APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining

Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK

(2022) Sofie Bergstrand et al.   Nature Communications

Structural analysis of the basal state of the Artemis:DNA-PKcs complex

(2022) Go Watanabe et al.   NUCLEIC ACIDS RESEARCH

The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened

(2022) Metztli Cisneros-Aguirre et al.   Nature Communications

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

(2022) Ivan Corbeski et al.   Science Advances

Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway

(2021) Benjamin M. Stinson et al.   Annual Review of Biochemistry

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Long noncoding RNA NIHCOLE promotes ligation efficiency of DNA double-strand breaks in hepatocellular carcinoma

(2021) Juan P. Unfried et al.   CANCER RESEARCH

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

(2021) Lan Liu et al.   MOLECULAR CELL

Chromatin mobility and relocation in DNA repair

(2021) Noa Lamm et al.   TRENDS IN CELL BIOLOGY

LRIK interacts with the Ku70–Ku80 heterodimer enhancing the efficiency of NHEJ repair

(2020) Dan Wang et al.   CELL DEATH AND DIFFERENTIATION

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of efficient double-strand break repair by a long non-coding RNA

(2020) Roopa Thapar et al.   NUCLEIC ACIDS RESEARCH

Life or Death after a Break: What Determines the Choice?

(2019) Lenno Krenning et al.   MOLECULAR CELL

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

Structural Insights into Yeast Telomerase Recruitment to Telomeres

(2018) Hongwen Chen et al.   CELL

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA repair factor APLF acts as a H2A-H2B histone chaperone through binding its DNA interaction surface

(2018) Ivan Corbeski et al.   NUCLEIC ACIDS RESEARCH

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A single XLF dimer bridges DNA ends during nonhomologous end joining

(2018) Thomas G. W. Graham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

(2018) Clement Nemoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining

(2017) Michael P. Conlin et al.   Cell Reports

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

(2016) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

(2016) Howard H. Y. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

Force and twist dependence of RepC nicking activity on torsionally-constrained DNA molecules

(2016) Cesar L. Pastrana et al.   NUCLEIC ACIDS RESEARCH

Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

(2015) Dylan A. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

Identification and Functional Characterization of a Ku-binding Motif in Aprataxin Polynucleotide Kinase/Phosphatase-like Factor (APLF)

(2013) Purnata Shirodkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining

(2013) V. Oksenych et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Putative binding modes of Ku70-SAP domain with double strand DNA: a molecular modeling study

(2011) Shaowen Hu et al.   JOURNAL OF MOLECULAR MODELING

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Efficient preparation of internally modified single-molecule constructs using nicking enzymes

(2010) N. Luzzietti et al.   NUCLEIC ACIDS RESEARCH

Visualizing helicases unwinding DNA at the single molecule level

(2010) Natali Fili et al.   NUCLEIC ACIDS RESEARCH

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4

(2009) P.-Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

(2008) Chloe J. Macrae et al.   DNA REPAIR

APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose) Signaling in Mammalian Cells

(2008) S. L. Rulten et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE