Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells

New platinum(II) complexes affecting different biomolecular targets in resistant ovarian carcinoma cells

(2021) Mariafrancesca Hyeraci et al.   ChemMedChem

A Diselenide turn‐on Fluorescent Probe for the Detection of Thioredoxin Reductase

(2020) Tendai J. Mafireyi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system

(2020) Jichun Yang et al.   BIOMATERIALS

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species

(2020) Shuai Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

(2020) Junmin Zhang et al.   MEDICINAL RESEARCH REVIEWS

Probing the Superiority of Diselenium Bond on Docetaxel Dimeric Prodrug Nanoassemblies: Small Roles Taking Big Responsibilities

(2020) Shiyi Zuo et al.   Small

Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models

(2020) Dengshuai Wei et al.   ACS Nano

Nrf2: a dark horse in Alzheimer's disease treatment

(2020) Alsiddig Osama et al.   AGEING RESEARCH REVIEWS

A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration

(2020) Chenyue Zhan et al.   BIOMATERIALS

Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases

(2020) Pengfei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers

(2019) Hideaki Ogiwara et al.   CANCER CELL

Diselenolane‐Mediated Cellular Uptake: Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein‐Coated Quantum Dots

(2019) Eline Bartolami et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

(2019) Bingjun Sun et al.   Nature Communications

A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage

(2019) Xinming Li et al.   Nature Communications

Evaluating the Protective Effects of Mitochondrial Glutathione on Cerebral Ischemia/Reperfusion Injury via Near-Infrared Fluorescence Imaging

(2019) Xia Zhang et al.   ANALYTICAL CHEMISTRY

Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies

(2019) Tianyu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells

(2018) Xinming Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy

(2018) Fuwu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Selenium versus sulfur: Reversibility of chemical reactions and resistance to permanent oxidation in proteins and nucleic acids

(2018) Michael J. Maroney et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diselenolane-mediated cellular uptake

(2018) Nicolas Chuard et al.   Chemical Science

Molecularly precise self-assembly of theranostic nanoprobes within a single-molecular framework for in vivo tracking of tumor-specific chemotherapy

(2018) Chenxu Yan et al.   Chemical Science

Selenium, Selenoproteins, and Immunity

(2018) Joseph Avery et al.   Nutrients

Selenium as a pleiotropic agent for medical discovery and drug delivery

(2018) Baozhang Guan et al.   International Journal of Nanomedicine

Prodrug approach: An overview of recent cases

(2017) Valentina Abet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

(2017) Yanqing Pang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A ratiometric fluorescent probe for imaging and quantifying anti-apoptotic effects of GSH under temperature stress

(2017) Xiaoyue Han et al.   Chemical Science

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

A Glutathione (GSH)-Responsive Near-Infrared (NIR) Theranostic Prodrug for Cancer Therapy and Imaging

(2016) Fanpeng Kong et al.   ANALYTICAL CHEMISTRY

Redox-Hypersensitive Organic Nanoparticles for Selective Treatment of Cancer Cells

(2016) Wei Zhang et al.   CHEMISTRY OF MATERIALS

Quantification of cysteine hydropersulfide with a ratiometric near-infrared fluorescent probe based on selenium–sulfur exchange reaction

(2016) Xiaoyue Han et al.   Chemical Science

A ratiometric fluorescent probe for hydrogen sulfide based on the nucleophilic substitution-cyclization of diselenides

(2015) Caihong Zhang et al.   DYES AND PIGMENTS

Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy

(2015) Inês L. Martins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

(2015) Baoxin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death

(2015) Joungyoun Noh et al.   Nature Communications

In Vivo and in Situ Tracking Cancer Chemotherapy by Highly Photostable NIR Fluorescent Theranostic Prodrug

(2014) Xumeng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selenium and selenocysteine: roles in cancer, health, and development

(2014) Dolph L. Hatfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Gemcitabine–Coumarin–Biotin Conjugates: A Target Specific Theranostic Anticancer Prodrug

(2013) Sukhendu Maiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

(2012) Min Hee Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Dual Redox Responsive Assemblies Formed from Diselenide Block Copolymers

(2009) Ning Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY