Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression

N-Acetylglucosaminyltransferase-V requires a specific non-catalytic luminal domain for its activity toward glycoprotein substrates

(2022) Reina F. Osuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

(2022) Beatrice Greco et al.   Science Translational Medicine

Glycans as Targets for Drug Delivery in Cancer

(2022) Francisca Diniz et al.   Cancers

Structure-based design of UDP-GlcNAc analogs as candidate GnT-V inhibitors

(2022) Amol M. Vibhute et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Revisiting PD-1/PD-L pathway in T and B cell response: Beyond immunosuppression

(2022) Jian Lu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

(2022) Amanda Heard et al.   Nature Communications

PI3K/Akt/mTOR signaling pathway in cancer stem cells

(2022) Mohsen Karami fath et al.   PATHOLOGY RESEARCH AND PRACTICE

Characterization of glycosylation in monoclonal antibodies and its importance in therapeutic antibody development

(2021) Harleen Kaur   CRITICAL REVIEWS IN BIOTECHNOLOGY

CAR T cells in solid tumors: challenges and opportunities

(2021) Faroogh Marofi et al.   Stem Cell Research & Therapy

Mevalonate pathway inhibition slows breast cancer metastasis via reduced N-glycosylation abundance and branching

(2021) Rosemary Yu et al.   CANCER RESEARCH

5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells

(2021) Gordon Greville et al.   Clinical Epigenetics

Small RNAs are modified with N-glycans and displayed on the surface of living cells

(2021) Ryan A. Flynn et al.   CELL

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

(2021) Emilie Marhuenda et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice

(2021) Louise van der Weyden et al.   G3-Genes Genomes Genetics

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

(2021) Louise van der Weyden et al.   Communications Biology

Glycobiology of the Epithelial to Mesenchymal Transition

(2021) Michela Pucci et al.   Biomedicines

3D Structure and Function of Glycosyltransferases Involved in N-glycan Maturation

(2020) Masamichi Nagae et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of MAN2A1 enhances tumor response to anti-PD-L1

(2020) Sailing Shi et al.   CLINICAL CANCER RESEARCH

Hypoxia Alters Epigenetic and N-Glycosylation Profiles of Ovarian and Breast Cancer Cell Lines in-vitro

(2020) Gordon Greville et al.   Frontiers in Oncology

Cancer Stem Cell Plasticity – A Deadly Deal

(2020) Archana P. Thankamony et al.   Frontiers in Molecular Biosciences

Global view of human protein glycosylation pathways and functions

(2020) Katrine T. Schjoldager et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy

(2020) Leilei Ai et al.   Drug Design Development and Therapy

Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression

(2020) Mariana C. Silva et al.   Cancer Immunology Research

Heterogeneity of Colorectal Cancer Stem Cells

(2019) Akihiro Hirata et al.   Cancer Prevention Research

GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis

(2019) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

(2019) Heng-Huan Lee et al.   CANCER CELL

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity

(2019) Xiaojuan Shi et al.   Journal of Hematology & Oncology

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

(2018) Chia-Wei Li et al.   CANCER CELL

TGF-β1 Causes EMT by Regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K Pathway in Lung Cancer

(2018) Ghulam Jilany Khan et al.   CURRENT CANCER DRUG TARGETS

Molecular targeted therapy: treating cancer with specificity

(2018) Yeuan Ting Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

N- glycosylation by N -acetylglucosaminyltransferase V enhances the interaction of CD147/basigin with integrin β1 and promotes HCC metastasis

(2018) Jian Cui et al.   JOURNAL OF PATHOLOGY

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

(2018) Ana M. Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer

(2018) Yanfeng Gao et al.   Scientific Reports

Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V

(2018) Masamichi Nagae et al.   Nature Communications

Phostine PST3.1a Targets MGAT5 and Inhibits Glioblastoma-Initiating Cell Invasiveness and Proliferation

(2017) Zahra Hassani et al.   MOLECULAR CANCER RESEARCH

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

(2017) Mizuki Nishino et al.   Nature Reviews Clinical Oncology

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

(2017) W-F Chiang et al.   ONCOGENE

Loss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis

(2017) Guodong Wang et al.   Oncotarget

Lectin from Sambucus sieboldiana abrogates the anoikis resistance of colon cancer cells conferred by N-acetylglucosaminyltransferase V during hematogenous metastasis

(2017) Kyoung Jin Song et al.   Oncotarget

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway

(2017) A Vasconcelos-dos-Santos et al.   Oncogenesis

Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased β1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding

(2016) Claudia S. Priglinger et al.   PLoS One

Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 + and CD4 + CD19-specific chimeric antigen receptor–modified T cells

(2016) Cameron J. Turtle et al.   Science Translational Medicine

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways

(2016) Michael C. Ryczko et al.   Scientific Reports

N-acetylglucosaminyltransferase V modulates radiosensitivity and migration of small cell lung cancer through epithelial-mesenchymal transition

(2015) Chunyue Huang et al.   FEBS Journal

In-depthN-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation

(2015) Manveen K Sethi et al.   GLYCOBIOLOGY

Prognostic significance of β1,6-N-acetylglucosaminyltransferase V expression in patients with hepatocellular carcinoma

(2015) Haiou Liu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

(2015) S Carvalho et al.   ONCOGENE

Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics

(2015) Alan Kirwan et al.   Biomed Research International

Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology

(2015) Jonathan J. Lyons et al.   Frontiers in Pediatrics

Inhibition of N-acetylglucosaminyltransferase V enhances sensitivity of radiotherapy in human prostate cancer

(2014) Huiyi Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation

(2014) Matthias Voss et al.   EMBO JOURNAL

Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism

(2014) Anas M Abdel Rahman et al.   GLYCOBIOLOGY

N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway

(2014) Anita Johswich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational Glycoprotein Modifications Regulate Colon Cancer Stem Cells and Colon Adenoma Progression in Apcmin/+Mice through Altered Wnt Receptor Signaling

(2014) Huabei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered β1,6-GlcNAc branchedN-glycans impair TGF-β-mediated Epithelial-to-Mesenchymal Transition through Smad signalling pathway in human lung cancer

(2014) Na Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages

(2014) D. Li et al.   JOURNAL OF IMMUNOLOGY

Serum tri- and tetra-antennaryN-glycan is a potential predictive biomarker for castration-resistant prostate cancer

(2014) Yusuke Ishibashi et al.   PROSTATE

N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells

(2013) Ju Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation

(2013) J. Liu et al.   GLYCOBIOLOGY

Dysregulation of T cell receptor N-glycosylation: a molecular mechanism involved in ulcerative colitis

(2013) Ana M. Dias et al.   HUMAN MOLECULAR GENETICS

Cell Surface Glycan Alterations in Epithelial Mesenchymal Transition Process of Huh7 Hepatocellular Carcinoma Cell

(2013) Shan Li et al.   PLoS One

Insulin/IGF-I Signaling Pathways Enhances Tumor Cell Invasion through Bisecting GlcNAc N-glycans Modulation. An Interplay with E-Cadherin

(2013) Julio Cesar Madureira de-Freitas-Junior et al.   PLoS One

Down-regulation of GnT-V enhances nasopharyngeal carcinoma cell CNE-2 radiosensitivity in vitro and in vivo

(2012) Enqing Zhuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V

(2012) Salomé S. Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A review of glycosylated carriers for drug delivery

(2012) Keerti Jain et al.   BIOMATERIALS

Physiological roles of N-acetylglucosaminyltransferase V (GnT-V) in mice

(2012) Eiji Miyoshi et al.   BMB Reports

Increased Levels of Tetra-antennary N-Linked Glycan but Not Core Fucosylation Are Associated with Hepatocellular Carcinoma Tissue

(2012) A. Mehta et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Clinical and prognostic implications of β1, 6-N-acetylglucosaminyltransferase V in patients with gastric cancer

(2012) Xuefei Wang et al.   CANCER SCIENCE

Upregulation of N-acetylglucosaminyltransferase-V by heparin-binding EGF-like growth factor induces keratinocyte proliferation and epidermal hyperplasia

(2012) Akihiro Kimura et al.   EXPERIMENTAL DERMATOLOGY

N-Acetylglucosaminyltransferase V regulates TGF-β response in hepatic stellate cells and the progression of steatohepatitis

(2012) Yoshihiro Kamada et al.   GLYCOBIOLOGY

Overexpression and β-1,6-N-Acetylglucosaminylation-initiated Aberrant Glycosylation of TIMP-1

(2012) Yong-Sam Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Epithelial-Mesenchymal Transition-like Phenotype inN-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing

(2011) Mika Terao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

(2011) George A. Khoury et al.   Scientific Reports

Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell counts

(2010) R. Saldova et al.   ANNALS OF ONCOLOGY

Inhibition of N-linked glycosylation by tunicamycin induces E-cadherin-mediated cell–cell adhesion and inhibits cell proliferation in undifferentiated human colon cancer cells

(2010) Julio Cesar Madureira de Freitas Junior et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Modulation of E-cadherin function and dysfunction by N-glycosylation

(2010) Salomé S. Pinho et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt/β-Catenin Signaling Down-regulatesN-Acetylglucosaminyltransferase III Expression

(2010) Qingsong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific posttranslational modification regulates early events in mammary carcinoma formation

(2010) H.-B. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of E-cadherin N-glycosylation profile in a mammary tumor model

(2009) Salomé S. Pinho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell Adhesion Molecules: Role and Clinical Significance in Cancer

(2009) Nektaria Makrilia et al.   CANCER INVESTIGATION

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

(2009) S. S. Pinho et al.   HUMAN MOLECULAR GENETICS

Increasing functional avidity of TCR-redirected T cells by removing definedN-glycosylation sites in the TCR constant domain

(2009) Jürgen Kuball et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

N-Glycans in cancer progression

(2008) K. S Lau et al.   GLYCOBIOLOGY

N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex

(2008) Ryota Akama et al.   PROTEOMICS

N-Glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435

(2007) Hongbo Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY