Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy

Microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption

(2022) Mengjie Ye et al.   CHINESE CHEMICAL LETTERS

Active Targeting Redox-Responsive Mannosylated Prodrug Nanocolloids Promote Tumor Recognition and Cell Internalization for Enhanced Colon Cancer Chemotherapy

(2022) Yuan Gao et al.   Acta Biomaterialia

Boosting ferroptosis via abplatin(iv) for treatment of platinum-resistant recurrent ovarian cancer

(2022) Wenwen Wang et al.   Nano Today

Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

(2022) Qichao Yang et al.   Acta Pharmaceutica Sinica B

Stepwise Size Shrinkage Cascade‐Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis

(2022) Meng‐Yun Liang et al.   Advanced Science

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

(2021) Kohsuke Tsuchiya   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodegradable Calcium Phosphate Nanotheranostics with Tumor‐Specific Activatable Cascade Catalytic Reactions‐Augmented Photodynamic Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED FUNCTIONAL MATERIALS

Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

(2021) Honggang Xiong et al.   ADVANCED FUNCTIONAL MATERIALS

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

The Next Decade of Immune Checkpoint Therapy

(2021) Padmanee Sharma et al.   Cancer Discovery

Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid‐Derived Suppressor Cells and Heightening Immunogenicity

(2021) Tian Zhang et al.   Small Methods

Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells

(2021) Jintao Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biodegradable Upconversion Nanoparticles Induce Pyroptosis for Cancer Immunotherapy

(2021) Binbin Ding et al.   NANO LETTERS

Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

(2021) Xianbin Ma et al.   Acta Pharmaceutica Sinica B

Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma

(2021) Di-Wei Zheng et al.   Nature Biomedical Engineering

Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy

(2020) Shiqian Gao et al.   ADVANCED MATERIALS

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

(2020) Xuexiang Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CAR T cells: continuation in a revolution of immunotherapy

(2020) Anurag K Singh et al.   LANCET ONCOLOGY

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

(2020) Chang Liu et al.   NATURE IMMUNOLOGY

Stimuli-responsive prodrug-based cancer nanomedicine

(2020) Angel Xie et al.   EBioMedicine

Role of nanoparticle-mediated immunogenic cell death in cancer immunotherapy

(2020) Yajie Sun et al.   Asian Journal of Pharmaceutical Sciences

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Indirect regulation of HMGB1 release by gasdermin D

(2020) Allen Volchuk et al.   Nature Communications

Diselenide-Linked Polymers under Sonication

(2020) Qin Wu et al.   ACS Macro Letters

Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

(2020) Shuang Bai et al.   Nano Today

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

(2019) Qian Chen et al.   ADVANCED MATERIALS

Combining Nanomedicine and Immunotherapy

(2019) Yang Shi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Selenium-Modified Microgels as Bio-Inspired Oxidation Catalysts

(2019) Kok Hui Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study

(2019) Caroline Robert et al.   LANCET ONCOLOGY

Enhancing Triple Negative Breast Cancer Immunotherapy by ICG‐Templated Self‐Assembly of Paclitaxel Nanoparticles

(2019) Bing Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies

(2019) Tianyu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

(2019) Zhiyong Wang et al.   Nature Communications

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes

(2018) Vahid Mirshafiee et al.   ACS Nano

Recent Progresses in Phototherapy-Synergized Cancer Immunotherapy

(2018) Chee Wee Ng et al.   ADVANCED FUNCTIONAL MATERIALS

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator

(2016) Gregory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

(2016) Timothy C. Johnstone et al.   CHEMICAL REVIEWS

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation

(2015) Ichiko Kinjyo et al.   Nature Communications

Selenium-Containing Polymers: Promising Biomaterials for Controlled Release and Enzyme Mimics

(2013) Huaping Xu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multi-stimuli responsive macromolecules and their assemblies

(2013) Jiaming Zhuang et al.   CHEMICAL SOCIETY REVIEWS

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Selenium and human health

(2012) Margaret P Rayman   LANCET

Polymeric micelle stability

(2012) Shawn C. Owen et al.   Nano Today

Selenium, selenoproteins and the thyroid gland: interactions in health and disease

(2011) Lutz Schomburg   Nature Reviews Endocrinology

Dual Redox Responsive Assemblies Formed from Diselenide Block Copolymers

(2009) Ning Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE