Self-assembled nanomaterials for ferroptosis-based cancer theranostics

Fe(II)-hydrazide coordinated all-active metal organic framework for photothermally enhanced tumor penetration and ferroptosis-apoptosis synergistic therapy

(2022) Weijun Xu et al.   CHEMICAL ENGINEERING JOURNAL

Metabolic Intervention Nanoparticles for Triple‐Negative Breast Cancer Therapy via Overcoming FSP1‐Mediated Ferroptosis Resistance

(2022) Jie Yang et al.   Advanced Healthcare Materials

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

(2022) Renye Yue et al.   Chem

Inducible endothelial leakiness in nanotherapeutic applications

(2022) Nengyi Ni et al.   BIOMATERIALS

FeC2O4/g-C3N4 self-assemble nanorods regulate stimuli-responsive ferroptosis via photo-fenton mechanism

(2022) Ziqi Cao et al.   APPLIED SURFACE SCIENCE

Liquid exfoliation of ultrasmall zirconium carbide nanodots as a noninflammatory photothermal agent in the treatment of glioma

(2022) Dongdong Liu et al.   BIOMATERIALS

Engineered anti-cancer nanomedicine for synergistic ferroptosis-immunotherapy

(2022) Xinyu Zhang et al.   CHEMICAL ENGINEERING JOURNAL

System Xc−: a key regulatory target of ferroptosis in cancer

(2021) Man-ru Liu et al.   INVESTIGATIONAL NEW DRUGS

Self-assembled nano-activator constructed ferroptosis-immunotherapy through hijacking endogenous iron to intracellular positive feedback loop

(2021) Hui Xiong et al.   JOURNAL OF CONTROLLED RELEASE

The role of amino acid metabolism in signaling and metabolic adaptation to stress induced energy deficiency in plants

(2021) Björn Heinemann et al.   JOURNAL OF EXPERIMENTAL BOTANY

Acidity‐Activatable Dynamic Nanoparticles Boosting Ferroptotic Cell Death for Immunotherapy of Cancer

(2021) Rundi Song et al.   ADVANCED MATERIALS

The potential application of nanomaterials for ferroptosis-based cancer therapy

(2021) Yingze Li et al.   Biomedical Materials

A glutathione-responsive polyphenol - Constructed nanodevice for double roles in apoptosis and ferroptosis

(2021) Hao Chen et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Effect of Malt-PEG-Abz@RSL3 micelles on HepG2 cells based on NADPH depletion and GPX4 inhibition in ferroptosis

(2021) Wenhua Li et al.   JOURNAL OF DRUG TARGETING

The Sustainability of Energy Conversion Inhibition for Tumor Ferroptosis Therapy and Chemotherapy

(2021) Wei Jiang et al.   Small

Self‐Cycling Free Radical Generator from LDH‐Based Nanohybrids for Ferroptosis‐Enhanced Chemodynamic Therapy

(2021) Xueting Yang et al.   Advanced Healthcare Materials

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

(2021) Xiaoyan Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Fe(III)‐Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis

(2021) Wenjie Feng et al.   Advanced Healthcare Materials

A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy

(2021) Xueming Xu et al.   Biomaterials Science

Biomimetic Nanomaterials Triggered Ferroptosis for Cancer Theranostics

(2021) Xinyu Zhang et al.   Frontiers in Chemistry

Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance

(2021) Haibao Peng et al.   Bioactive Materials

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

(2020) Yanwei Su et al.   CANCER LETTERS

The Antioxidant Role of Non-mitochondrial CoQ10: Mystery Solved!

(2020) Massimo M. Santoro   Cell Metabolism

Ferroptosis-driven nanotherapeutics for cancer treatment

(2020) Xinzhu Shan et al.   JOURNAL OF CONTROLLED RELEASE

Polypeptide-Based Theranostics with Tumor-Microenvironment-Activatable Cascade Reaction for Chemo-ferroptosis Combination Therapy

(2020) Zhiliang Gao et al.   ACS Applied Materials & Interfaces

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

(2020) Tian Xu et al.   ACS Nano

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Nanoparticles (NPs)‐Meditated LncRNA AFAP1‐AS1 Silencing to Block Wnt/ β ‐Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy

(2020) Zhuofei Bi et al.   Advanced Science

Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases

(2020) Marcus Conrad et al.   TRENDS IN MOLECULAR MEDICINE

Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers

(2020) Minlin Jiang et al.   Translational Lung Cancer Research

A redox-triggered C-centered free radicals nanogenerator for self-enhanced magnetic resonance imaging and chemodynamic therapy

(2020) Jian Chen et al.   BIOMATERIALS

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

A Hypoxia‐Responsive Albumin‐Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

(2019) Guangbao Yang et al.   ADVANCED MATERIALS

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

(2019) Dangge Wang et al.   Science Immunology

Intracellular cascade activated nanosystem for improving ER+ breast cancer therapy through attacking GSH-mediated metabolic vulnerability

(2019) Hui Xiong et al.   JOURNAL OF CONTROLLED RELEASE

Ferroptosis and kidney diseases

(2019) Shumei Tang et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

(2019) Fei Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

(2019) Xuan Meng et al.   NANO LETTERS

A powerful cell-protection system prevents cell death by ferroptosis

(2019) Brent R. Stockwell   NATURE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Light-Enhanced Hypoxia-Response of Conjugated Polymer Nanocarrier for Successive Synergistic Photodynamic and Chemo-Therapy

(2018) Xiaolong Zhang et al.   ACS Applied Materials & Interfaces

Emerging Strategies of Cancer Therapy Based on Ferroptosis

(2018) Zheyu Shen et al.   ADVANCED MATERIALS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

Supramolecular photosensitizers rejuvenate photodynamic therapy

(2018) Xingshu Li et al.   CHEMICAL SOCIETY REVIEWS

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Recent Insights on Hydrogen Atom Transfer in the Inhibition of Hydrocarbon Autoxidation

(2018) Jia-Fei Poon et al.   ACCOUNTS OF CHEMICAL RESEARCH

BECN1 is a new driver of ferroptosis

(2018) Rui Kang et al.   Autophagy

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy

(2016) Chao Liang et al.   CHEMICAL SOCIETY REVIEWS

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Antimicrobial activity of metals: mechanisms, molecular targets and applications

(2013) Joseph A. Lemire et al.   NATURE REVIEWS MICROBIOLOGY

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis

(2012) L. Ouyang et al.   CELL PROLIFERATION

Directed Self-Assembly of Nanoparticles

(2010) Marek Grzelczak et al.   ACS Nano

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles

(2008) Xuezhong He et al.   PHARMACEUTICAL RESEARCH