Article
Medicine, Research & Experimental
Xiaojun Sun, Guotao Guan, Yunpeng Dai, Ping Zhao, Liying Liu, Qi Wang, Xiuli Li
Summary: The study investigated the role of miR-155-5p in childhood acute lymphoblastic leukemia, revealing that miR-155-5p targets CBL and inhibits its expression, leading to reduced degradation of IRF4 and increased expression of CDK6. These findings suggest potential therapeutic strategies for cALL in the future.
LABORATORY INVESTIGATION
(2022)
Article
Oncology
Bou-Yue Peng, Abhinay Kumar Singh, Chun-Hao Chan, Yue-Hua Deng, Pin-Ying Li, Chun-Wei Su, Chia-Yu Wu, Win-Ping Deng
Summary: In this study, the researchers found that AGA has the potential to inhibit colon cancer by inhibiting proliferation, migration, and cell cycle kinase through upregulating p21 protein expression and promoting apoptotic protein in a p53-dependent and independent manner.
Article
Oncology
Li Li, Xinyi Tao, Yandong Li, Yong Gao, Qinchuan Li
Summary: This study revealed a tumor-suppressive role of CDC37L1 in gastric cancer, which inhibits cancer progression by regulating cell proliferation and migration, potentially through modulation of CDK6 protein expression.
Article
Chemistry, Multidisciplinary
Tian Xia, Xin-Yuan Dai, Ming-Yi Sang, Xu Zhang, Feng Xu, Jing Wu, Liang Shi, Ji-Fu Wei, Qiang Ding
Summary: IGF2BP2 is highly expressed in TNBC and promotes TNBC proliferation by recruiting EIF4A1 to facilitate the translation output of CDK6. Downregulation of IGF2BP2 increases TNBC sensitivity to CDK4/6 inhibitors, providing a new strategy for TNBC treatment.
Article
Oncology
Jinglin Zhang, Bonan Chen, Yifei Wang, Xiaoli Liu, Huan Yan, Kit Yee Wong, Aden K. Y. Chan, Alvin H. K. Cheung, Chit Chow, Dazhi Xu, Shouyu Wang, Bing Huang, Li Liang, Huixing Ke, Chi Chun Wong, William K. K. Wu, Alfred S. L. Cheng, Jun Yu, Kwok Wai Lo, Ka Fai To, Wei Kang
Summary: This study reveals the oncogenic role of HOXB9 in gastric cancer and identifies CDK6 as its downstream effector. The E2F1-HOXB9/PBX2-CDK6 axis represents a novel mechanism driving gastric carcinogenesis and has prognostic and therapeutic implications.
JOURNAL OF PATHOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Peilin Zhong, Aihua Guo, Linhua Wang, Xiurong Lin, Mei Feng
Summary: This study aimed to investigate the effect of circRNA CDK6 (circCDK6) on the development and biological behavior of cervical cancer. The results showed that circCDK6 expression level significantly increased in various cervical cancer cells. MiR-449a was identified as a potential target of circCDK6, and silencing circCDK6 led to increased expression of miR-449a. CircCDK6 participated in tumorigenesis and cancer progression and potentially functioned as a tumor suppressor in cervical cell progression through the Epithelial-Mesenchymal Transition (EMT) process by regulating miR-449a.
Article
Immunology
Guoxin Zhang, Zhen Dong, Ryan C. Gimple, Arthur Wolin, Qiulian Wu, Zhixin Qiu, Lisa M. Wood, Jia Z. Shen, Li Jiang, Linjie Zhao, Deguan Lv, Briana C. Prager, Leo J. Y. Kim, Xiuxing Wang, Lingdi Zhang, Ryan L. Anderson, Jeffrey K. Moore, Shideng Bao, Thomas H. Keller, Grace Lin, Congbao Kang, Petra Hamerlik, Rui Zhao, Heide L. Ford, Jeremy N. Rich
Summary: EYA2, preferentially expressed in GSCs, plays critical roles in their growth and survival by affecting mitotic spindle assembly and cell cycle progression. Inhibitors targeting EYA2 may offer potential therapeutic benefits for GSCs.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Arwa Aldaalis, Maria T. Bengoechea-Alonso, Johan Ericsson
Summary: The transcription factor SREBP1 positively regulates the expression of cyclin D1 by binding to an E-box in the cyclin D1 promoter. Inactivation of SREBP1 reduces cyclin D1 expression and attenuates Rb phosphorylation, while activation of SREBP1 increases cyclin D1 expression and enhances Rb phosphorylation. The regulation of cyclin D1 by SREBP1 coordinates cell proliferation with enhanced lipid synthesis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Magdalena Barreca, Chiara Zichittella, Riccardo Alessandro, Alice Conigliaro
Summary: Hypoxia, a key characteristic of the tumor microenvironment, is crucial for cancer progression and therapeutic response. The hypoxia-inducible factors (HIFs) play a master regulatory role in modulating hypoxic gene expression and signaling pathways, ultimately changing the cell phenotype to be more aggressive. Non-coding RNAs (ncRNAs) have been identified as important molecular mediators in hypoxic responses, regulating gene expression at various levels and contributing to tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Simone Di Franco, Paola Bianca, Davide Stefano Sardina, Alice Turdo, Miriam Gaggianesi, Veronica Veschi, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Irene Pillitteri, Sander van Hooff, Federica Martorana, Gianmarco Motta, Eliana Gulotta, Vincenzo Luca Lentini, Emanuele Martorana, Micol Eleonora Fiori, Salvatore Vieni, Maria Rita Bongiorno, Giorgio Giannone, Dario Giuffrida, Lorenzo Memeo, Lorenzo Colarossi, Marzia Mare, Paolo Vigneri, Matilde Todaro, Ruggero De Maria, Jan Paul Medema, Giorgio Stassi
Summary: Obesity is identified as a major risk factor for cancer related deaths. Visceral adipose-derived factors activate STAT3, inhibiting miR-200a and enhancing ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Daniella A. Gomes, Anna M. Joubert, Michelle H. Visagie
Summary: The study found that papaverine (PPV) exhibits dose- and time-dependent antiproliferative activity on MDA-MB-231, A549, and DU145 cell lines, while also increasing cellular protrusions and oxidative stress. Exposure to PPV resulted in alterations in cell cycle progression, with more cells entering the sub-G(1) phase and endoreduplication.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Hongbin Su, Mengdi Qin, Qiang Liu, Bo Jin, Xianjun Shi, Zheng Xiang
Summary: UBD, a member of the UBL family, is highly expressed in CRC and plays a regulatory role in promoting CRC cell proliferation. Overexpression of UBD in CRC tissues is associated with tumor size and TNM stage of patients. Mechanistically, UBD interacts with p53, leading to its degradation and subsequent effects on cell cycle regulators, ultimately promoting CRC progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Haonan Zhang, Chengcheng He, Xuxue Guo, Yuxin Fang, Qiuhua Lai, Xinke Wang, Xingzhu Pan, Haolin Li, Kaiwen Qin, Aimin Li, Side Liu, Qingyuan Li
Summary: DDX39B has been found to play a pivotal role in the proliferation of human colorectal cancer cells by promoting the cell cycle transition and upregulating the expression of CDK6/CCND1, suggesting it could be a potential therapeutic target.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Multidisciplinary
Marc Zimmer
CHEMICAL & ENGINEERING NEWS
(2008)
Article
Chemistry, Physical
Nathan P. Lemay, Alicia L. Morgan, Elizabeth J. Archer, Luisa A. Dickson, Colleen M. Megley, Marc Zimmer
Article
Chemistry, Physical
Binsen Li, Ramza Shahid, Paola Peshkepija, Marc Zimmer
Article
Chemistry, Physical
Matthew H. Zimmer, Binsen Li, Ramza Shahid, Paola Peshkepija, Marc Zimmer
Review
Chemistry, Multidisciplinary
Marc Zimmer
CHEMICAL SOCIETY REVIEWS
(2009)
Review
Chemistry, Inorganic & Nuclear
Marc Zimmer
COORDINATION CHEMISTRY REVIEWS
(2009)
Article
Chemistry, Physical
Colleen M. Megley, Luisa A. Dickson, Scott L. Maddalo, Gabriel J. Chandler, Marc Zimmer
JOURNAL OF PHYSICAL CHEMISTRY B
(2009)
Article
Chemistry, Physical
Alex A. Samma, Chelsea K. Johnson, Shuang Song, Samuel Alvarez, Marc Zimmer
JOURNAL OF PHYSICAL CHEMISTRY B
(2010)
Article
Biochemistry & Molecular Biology
Wayne J. -H. Ong, Samuel Alvarez, Ivan E. Leroux, Ramza S. Shahid, Alex A. Samma, Paola Peshkepija, Alicia L. Morgan, Shawn Mulcahy, Marc Zimmer
MOLECULAR BIOSYSTEMS
(2011)
Article
Biochemistry & Molecular Biology
Justin Nwafor, Christian Salguero, Franceine Welcome, Sercan Durmus, Rachel N. Glasser, Marc Zimmer, Tanya L. Schneider
Summary: Studies have shown that the conserved glycines Gly31, 33, and 35 are essential for maintaining the integrity of the fluorescent protein structure, while molecular dynamics simulations indicate that mutating these glycines to alanine does not reduce chromophore formation.
Article
Biochemistry & Molecular Biology
Bruce R. Branchini, Danielle M. Ablamsky, Julie M. Rosenman, Lerna Uzasci, Tara L. Southworth, Marc Zimmer
Article
Chemistry, Inorganic & Nuclear
C Mbofana, M Zimmer
INORGANIC CHEMISTRY
(2006)
Article
Biochemistry & Molecular Biology
SL Maddalo, M Zimmer
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2006)
Article
Biochemistry & Molecular Biology
BR Branchini, TL Southworth, MH Murtiashaw, SR Wilkinson, NF Khattak, JC Rosenberg, M Zimmer