N-Glycan Remodeling on Glucagon Receptor Is an Effector of Nutrient Sensing by the Hexosamine Biosynthesis Pathway

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Encoding Asymmetry of the N-Glycosylation Motif Facilitates Glycoprotein Evolution

(2014) Ryan Williams et al.   PLoS One

Probing the Hexosamine Biosynthetic Pathway in Human Tumor Cells by Multitargeted Tandem Mass Spectrometry

(2013) Anas M. Abdel Rahman et al.   ACS Chemical Biology

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Density-dependent Lectin–Glycan Interactions as a Paradigm for Conditional Regulation by Posttranslational Modifications

(2013) James W. Dennis et al.   MOLECULAR & CELLULAR PROTEOMICS

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Targeting the glucagon receptor family for diabetes and obesity therapy

(2012) Young Min Cho et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

(2012) Gina M. Whitaker et al.   PLoS One

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

(2012) K. G. Harikumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic manifestations of insulin deficiency do not occur without glucagon action

(2012) Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

(2011) Jianxin Yang et al.   BMC GENOMICS

Protection from Obesity and Diabetes by Blockade of TGF-β/Smad3 Signaling

(2011) Hariom Yadav et al.   Cell Metabolism

N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune Encephalomyelitis

(2011) Ani Grigorian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Glycosylation Is Critical for the Stability and Intracellular Trafficking of Glucose Transporter GLUT4

(2011) Yoshimi Haga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

(2011) Kazuaki Ohtsubo et al.   NATURE MEDICINE

Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

(2010) Matthew S. Macauley et al.   CHEMISTRY & BIOLOGY

Metabolism strikes back: metabolic flux regulates cell signaling

(2010) C. M. Metallo et al.   GENES & DEVELOPMENT

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Insulin-dependent Diabetes Mellitus in Mice Does Not Alter Liver Heparan Sulfate

(2010) Joseph R. Bishop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice

(2010) Aidan S. Hancock et al.   MOLECULAR ENDOCRINOLOGY

O-GlcNAc signaling: a metabolic link between diabetes and cancer?

(2010) C. Slawson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry

(2009) Mario Pagano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Functioning and Evolutionary Significance of Nutrient Transceptors

(2009) J. M. Thevelein et al.   MOLECULAR BIOLOGY AND EVOLUTION

Growth landscape formed by perception and import of glucose in yeast

(2009) Hyun Youk et al.   NATURE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Structural and Biophysical Studies of the Human IL-7/IL-7Rα Complex

(2009) Craig A. McElroy et al.   STRUCTURE

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes

(2008) Safina Ali et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeted Glycoproteomic Identification of Biomarkers for Human Breast Carcinoma

(2008) Karen L. Abbott et al.   JOURNAL OF PROTEOME RESEARCH

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE

Hepatic Glucose Sensing via the CREB Coactivator CRTC2

(2008) R. Dentin et al.   SCIENCE