Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level

Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity

(2021) Penny Gordon-Larsen et al.   Advances in Nutrition

Polyunsaturated fatty acids, specialized pro-resolving mediators, and targeting inflammation resolution in the age of precision nutrition

(2021) Abrar E. Al-Shaer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Proresolving lipid mediators and liver disease

(2021) Joan Clària et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila

(2021) Anandita Pal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Full body loss of the nuclear hormone receptor Nr4a3 results induces obesity and glucose intolerance.

(2020) Haokun Yang et al.   FASEB JOURNAL

Gender differences in diet-induced steatotic disease in Cyp2b-null mice

(2020) Melissa M. Heintz et al.   PLoS One

The Anti-inflammatory Mediator Resolvin E1 Protects Mice Against Lipopolysaccharide-Induced Heart Injury

(2020) Jishou Zhang et al.   Frontiers in Pharmacology

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

(2020) Anandita Pal et al.   FASEB JOURNAL

Plasma oxylipins respond in a linear dose-response manner with increased intake of EPA and DHA: results from a randomized controlled trial in healthy humans

(2019) Annika I Ostermann et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions—Brief Report

(2019) Emiel P.C. van der Vorst et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder

(2019) Abrar E. Al-Shaer et al.   PLoS Computational Biology

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation

(2019) Ana Beatriz DePaula-Silva et al.   Journal of Neuroinflammation

TPM2 as a potential predictive biomarker for atherosclerosis

(2019) Ling-Bing Meng et al.   Aging-US

Chemokines in homeostasis and diseases

(2018) Keqiang Chen et al.   Cellular & Molecular Immunology

ERV1/ChemR23 Signaling Protects from Atherosclerosis by Modifying oxLDL Uptake and Phagocytosis in Macrophages

(2018) Andres Laguna-Fernandez et al.   CIRCULATION

FGF21 gene therapy as treatment for obesity and insulin resistance

(2018) Veronica Jimenez et al.   EMBO Molecular Medicine

Identification of potential crucial genes and construction of microRNA-mRNA negative regulatory networks in osteosarcoma

(2018) Yue Pan et al.   HEREDITAS

Function of Pro-Resolving Lipid Mediator Resolvin E1 in Type 2 Diabetes

(2018) Corneliu Sima et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Frontline Science: A reduction in DHA-derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody

(2018) Miranda J. Crouch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

(2017) Rasagna Kosaraju et al.   JOURNAL OF IMMUNOLOGY

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

(2017) Justin T. English et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Identification, signaling, and functions of LTB 4 receptors

(2017) Kazuko Saeki et al.   SEMINARS IN IMMUNOLOGY

The role of the LTB 4 -BLT1 axis in chemotactic gradient sensing and directed leukocyte migration

(2017) Bhagawat C. Subramanian et al.   SEMINARS IN IMMUNOLOGY

Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals

(2017) Cristina López-Vicario et al.   Scientific Reports

The Imbalance of B-Lymphocyte Subsets in Subjects with Different Glucose Tolerance: Relationship with Metabolic Parameter and Disease Status

(2017) Chao Deng et al.   Journal of Diabetes Research

ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance

(2017) Corneliu Sima et al.   Scientific Reports

The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway

(2016) Yang Sun et al.   DIABETES

The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice

(2016) Ying Cui et al.   DIABETOLOGIA

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

(2016) Krishnaraj S. Rathod et al.   JOURNAL OF CLINICAL INVESTIGATION

CIS is a potent checkpoint in NK cell–mediated tumor immunity

(2016) Rebecca B Delconte et al.   NATURE IMMUNOLOGY

Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic–pituitary–gonadal (HPG) axis and peripheral organs (fat, pancreas and liver) in male rats

(2016) M. Dudek et al.   NEUROPEPTIDES

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation

(2016) No-Joon Song et al.   PLoS One

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Cish actively silences TCR signaling in CD8 + T cells to maintain tumor tolerance

(2015) Douglas C. Palmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages

(2015) Magdalena Herová et al.   JOURNAL OF IMMUNOLOGY

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

(2015) Pingping Li et al.   NATURE MEDICINE

Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues

(2015) Rodrigo Valenzuela et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

(2014) Wissal El-Assaad et al.   DIABETOLOGIA

Impact of Resolvin E1 on Murine Neutrophil Phagocytosis in Type 2 Diabetes

(2014) Bruno S. Herrera et al.   INFECTION AND IMMUNITY

Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function

(2014) Craig S Nunemaker et al.   JOURNAL OF ENDOCRINOLOGY

SMAD Transcription Factor, Sma-9, Attunes TGF-β Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans

(2014) Rizwanul Haque et al.   MOLECULAR NEUROBIOLOGY

The Interferon-Induced Gene Ifi27l2a is Active in Lung Macrophages and Lymphocytes After Influenza A Infection but Deletion of Ifi27l2a in Mice Does Not Increase Susceptibility to Infection

(2014) Mohamed A. Tantawy et al.   PLoS One

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells

(2014) Nathan C. Boles et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

ChemR23 knockout mice display mild obesity but no deficit in adipocyte differentiation

(2013) Laurie Rouger et al.   JOURNAL OF ENDOCRINOLOGY

Fatty Liver Is Associated with Transcriptional Downregulation of Stearoyl-CoA Desaturase and Impaired Protein Dimerization

(2013) Tomas Fernández Gianotti et al.   PLoS One

Integrating Genetic Association, Genetics of Gene Expression, and Single Nucleotide Polymorphism Set Analysis to Identify Susceptibility Loci for Type 2 Diabetes Mellitus

(2012) D. M. Greenawalt et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

(2012) Y. Tang et al.   DIABETES

Detecting differential usage of exons from RNA-seq data

(2012) S. Anders et al.   GENOME RESEARCH

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance

(2012) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GWASdb: a database for human genetic variants identified by genome-wide association studies

(2011) Mulin Jun Li et al.   NUCLEIC ACIDS RESEARCH

Chemerin/ChemR23 pathway: a system beyond chemokines

(2011) Florenzo Iannone et al.   ARTHRITIS RESEARCH & THERAPY

The Novel Activated Microglia/Macrophage WAP Domain Protein, AMWAP, Acts as a Counter-Regulator of Proinflammatory Response

(2010) M. Karlstetter et al.   JOURNAL OF IMMUNOLOGY

Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease

(2010) Irina A. Kirpich et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL