Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunity

Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

(2022) Tarin M. Bigley et al.   Molecular Neurodegeneration

Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function

(2022) Md Masud Alam et al.   Cell Reports

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

(2022) Kazuhisa Ishida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes

(2022) Teresa Gómez-Isla et al.   Nature Reviews Neurology

Pathogens infecting the central nervous system

(2022) Yohann Le Govic et al.   PLoS Pathogens

Potential Involvement of Varicella Zoster Virus in Alzheimer’s Disease via Reactivation of Quiescent Herpes Simplex Virus Type 1

(2022) Dana M. Cairns et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of microbial infection in the pathogenesis of Alzheimer’s disease and the opportunity for protection by anti-microbial peptides

(2021) Feijie Li et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases

(2021) Christine Römer   Frontiers in Neuroscience

Brain Somatic Mutation in Aging and Alzheimer's Disease

(2021) Michael B. Miller et al.   Annual Review of Genomics and Human Genetics

Much ado about nothing? Off-target amplification can lead to false-positive bacterial brain microbiome detection in healthy and Parkinson’s disease individuals

(2021) Janis R. Bedarf et al.   Microbiome

Alzheimer’s disease-associated β-amyloid does not protect against herpes simplex virus 1 infection in the mouse brain

(2021) Olga Bocharova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of retrotransposable elements in ageing and age-associated diseases

(2021) Vera Gorbunova et al.   NATURE

Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer's disease

(2020) Morgane Linard et al.   Alzheimers & Dementia

What Are the Molecular Mechanisms by Which Functional Bacterial Amyloids Influence Amyloid Beta Deposition and Neuroinflammation in Neurodegenerative Disorders?

(2020) Robert P. Friedland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial

(2020) D P Devanand et al.   BMJ Open

Awakening the dark side: retrotransposon activation in neurodegenerative disorders

(2020) Elizabeth Ochoa Thomas et al.   CURRENT OPINION IN NEUROBIOLOGY

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

(2020) Ethan R. Roy et al.   JOURNAL OF CLINICAL INVESTIGATION

Mosaic Somatic Gene Recombination as a Potentially Unifying Hypothesis for Alzheimer’s Disease

(2020) Gwendolyn E. Kaeser et al.   Frontiers in Genetics

A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease

(2020) Dana M. Cairns et al.   Science Advances

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study

(2020) Seongman Bae et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The Use of Antimicrobial and Antiviral Drugs in Alzheimer’s Disease

(2020) Umar H. Iqbal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC

(2020) Ibrahim Javed et al.   Advanced Science

DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

(2020) Nidheesh Thadathil et al.   MOLECULAR NEUROBIOLOGY

Reply to: APP gene copy number changes reflect exogenous contamination

(2020) Ming-Hsiang Lee et al.   NATURE

APP gene copy number changes reflect exogenous contamination

(2020) Junho Kim et al.   NATURE

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

(2020) Ji-Yeun Hur et al.   NATURE

Somatic mutations in neurodegeneration: An update

(2020) Christos Proukakis   NEUROBIOLOGY OF DISEASE

KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer’s Disease: Implication for the Role of Herpesvirus Infections

(2019) Roberta Rizzo et al.   JOURNAL OF ALZHEIMERS DISEASE

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice

(2019) Giovanna De Chiara et al.   PLoS Pathogens

Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies

(2019) Masomeh Bayani et al.   ACTA TROPICA

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Emerging Perspectives on DNA double-strand breaks in Neurodegenerative Diseases

(2019) Ling-Shuang Zhu et al.   Current Neuropharmacology

Neuroinvasion of Toxocara canis- and T. cati-larvae mediates dynamic changes in brain cytokine and chemokine profile

(2019) Patrick Waindok et al.   Journal of Neuroinflammation

Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model

(2019) Andrea Springer et al.   PARASITOLOGY RESEARCH

Brain somatic mutations observed in Alzheimer’s disease associated with aging and dysregulation of tau phosphorylation

(2019) Jun Sung Park et al.   Nature Communications

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study

(2019) Yanina Ivashko-Pachima et al.   MOLECULAR PSYCHIATRY

Is Toxoplasma gondii a potential risk factor for Alzheimer's disease? A systematic review and meta-analysis

(2019) Tooran Nayeri Chegeni et al.   MICROBIAL PATHOGENESIS

Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

(2019) Diego Perez-Rodriguez et al.   Acta Neuropathologica Communications

Genetics of Alzheimer’s disease: where we are, and where we are going

(2019) Céline Bellenguez et al.   CURRENT OPINION IN NEUROBIOLOGY

Viral Hypothesis and Antiviral Treatment in Alzheimer’s Disease

(2018) D. P. Devanand   Current Neurology and Neuroscience Reports

Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer’s Disease Development

(2018) Hugo Lövheim et al.   JOURNAL OF ALZHEIMERS DISEASE

Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice

(2018) Luisa Torres et al.   Journal of Neuroinflammation

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

Infection of Fungi and Bacteria in Brain Tissue From Elderly Persons and Patients With Alzheimer’s Disease

(2018) Ruth Alonso et al.   Frontiers in Aging Neuroscience

Helicobacter pylori Filtrate Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Glycogen Synthase Kinase-3β

(2018) Xiu-Lian Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Fungal Infection in Patients with Alzheimer's Disease

(2018) Ruth Alonso et al.   JOURNAL OF ALZHEIMERS DISEASE

Direct Visualization of Fungal Infection in Brains from Patients with Alzheimer's Disease

(2018) Diana Pisa et al.   JOURNAL OF ALZHEIMERS DISEASE

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

The lack of association between herpes simplex virus 1 or Toxoplasma gondii infection and cognitive decline in the general population: An 11-year follow-up study

(2018) M. Torniainen-Holm et al.   BRAIN BEHAVIOR AND IMMUNITY

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

Olfactory and other sensory impairments in Alzheimer disease

(2018) Claire Murphy   Nature Reviews Neurology

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

(2018) Yifan Wu et al.   Nature Communications

Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease

(2018) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia

(2018) Brian J. Balin et al.   Frontiers in Aging Neuroscience

Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing

(2017) Ruth Alonso et al.   JOURNAL OF ALZHEIMERS DISEASE

Is Periodontal Disease Associated with Alzheimer's Disease? A Systematic Review with Meta-Analysis

(2017) Yago Leira et al.   NEUROEPIDEMIOLOGY

Enhanced expressions of neurodegeneration-associated factors, UPS impairment, and excess Aβ accumulation in the hippocampus of mice with persistent cerebral toxocariasis

(2017) Chia-Mei Chou et al.   Parasites & Vectors

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis

(2017) Elisabeth Janecek et al.   PLoS Neglected Tropical Diseases

Herpes Simplex Virus Type 1 in Alzheimer's Disease: The Enemy Within

(2017) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuronal Cytoskeletal Dynamic Modification and Neurodegeneration Induced by Infection with Herpes Simplex Virus Type 1

(2017) Ángara Zambrano et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease-Specific Tau Phosphorylation is Induced by Herpes Simplex Virus Type 1

(2017) Matthew A. Wozniak et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice

(2017) Yicong Liu et al.   Scientific Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Seroprevalence and Serointensity of Latent Toxoplasma gondii in a Sample of Elderly Adults With and Without Alzheimer Disease

(2016) Cynthia E. Perry et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Alzheimer’s Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-β with Regard to Potential Treatment and Prevention

(2016) Herbert B. Allen   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Toxoplasmosis and Alzheimer: can Toxoplasma gondii really be introduced as a risk factor in etiology of Alzheimer?

(2016) Mahmoud Mahami-Oskouei et al.   PARASITOLOGY RESEARCH

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

(2016) Luisa Möhle et al.   Acta Neuropathologica Communications

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

(2016) Philipp Spitzer et al.   Scientific Reports

Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?

(2015) Chia-Kwung Fan et al.   CLINICAL MICROBIOLOGY REVIEWS

Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes

(2015) Elisabeth Janecek et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Anti-HSV1 activity of brown algal polysaccharides and possible relevance to the treatment of Alzheimer's disease

(2015) Matthew Wozniak et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Neurotoxocarosis alters myelin protein gene transcription and expression

(2015) Lea Heuer et al.   PARASITOLOGY RESEARCH

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

(2015) Roberto Piacentini et al.   Scientific Reports

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

(2015) Diane M Bushman et al.   eLife

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies

(2015) Olga G. James et al.   Frontiers in Neurology

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

(2015) Diana Pisa et al.   Scientific Reports

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

(2014) M. Carreiras et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacotherapy of Alzheimer’s disease: current and future trends

(2014) Werner J Geldenhuys et al.   Expert Review of Neurotherapeutics

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

(2014) Christopher S. Little et al.   Frontiers in Aging Neuroscience

The helicase-primase inhibitor BAY 57–1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1

(2013) M.A. Wozniak et al.   ANTIVIRAL RESEARCH

Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

(2013) Nell S. Lurain et al.   JOURNAL OF INFECTIOUS DISEASES

Intravenous immunoglobulin reduces beta amyloid and abnormal tau formation caused by herpes simplex virus type 1

(2013) Matthew A. Wozniak et al.   JOURNAL OF NEUROIMMUNOLOGY

Herpes virus in Alzheimer's disease: relation to progression of the disease

(2013) Ilaria Carbone et al.   NEUROBIOLOGY OF AGING

How and why Toxoplasma makes us crazy

(2013) Jaroslav Flegr   TRENDS IN PARASITOLOGY

The Neuroprotective Functions of Transforming Growth Factor Beta Proteins

(2012) Arpád Dobolyi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of latent Toxoplasma infection on human personality, physiology and morphology: pros and cons of the Toxoplasma-human model in studying the manipulation hypothesis

(2012) J. Flegr   JOURNAL OF EXPERIMENTAL BIOLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Toxoplasma gondii Infection in the Brain Inhibits Neuronal Degeneration and Learning and Memory Impairments in a Murine Model of Alzheimer's Disease

(2012) Bong-Kwang Jung et al.   PLoS One

Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity

(2012) J. Di Domizio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Could Toxoplasma gondii Have any Role in Alzheimer Disease?

(2010) Ozge Yilmaz Kusbeci et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain

(2010) Christine J Hammond et al.   BMC NEUROSCIENCE

Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

(2010) Jannis Kountouras et al.   Cognitive and Behavioral Neurology

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells

(2010) Walter J. Lukiw et al.   NEUROREPORT

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Mechanisms of immunosenescence

(2009) Calogero Caruso et al.   Immunity & Ageing

Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canisin mice

(2008) Chien-Wei Liao et al.   BMC INFECTIOUS DISEASES

Oskar Fischer and the study of dementia

(2008) M. Goedert   BRAIN

Initial characterization of Chlamydophila (Chlamydia) pneumoniae cultured from the late-onset Alzheimer brain

(2008) Ute Dreses-Werringloer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

(2008) Luc Letenneur et al.   PLoS One

Inflammation and Alzheimer's disease: Possible role of periodontal diseases

(2007) Angela R. Kamer et al.   Alzheimers & Dementia