Fe(III)‐Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis

NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

(2021) Chencheng Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

(2021) Yuxin Guo et al.   ADVANCED MATERIALS

Low-intensity focused ultrasound-augmented Cascade chemodynamic therapy via boosting ROS generation

(2021) Liming Deng et al.   BIOMATERIALS

Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy

(2021) Jinbo Li et al.   JOURNAL OF CONTROLLED RELEASE

Functionalized Tumor‐Targeting Nanosheets Exhibiting Fe(II) Overloading and GSH Consumption for Ferroptosis Activation in Liver Tumor

(2021) Ke Li et al.   Small

Self‐Cycling Free Radical Generator from LDH‐Based Nanohybrids for Ferroptosis‐Enhanced Chemodynamic Therapy

(2021) Xueting Yang et al.   Advanced Healthcare Materials

An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation

(2021) Jingjing Xie et al.   CCS Chemistry

Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification

(2020) Jingjing Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

(2020) Yanjuan Sang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

(2020) Yu-Jing He et al.   BIOMATERIALS

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells

(2020) Chen-Cheng Xue et al.   Science Advances

A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

(2020) Yuan Ding et al.   Advanced Science

Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy

(2020) Lisen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Melatonin sensitises shikonin-induced cancer cell death mediated by oxidative stress via inhibition of the SIRT3/SOD2-AKT pathway

(2020) Mengling Li et al.   Redox Biology

Polyphenol-cisplatin complexation forming core-shell nanoparticles with improved tumor accumulation and dual-responsive drug release for enhanced cancer chemotherapy

(2020) Jiajia Xiang et al.   JOURNAL OF CONTROLLED RELEASE

Peptide-based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improve Chemotherapy Resistance

(2019) Yaoxin Lin et al.   NANO LETTERS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Shikonin derivatives for cancer prevention and therapy

(2019) Joelle C. Boulos et al.   CANCER LETTERS

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

(2019) Hairui Wang et al.   NANO LETTERS

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles

(2019) Jing Yu et al.   ACS Nano

Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities

(2019) Gang-Gang Yang et al.   BIOMATERIALS

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

MiR-7-5p is a key factor that controls radioresistance via intracellular Fe2+ content in clinically relevant radioresistant cells

(2019) Kazuo Tomita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

(2019) Zhigang Ren et al.   ADVANCED MATERIALS

Novel Metal Polyphenol Framework for MR Imaging-Guided Photothermal Therapy

(2018) Gaozheng Zhao et al.   ACS Applied Materials & Interfaces

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

(2018) Yang Liu et al.   ACS Nano

Metal Ion/Tannic Acid Assembly as a Versatile Photothermal Platform in Engineering Multimodal Nanotheranostics for Advanced Applications

(2018) Tao Liu et al.   ACS Nano

Core-Satellite Mesoporous Silica-Gold Nanotheranostics for Biological Stimuli Triggered Multimodal Cancer Therapy

(2018) Ronghua Jin et al.   ADVANCED FUNCTIONAL MATERIALS

Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles

(2018) Yunlu Dai et al.   ADVANCED MATERIALS

Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

(2018) Han Lin et al.   CHEMICAL SOCIETY REVIEWS

Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas

(2018) Zhilu Yang et al.   CHEMISTRY OF MATERIALS

Synthesis and biological evaluation of sulfur-containing shikonin oxime derivatives as potential antineoplastic agents

(2018) Guang Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and characterization of α -lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors

(2018) Hong-Yan Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lactoferrin functionalized PEG-PLGA nanoparticles of shikonin for brain targeting therapy of glioma

(2018) Hanmei Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis

(2018) Suoyuan Li et al.   Theranostics

Multifunctional Theranostic Nanoparticles Derived from Fruit-Extracted Anthocyanins with Dynamic Disassembly and Elimination Abilities

(2018) Caina Xu et al.   ACS Nano

Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction

(2018) Zhongmin Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

(2018) Shuaifei Wang et al.   ACS Nano

Ferrous-Supply-Regeneration Nanoengineering for Cancer-Cell-Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy

(2018) Tao Liu et al.   ACS Nano

Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin

(2018) Yongxin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

An Adenosine Triphosphate-Responsive Autocatalytic Fenton Nanoparticle for Tumor Ablation with Self-Supplied H2O2 and Acceleration of Fe(III)/Fe(II) Conversion

(2018) Lu Zhang et al.   NANO LETTERS

Successful in vivo hyperthermal therapy toward breast cancer by Chinese medicine shikonin-loaded thermosensitive micelle

(2017) Yonghua Su et al.   International Journal of Nanomedicine

Fluorinated PEG-Polypeptide Polyplex Micelles Have Good Serum-Resistance and Low Cytotoxicity for Gene Delivery

(2017) Ting Wu et al.   MACROMOLECULAR BIOSCIENCE

Enhanced Phototherapy by Nanoparticle-Enzyme via Generation and Photolysis of Hydrogen Peroxide

(2017) Kaiwen Chang et al.   NANO LETTERS

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Versatile Types of MRI-Visible Cationic Nanoparticles Involving Pullulan Polysaccharides for Multifunctional Gene Carriers

(2016) Yajun Huang et al.   ACS Applied Materials & Interfaces

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

(2016) Nasha Qiu et al.   ADVANCED MATERIALS

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications

(2015) Fuyao Liu et al.   Nature Communications

Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer

(2015) Ravi Thakur et al.   Scientific Reports

Engineering Multifunctional Capsules through the Assembly of Metal-Phenolic Networks

(2014) Junling Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-delivery of doxorubicin and paclitaxel by PEG-polypeptide nanovehicle for the treatment of non-small cell lung cancer

(2014) Shixian Lv et al.   BIOMATERIALS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways

(2014) Yongqiang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Viral Mimicking Ternary Polyplexes: A Reduction-Controlled Hierarchical Unpacking Vector for Gene Delivery

(2013) Yiyan He et al.   ADVANCED MATERIALS

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

One-Step Assembly of Coordination Complexes for Versatile Film and Particle Engineering

(2013) H. Ejima et al.   SCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells

(2008) Xin Mao et al.   CELL RESEARCH