan-Oliver Hollnagel et al.   iScience

Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

(2020) César Espino de la Fuente-Muñoz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inter‐spike mitochondrial Ca 2+ release enhances high frequency synaptic transmission

(2020) Che Ho Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

(2019) Mark A. Lobas et al.   Nature Communications

Quantitative Proteomics of Presynaptic Mitochondria Reveal an Overexpression and Biological Relevance of Neuronal MitoNEET in Postnatal Brain Development

(2019) Kelly L. Stauch et al.   Developmental Neurobiology

The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria

(2019) Amos Gutnick et al.   NATURE CELL BIOLOGY

Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment

(2019) Alejandra Fernandez et al.   NEURON

Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

(2019) Ernesto Manzo et al.   eLife

Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

(2019) Rajat Puri et al.   Nature Communications

Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

(2019) Ghazaleh Ashrafi et al.   NEURON

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

(2019) Angelo Iannielli et al.   Cell Reports

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

(2019) Raphael Hesse et al.   Acta Neuropathologica Communications

FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons

(2018) James B. Machamer et al.   BRAIN RESEARCH

A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons

(2018) Alessio Vagnoni et al.   CURRENT BIOLOGY

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution

(2018) Guillermo López‐Doménech et al.   EMBO JOURNAL

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

Evidence for compartmentalized axonal mitochondrial biogenesis: Mitochondrial DNA replication increases in distal axons as an early response to Parkinson's disease-relevant stress

(2018) Victor S. Van Laar et al.   JOURNAL OF NEUROSCIENCE

Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

(2018) Sarah J. Lucas et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Characterization of the Mitochondrial Aerobic Metabolism in the Pre- and Perisynaptic Districts of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2018) Silvia Ravera et al.   MOLECULAR NEUROBIOLOGY

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

(2018) Sirui Jiang et al.   Molecular Neurodegeneration

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Ca 2+ Sensor for Exocytosis

(2018) Edwin R. Chapman   TRENDS IN NEUROSCIENCES

Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution

(2018) Tatiana Trevisan et al.   Cell Reports

Reconstituting Corticostriatal Network on-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington’s Disease

(2018) Amandine Virlogeux et al.   Cell Reports

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease

(2018) Eleanor K. Pickett et al.   ACTA NEUROPATHOLOGICA

Early Selective Vulnerability of Synapses and Synaptic Mitochondria in the Hippocampal CA1 Region of the Tg2576 Mouse Model of Alzheimer's Disease

(2018) Marta Balietti et al.   JOURNAL OF ALZHEIMERS DISEASE

Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Vera F. Monteiro-Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

Presynaptic loss of dynamin‐related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of Held

(2018) Mahendra Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Towards an Understanding of Synapse Formation

(2018) Thomas C. Südhof   NEURON

Mitochondria modulate programmed neuritic retraction

(2018) Sergei V. Baranov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size

(2018) Tommy L. Lewis et al.   Nature Communications

Differential Presynaptic ATP Supply for Basal and High-Demand Transmission

(2017) Courtney Sobieski et al.   JOURNAL OF NEUROSCIENCE

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Use of luciferase probes to measure ATP in living cells and animals

(2017) Giampaolo Morciano et al.   Nature Protocols

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

(2017) Catherine M Drerup et al.   eLife

Mitochondrial Amyloid-β Levels are Associated with the Extent of Mitochondrial Dysfunction in Different Brain Regions and the Degree of Cognitive Impairment in Alzheimer's Transgenic Mice

(2017) Natasa Dragicevic et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

(2016) Rigel J. Kishton et al.   Cell Metabolism

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

HFS-Triggered AMPK Activation Phosphorylates GSK3β and Induces E-LTP in Rat HippocampusIn Vivo

(2016) Dan-Fang Yu et al.   CNS Neuroscience & Therapeutics

Mitochondrial Dynamics in Visual Cortex Are Limited In Vivo and Not Affected by Axonal Structural Plasticity

(2016) Laura Smit-Rigter et al.   CURRENT BIOLOGY

Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo

(2016) Tommy L. Lewis et al.   CURRENT BIOLOGY

Miro1‐dependent mitochondrial positioning drives the rescaling of presynaptic Ca 2+ signals during homeostatic plasticity

(2016) Victoria Vaccaro et al.   EMBO REPORTS

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease

(2016) Pamela V Martino Adami et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Glycolysis selectively shapes the presynaptic action potential waveform

(2016) Brendan Lujan et al.   JOURNAL OF NEUROPHYSIOLOGY

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

(2016) N. S. Morsci et al.   JOURNAL OF NEUROSCIENCE

Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo

(2016) H. Sung et al.   JOURNAL OF NEUROSCIENCE

Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle

(2016) Joachim Nielsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial Proteome Changes Correlating with β-Amyloid Accumulation

(2016) Katalin Völgyi et al.   MOLECULAR NEUROBIOLOGY

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

(2016) Dong Kong et al.   NEURON

Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function

(2016) SoRi Jang et al.   NEURON

Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration

(2016) Kelly L. Stauch et al.   Proteomics Clinical Applications

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

(2016) María-Victoria Hinckelmann et al.   Nature Communications

Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites

(2016) Guillermo López-Doménech et al.   Cell Reports

Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex

(2016) Darius Ebrahimi-Fakhari et al.   Cell Reports

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

(2015) B Oettinghaus et al.   CELL DEATH AND DIFFERENTIATION

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

(2015) Divya Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A marginal band of microtubules transports and organizes mitochondria in retinal bipolar synaptic terminals

(2015) Malkolm Graffe et al.   JOURNAL OF GENERAL PHYSIOLOGY

ATP Binding to Synaspsin IIa Regulates Usage and Clustering of Vesicles in Terminals of Hippocampal Neurons

(2015) Y. Shulman et al.   JOURNAL OF NEUROSCIENCE

The Organization of Mitochondrial Quality Control and Life Cycle in the Nervous System In Vivo in the Absence of PINK1

(2015) S. Devireddy et al.   JOURNAL OF NEUROSCIENCE

The regulation of neuronal mitochondrial metabolism by calcium

(2015) I. Llorente-Folch et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptic mitochondria: A brain mitochondria cluster with a specific proteome

(2015) Katalin Völgyi et al.   Journal of Proteomics

Books in brief

(2015) Barbara Kiser   NATURE

Optogenetic control of organelle transport and positioning

(2015) Petra van Bergeijk et al.   NATURE

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate

(2015) Sofie C. Lange et al.   NEUROCHEMICAL RESEARCH

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia

(2015) R.C. Roberts et al.   SCHIZOPHRENIA RESEARCH

Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons

(2015) L Y Shields et al.   Cell Death & Disease

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

(2015) Nicol Birsa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

(2014) Sylvie Bannwarth et al.   BRAIN

Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase

(2014) Gulcin Pekkurnaz et al.   CELL

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons

(2014) A. Berthet et al.   JOURNAL OF NEUROSCIENCE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease

(2014) T. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

(2013) Diana Zala et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

AMP-activated protein kinase mediates activity-dependent axon branching by recruiting mitochondria to axon

(2013) Kentaro Tao et al.   Developmental Neurobiology

Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon

(2013) Kazuki Obashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Kinesin-1–syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport

(2013) Yanmin Chen et al.   JOURNAL OF CELL BIOLOGY

Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy

(2013) Fahmeed Hyder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Cytosolic Calcium Coordinates Mitochondrial Energy Metabolism with Presynaptic Activity

(2012) A. K. Chouhan et al.   JOURNAL OF NEUROSCIENCE

The Energetics of CNS White Matter

(2012) J. J. Harris et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

(2012) Eugenia Trushina et al.   PLoS One

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Ca2+Regulation of Mitochondrial ATP Synthesis Visualized at the Single Cell Level

(2011) Masahiro Nakano et al.   ACS Chemical Biology

Trafficking Kinesin Protein (TRAK)-mediated Transport of Mitochondria in Axons of Hippocampal Neurons

(2011) Kieran Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Regulation of Surface Glucose Transporter-3

(2011) J. M. Ferreira et al.   JOURNAL OF NEUROSCIENCE

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

From the stochasticity of molecular processes to the variability of synaptic transmission

(2011) Claire Ribrault et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

(2011) Merina Varghese et al.   Translational Neuroscience

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

(2010) Victor S. Van Laar et al.   HUMAN MOLECULAR GENETICS

Expression of  -Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

(2010) X.-L. Zhao et al.   JOURNAL OF NEUROSCIENCE

The Micro-Architecture of Mitochondria at Active Zones: Electron Tomography Reveals Novel Anchoring Scaffolds and Cristae Structured for High-Rate Metabolism

(2010) G. A. Perkins et al.   JOURNAL OF NEUROSCIENCE

Evidence That Myosin Activity Opposes Microtubule-Based Axonal Transport of Mitochondria

(2010) D. Pathak et al.   JOURNAL OF NEUROSCIENCE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Human Myo19 Is a Novel Myosin that Associates with Mitochondria

(2009) Omar A. Quintero et al.   CURRENT BIOLOGY

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Bcl-xLincreases mitochondrial fission, fusion, and biomass in neurons

(2009) Sarah B. Berman et al.   JOURNAL OF CELL BIOLOGY

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

KIF5B Motor Adaptor Syntabulin Maintains Synaptic Transmission in Sympathetic Neurons

(2009) H. Ma et al.   JOURNAL OF NEUROSCIENCE

Drosophila Miro Is Required for Both Anterograde and Retrograde Axonal Mitochondrial Transport

(2009) G. J. Russo et al.   JOURNAL OF NEUROSCIENCE

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

A genetically encoded fluorescent reporter of ATP:ADP ratio

(2009) Jim Berg et al.   NATURE METHODS

The probability of neurotransmitter release: variability and feedback control at single synapses

(2009) Tiago Branco et al.   NATURE REVIEWS NEUROSCIENCE

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

(2009) Kanae Iijima-Ando et al.   PLoS One

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

(2008) Mandana Amiri et al.   Developmental Neurobiology

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

(2008) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

(2008) M. Saotome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA