Journal
CELL CYCLE
Volume 9, Issue 8, Pages 1551-1561Publisher
LANDES BIOSCIENCE
DOI: 10.4161/cc.9.8.11195
Keywords
cyclin-dependent kinases; cell cycle; transcription; crystallographic structures; protein-protein interactions
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Funding
- Federation of European Biochemical Societies
- Fondazione Cassa di Risparmio de Padova e Rovigo
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Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. They are regulated by their cyclin partners and by a variety of additional protein effectors (inhibitors, kinases, phosphatases). Each CDK serves its function by means of specific protein recognition properties. These are also responsible for the differential regulation of CDKs/Cyclin couples involved in processes as different as cell cycle and transcription. The structural features determining general and specific properties for CDKs/Cyclin complexes are analyzed. They reside in an overall conserved architecture with divergent spots used by the complexes to present themselves to specific substrates or other protein effectors.
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