Drosophilacancer models

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Identification of Novel Ras-Cooperating Oncogenes inDrosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

(2011) Anthony M. Brumby et al.   GENETICS

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy

(2010) Francesca Froldi et al.   BMC BIOLOGY

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

(2010) Gongping Sun et al.   DEVELOPMENTAL BIOLOGY

Oncogenic Ras Diverts a Host TNF Tumor Suppressor Activity into Tumor Promoter

(2010) Julia B. Cordero et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer

(2010) Sonia Mulero-Navarro et al.   Epigenetics

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Interaction between Ras V12 and scribbled clones induces tumour growth and invasion

(2010) Ming Wu et al.   NATURE

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

(2010) A. Janic et al.   SCIENCE

Drosophila as a Novel Therapeutic Discovery Tool for Thyroid Cancer

(2010) Tirtha Das et al.   THYROID

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

(2009) Tatsushi Igaki et al.   DEVELOPMENTAL CELL

Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells

(2009) M. Kajita et al.   JOURNAL OF CELL SCIENCE

A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants

(2009) Sean P. Curran et al.   NATURE

Characterization of the interface between normal and transformed epithelial cells

(2009) Catherine Hogan et al.   NATURE CELL BIOLOGY

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

(2009) Anne-Kathrin Classen et al.   NATURE GENETICS

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

(2009) Anne-Marie Martinez et al.   NATURE GENETICS

Medullary Thyroid Cancer: Molecular Biology and Novel Molecular Therapies

(2009) Mehtap Cakir et al.   NEUROENDOCRINOLOGY

Giant Intracranial Medullary Thyroid Carcinoma Metastasis Presenting as Apoplexy

(2009) Matthew Bobinski et al.   SKULL BASE-AN INTERDISCIPLINARY APPROACH

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

The Quest for the 1p36 Tumor Suppressor

(2008) A. Bagchi et al.   CANCER RESEARCH

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

(2008) Lixing Zhan et al.   CELL

From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage

(2008) S. Giordano et al.   CURRENT MEDICINAL CHEMISTRY

Management of Medullary Thyroid Carcinoma

(2008) Camilo Jiménez et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

CHD5 , a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas

(2008) Tomoyuki Fujita et al.   JNCI-Journal of the National Cancer Institute

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

(2008) Shuang Chang et al.   Nature Chemical Biology

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

(2008) P O Humbert et al.   ONCOGENE

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

(2008) L E Dow et al.   ONCOGENE

TNF and cancer: the two sides of the coin

(2007) Simone Mocellin   Frontiers in Bioscience-Landmark