Chromatin mobility and relocation in DNA repair

High-content imaging-based pooled CRISPR screens in mammalian cells

(2021) Xiaowei Yan et al.   JOURNAL OF CELL BIOLOGY

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

(2021) Jia-Min Zhang et al.   MOLECULAR CELL

Rad52 SUMOylation functions as a molecular switch that determines a balance between the Rad51- and Rad59-dependent survivors

(2021) Ferose Charifi et al.   iScience

Mechanisms that drive telomere maintenance and recombination in human cancers

(2020) Alexander P Sobinoff et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation

(2020) Anqi Wang et al.   DEVELOPMENTAL CELL

Proximity dependent biotinylation: key enzymes and adaptation to proteomics approaches

(2020) Payman Samavarchi-Tehrani et al.   MOLECULAR & CELLULAR PROTEOMICS

The nuclear pore complex prevents sister chromatid recombination during replicative senescence

(2020) Paula Aguilera et al.   Nature Communications

Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres

(2020) Taylor K. Loe et al.   GENES & DEVELOPMENT

Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association

(2020) Jenna M. Whalen et al.   Cell Reports

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

(2020) Mian Wei et al.   Science Advances

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

(2020) Song My Hoang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex Chromatin Motions for DNA Repair

(2020) Judith Miné-Hattab et al.   Frontiers in Genetics

Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress

(2020) Noa Lamm et al.   NATURE CELL BIOLOGY

Actin on and around the Nucleus

(2020) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

The Nup84 complex coordinates the DNA damage response to warrant genome integrity

(2019) Hélène Gaillard et al.   NUCLEIC ACIDS RESEARCH

Structure and Assembly of the Nuclear Pore Complex

(2019) Bernhard Hampoelz et al.   Annual Review of Biophysics

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

The mTOR pathway: Implications for DNA replication

(2019) Noa Lamm et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair

(2019) Marketa Vancurova et al.   DNA REPAIR

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

(2019) Robert Lu et al.   Nature Communications

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

Insights into the non-homologous end joining pathway and double strand break end mobility provided by mechanistic in silico modelling

(2019) John W. Warmenhoven et al.   DNA REPAIR

Mobility and Repair of Damaged DNA: Random or Directed?

(2019) Roxanne Oshidari et al.   TRENDS IN CELL BIOLOGY

Telomere Loop Dynamics in Chromosome End Protection

(2018) David Van Ly et al.   MOLECULAR CELL

Break-Induced Replication: The Where, The Why, and The How

(2018) J. Kramara et al.   TRENDS IN GENETICS

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

(2018) Roxanne Oshidari et al.   Nature Communications

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes

(2017) Jaewon Min et al.   MOLECULAR AND CELLULAR BIOLOGY

The essential kinase ATR: ensuring faithful duplication of a challenging genome

(2017) Joshua C. Saldivar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-associated events affecting genomic integrity

(2017) Robin Sebastian et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

(2017) Assaf Amitai et al.   Cell Reports

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects

(2016) Noa Lamm et al.   Cell Stem Cell

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL

(2016) Chihiro Horigome et al.   GENES & DEVELOPMENT

FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway

(2016) Heather Root et al.   HUMAN MOLECULAR GENETICS

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

Chromosome territory relocation during DNA repair requires nuclear myosin 1 recruitment to chromatin mediated by ϒ-H2AX signaling

(2016) Mugdha Kulashreshtha et al.   NUCLEIC ACIDS RESEARCH

Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis

(2016) Alexandra M. Pinzaru et al.   Cell Reports

SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination

(2016) Dmitri Churikov et al.   Cell Reports

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

(2015) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

(2015) Daniel K.C. Chung et al.   Nature Communications

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice

(2014) Chihiro Horigome et al.   MOLECULAR CELL

The Spatial Organization of the Human Genome

(2013) Wendy A. Bickmore   Annual Review of Genomics and Human Genetics

Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress

(2013) Michael A. Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Distribution of directional change as a signature of complex dynamics

(2013) S. Burov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks

(2013) S. Girst et al.   Scientific Reports

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

(2012) C Lemaître et al.   ONCOGENE

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Nuclear organization in genome stability: SUMO connections

(2011) Shigeki Nagai et al.   CELL RESEARCH

De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation

(2011) I. Chung et al.   JOURNAL OF CELL SCIENCE

The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex

(2011) Jacqueline Goeres et al.   MOLECULAR BIOLOGY OF THE CELL

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

The Nuclear Envelope

(2010) M. W. Hetzer   Cold Spring Harbor Perspectives in Biology

The Cytoskeleton Protein Filamin-A Is Required for an Efficient Recombinational DNA Double Strand Break Repair

(2009) J. Yue et al.   CANCER RESEARCH

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

(2009) H. Schober et al.   GENES & DEVELOPMENT

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Dynamics of Telomeres and Promyelocytic Leukemia Nuclear Bodies in a Telomerase-negative Human Cell Line

(2009) Thibaud Jegou et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex

(2009) Basheer Khadaroo et al.   NATURE CELL BIOLOGY

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE