Article
Medicine, Research & Experimental
Li-Zhi Wu, You Zou, Bin-Ru Wang, Hai-Feng Ni, Yong-Gang Kong, Qing-Quan Hua, Shi-Ming Chen
Summary: Investigating the impact of CENP-N on the radiosensitivity of NPC cells, this study found that knockdown of CENP-N can enhance NPC radiosensitivity by inhibiting the AKT/mTOR pathway. The combination of CENP-N knockdown and radiotherapy showed significant suppression of proliferation, induction of apoptosis, and G2/M phase arrest in NPC cells, with increased levels of Bax and gamma H2AX proteins and decreased levels of Cyclin D1 protein.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Qianping Chen, Wang Zheng, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang, Jian Guan, Chunlin Shao
Summary: The study identified LACTB2 as a potential biomarker for radioresistance in NPC, showing that its overexpression can promote PINK1-dependent mitophagy, enhancing radioresistance.
Article
Biochemistry & Molecular Biology
Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei
Summary: This research revealed that PAD4 overexpression promotes radioresistance, survival, migration, and invasion of NPC cells, while treatment with the PAD4 inhibitor GSK484 exerted inhibitory effects on these processes. Importantly, GSK484 significantly reduced tumor size, weight, and volume in mice following irradiation, indicating its potential as a therapeutic strategy for NPC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Zhuang Sun, Xiaohui Wang, Jingyun Wang, Jing Wang, Xiao Liu, Runda Huang, Chunyan Chen, Meiling Deng, Hanyu Wang, Fei Han
Summary: This study identified 1182 differentially expressed genes between radioresistant and radiosensitive NPC tissue samples, with 22 genes upregulated and 1160 genes downregulated in the radioresistant group. Integration analysis revealed 10 major NPC radiation resistance network models, with three core genes DOCK4, MCM9, and POPDC3 identified among 12 common downregulated genes. Further experimental studies on these core genes are warranted to deepen the understanding of NPC radioresistance mechanisms.
Article
Biotechnology & Applied Microbiology
Li-Zhi Wu, Mao-Ling Huang, Cheng-Lin Qi, Li-Jun Shen, You Zou, Rui Yang, Jian-Fei Sheng, Shi-Ming Chen
Summary: Overexpression of Notch2 can increase the radiosensitivity of NPC cells by inhibiting the AKT/mTOR pathway, leading to enhanced apoptosis and cell cycle arrest in G2/M phase.
Article
Medicine, Research & Experimental
Pengfei Zhang, Yuan Shao, Fang Quan, Lifeng Liu, Jin Yang
Summary: FBP1 promotes radiosensitivity in NPC cells by inhibiting glycolysis through the FBXW7/mTOR axis.
Article
Otorhinolaryngology
Wei Zhang, Lingling Li, Ergang Guo, Haiting Zhou, Jun Ming, Lu Sun, Guoqing Hu, Linli Zhang
Summary: This study found that overexpression of PDK1 is associated with poor prognosis in nasopharyngeal carcinoma (NPC). Depletion of PDK1 can enhance the radiosensitivity of NPC cells, while a PDK1 inhibitor has the potential to enhance radiosensitivity in radioresistant NPC cells.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Biochemistry & Molecular Biology
Naoyuki Taniguchi, Yuki Ohkawa, Kento Maeda, Yoichiro Harada, Masamichi Nagae, Yasuhiko Kizuka, Hideyuki Ihara, Yoshitaka Ikeda
Summary: Cancer-related changes in glycans on cell surface proteins are regulated by glycosyltransferases and related genes, which play key roles in cancer metastasis and invasion. The significance of EMT and N-glycan branching glycosyltransferases needs to be reconsidered for potential therapeutic strategies. Specific glycosyltransferases involved in EMT or MET pathways may be difficult to define due to their roles in intermediate states.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Oncology
Xinyu Hu, Jianfeng Wu, Yong Feng, Hongxia Ma, Erbao Zhang, Chang Zhang, Qi Sun, Tingting Wang, Yizhi Ge, Dan Zong, Wei Chen, Xia He
Summary: This study found that upregulated SUCLG2-AS1 in nasopharyngeal carcinoma promotes tumor cell invasion and metastasis, while repressing apoptosis and radiosensitivity, by regulating the expression of SOX2. These findings suggest that SUCLG2-AS1 may serve as a therapeutic target for nasopharyngeal carcinoma.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Lin Shen, Chao Li, Fang Chen, Liangfang Shen, Zhanzhan Li, Na Li
Summary: The study revealed the essential role of the LUC7L2 gene in regulating radioresistance of nasopharyngeal carcinoma cells. Overexpression promoted cell viability, while knockdown slowed down DNA replication and impaired cell survival, making cells more sensitive to radiation.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Ziyan Zhou, Gang Chen, Mingjun Shen, Jixi Li, Kang Liu, Ming Liu, Shuo Shi, Wei Chen, Sixia Chen, Yuanxiu Yin, Yating Qin, Xuejin Su, Weimin Chen, Min Kang
Summary: This study screened functional genes associated with radiosensitivity and radioresistance in nasopharyngeal carcinoma (NPC) through CRISPR-Cas9 genome-scale knockout screening, laying a foundation for further research on its functional mechanisms. Eleven genes were identified, including four genes associated with radiosensitivity, two genes associated with radioresistance, as well as two potential radi-resistant genes and one potential radiosensitive gene.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Huichao Huang, Fangling Huang, Xujun Liang, Ying Fu, Zhe Cheng, Yan Huang, Zhuchu Chen, Yankun Duan, Yongheng Chen
Summary: In this study, it was discovered that afatinib enhances radio sensitivity in nasopharyngeal carcinoma (NPC) by inhibiting the CD44-Stat3 signaling pathway and the subsequent Epithelial-Mesenchymal Transition (EMT) process. Functional assays demonstrated that afatinib combined with radiation treatment significantly suppressed cell viability, migration, EMT process, and CD44-Stat3 activity in vitro and in vivo. Additionally, activation of Stat3 reversed the changes induced by afatinib, suggesting that afatinib reverses EMT process by blocking the CD44-Stat3 axis. Overall, this work reveals the molecular mechanism of afatinib as a radiation sensitizer and provides potential therapeutic strategies for NPC radiosensitization.
Article
Medicine, General & Internal
Shi-Ting Huang, Song Qu, Ling Li, Kai-Hua Chen, Xiao-Dong Zhu, Xin-Bin Pan
Summary: After studying nasopharyngeal carcinoma patients, it was found that there is a significant difference in the 5-year overall survival and cancer-specific survival rates when the maximum lymph node diameter is greater than 6 cm, thus appropriately categorizing it as stage N3 in the 8th edition American Joint Committee on Cancer staging system.
Article
Oncology
Guang-Li Zhu, Xiao-Min Zhang, Kai-Bin Yang, Ling-Long Tang, Jun Ma
Summary: This study investigated the metastatic patterns of level II-V lymph nodes in nasopharyngeal carcinoma (NPC) patients using vertebrae as anatomical landmarks. It was found that the metastasis rate gradually decreased from higher vertebral levels to lower levels. The study suggests that the clinical target volume in radiotherapy can be reduced to two vertebral levels below the metastatic level II-V nodes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Songshan Feng, Jing Li, Fan Fan, Zeyu Wang, Qian Zhang, Hao Zhang, Ziyu Dai, Xun Zhang, Peng Luo, Zaoqu Liu, Jian Zhang, Zhuoyi Liu, Quan Cheng
Summary: This study aimed to explore prognostic factors and optimal therapeutic strategy in elderly patients with MM. The findings suggest that radical tumor resection does not provide survival benefit compared to subtotal resection in elderly patients. Postoperative radiotherapy also does not significantly affect survival in this population.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yuanyuan Liu, Jingwei Zhang, Zeyu Wang, Xun Zhang, Ziyu Dai, Wantao Wu, Nan Zhang, Zaoqu Liu, Jian Zhang, Peng Luo, Zhipeng Wen, Jing Yu, Hao Zhang, Tubao Yang, Quan Cheng
Summary: This study systematically explored the prognostic and immune profile of VSIR in the tumor microenvironment of 33 cancers, and found that it is strongly correlated with the clinical outcome and tumor immunity in multiple cancer types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Weitao Shen, Peng Luo, Yueqin Sun, Wei Zhang, Ningning Zhou, Hongrui Zhan, Qingxi Zhang, Jie Shen, Anqi Lin, Quan Cheng, Qiongyao Wang, Jian Zhang, Hai-Hong Wang, Ting Wei
Summary: This study investigated the underlying mechanisms of nuclear receptor binding factor 2 (NRBF2) in chemotherapy resistance in small cell lung cancer (SCLC). It was found that NRBF2 positively regulated autophagy, leading to drug resistance in SCLC. Additionally, NRBF2 was directly modulated by the transcription factor XRCC6. These findings suggest that NRBF2 may serve as a potential therapeutic target in SCLC.
Review
Biotechnology & Applied Microbiology
Chufeng Chen, Jiaying Liu, Yidong Chen, Anqi Lin, Weiming Mou, Lingxuan Zhu, Tao Yang, Quan Cheng, Jian Zhang, Peng Luo
Summary: Researches have shown that chronic viral infection and persistent exposure to antigens and/or inflammatory signals in cancer can lead to T cell exhaustion due to major changes in the epigenetic and metabolic environment. The discovery of the immune checkpoint pathway has been a significant milestone in understanding and reversing T cell exhaustion. Antibodies targeting these pathways have demonstrated superior capability in reversing T cell exhaustion. However, immune checkpoint blocking therapy still has limitations, such as short-term therapeutic effects and high individual heterogeneity. Assay for transposase-accessible chromatin with sequencing (ATAC-seq) is a method that can analyze the accessibility of whole-genome chromatin. Increasing studies have reported that ATAC-seq can characterize the dynamic changes of epigenetics in T cell exhaustion. It has been found that immune checkpoint blocking therapy can only temporarily restore the function of exhausted T cells due to irreversible changes in their epigenetics. In this study, we review the latest developments that provide a clearer molecular understanding of T cell exhaustion, reveal potential new therapeutic targets for persistent viral infection and cancer, and offer new insights for designing effective immunotherapy for cancer and chronic infection.
CANCER GENE THERAPY
(2023)
Article
Oncology
Zaoqu Liu, Hui Xu, Siyuan Weng, Chunguang Guo, Qin Dang, Yuyuan Zhang, Yuqing Ren, Long Liu, Libo Wang, Xiaoyong Ge, Zhe Xing, Jian Zhang, Peng Luo, Xinwei Han
Summary: A machine learning-based prognostic signature (MLPS) has been developed to predict the prognosis of melanoma patients, showing superior predictive performance compared to clinical traits and other collected signatures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Tianqi Gu, Aimin Jiang, Chaozheng Zhou, Anqi Lin, Quan Cheng, Zaoqu Liu, Jian Zhang, Peng Luo
Summary: This study aims to determine the safety of immune checkpoint inhibitors combined with the anti-angiogenesis drug bevacizumab through a large-scale retrospective analysis of adverse drug reactions (ADRs). The risk of ADRs such as interstitial lung disease, hypertension, and gastrointestinal bleeding was found to be elevated in patients receiving combination therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Chunrun Qu, Hao Zhang, Hui Cao, Lanhua Tang, Haoyang Mo, Fangkun Liu, Liyang Zhang, Zhenjie Yi, Lifu Long, Luzhe Yan, Zeyu Wang, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Weijie Ye, Zhixiong Liu, Quan Cheng
Summary: Chimeric antigen receptor (CAR) T cell therapy based on gene editing technology is a significant breakthrough in personalized immunotherapy for human cancer. It enables T cells to target tumor-specific antigens and attack cancer cells, bypassing tumor cell apoptosis avoidance mechanisms to some extent. However, tumor antigen escape, treatment-related toxicity, and the immunosuppressive tumor microenvironment limit its effectiveness in solid tumor treatment.
Article
Oncology
Hao Zhang, Nan Zhang, Ziyu Dai, Zeyu Wang, Xun Zhang, Xisong Liang, Liyang Zhang, Songshan Feng, Wantao Wu, Weijie Ye, Jian Zhang, Peng Luo, Zaoqu Liu, Quan Cheng, Zhixiong Liu
Summary: This study systematically evaluated the relationship between the metabolic pattern of gliomas and patient survival outcome and immune activity. The results identified three distinct metabolic phenotypes and revealed the important role of hyaluronic acid (HA) in glioma proliferation, progression, invasion, and immune infiltration. HA was found to potentially regulate macrophage recruitment, M2 polarization, and the expression of PD-L1 in gliomas.
MOLECULAR ONCOLOGY
(2022)
Article
Immunology
Zicheng Wang, Xisong Liang, Hao Zhang, Zeyu Wang, Xun Zhang, Ziyu Dai, Zaoqu Liu, Jian Zhang, Peng Luo, Jiarong Li, Quan Cheng
Summary: This study aimed to investigate the effects of hypoxia and angiogenesis on gastric cancer and establish a related model. The results showed that the model could accurately predict patient survival and was associated with the staging of gastric cancer. Various cancer-associated pathways and macrophage-related regulations were upregulated in the high-HARM group. The high-HARM group also exhibited higher immune levels and increased infiltration of M2 macrophages and cancer-associated fibroblasts. Additionally, globally upregulated immune checkpoints and higher TIDE scores were observed in the high-HARM group. Eight drugs with lower IC50 in the high-HARM group were identified as potential drugs for HARM-targeted therapy.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Zeyu Wang, Ziyu Dai, Hao Zhang, Nan Zhang, Xisong Liang, Luo Peng, Jian Zhang, Zaoqu Liu, Yun Peng, Quan Cheng, Zhixiong Liu
Summary: In this study, we collected 73 GBM samples and found that the different subtypes of GBM have different prognoses. We also discovered the association between pyroptosis and tumor-microglia interaction and the tumor response to interferon-gamma. Based on pyroptosis-related genes, we grouped GBM samples into cluster 1 and cluster 2, with cluster 1 samples showing worse prognosis and a more complex immune landscape. Machine learning algorithms identified nutlin-3 as a potential treatment for cluster 1 samples.
CELL PROLIFERATION
(2023)
Article
Oncology
Jiexia Zhang, Ningning Zhou, Huojin Deng, Xin Chen, Qunqing Chen, Qiongyao Wang, Lei Sun, Yang Wen, Xiaolong Cao, Zhiqiang Luo, Jian Zhang, Weiliang Zhu, Linlang Guo
Summary: This study used liquid biopsies to monitor and analyze plasma samples from patients with extensive-stage SCLC, and found that ctDNA levels can reflect tumor burden and predict progression-free survival. The study also demonstrated that plasma ctDNA assays can provide real-time information on somatic mutations for potential targeted therapies for SCLC.
Editorial Material
Immunology
Clare Y. Slaney, Peng Luo, Feng-Ming Kong, Linlang Guo, Jian Zhang
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chong-Rui Xu, Qixun Chen, Chengzhi Zhou, Lin Wu, Wen Li, Huizhong Zhang, Yongsheng Li, Fei Xu, Jianping Xiong, Qiming Wang, Haibo Zhang, Yuequan Jiang, Haitao Yin, Qingchen Wu, Qiangsheng Dai, Jian Hu, Jianhua Chen, Jian Zhang, Gang Wu, Jun Yin, Jianfu Zhao, Baogang Liu, Jianzhen Shan, Liming Sheng, Qunqing Chen, Zhengxiang Han, Huaqiu Shi, Yimin Liu, Jun Chen, Yi-Long Wu
Summary: This study aimed to investigate the real-world effectiveness and safety of camrelizumab in inoperable or advanced non-small cell lung cancer (NSCLC) patients. The results showed that the objective response rate of camrelizumab was 40.2%, disease control rate was 85.1%, and 6-month progression-free survival and overall survival rates were 73.0% and 93.1%, respectively. The presence of liver metastasis and longer duration of treatment were associated with worse outcomes.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang, Peng Luo
Summary: As a nontraditional T-cell subgroup, gamma delta T cells have shown great potential in immunotherapy for tumors. Immune checkpoint inhibitors (ICIs) have become pioneer drugs in tumor immunotherapy, and studies have shown that targeting ICs can reverse the dysfunctional state of gamma delta T cells in the tumor microenvironment and enhance their antitumor effects. Understanding the functional state of gamma delta T cells and their interaction with ICs will solidify ICIs combined with gamma delta T cells as a viable treatment option.
Article
Immunology
Rui Chen, Wantao Wu, Tao Liu, Yihan Zhao, Yifan Wang, Hao Zhang, Zeyu Wang, Ziyu Dai, Xiaoxi Zhou, Peng Luo, Jian Zhang, Zaoqu Liu, Li-Yang Zhang, Quan Cheng
Summary: This study suggests that mast cells play a potential effective prognostic factor in gliomas. Using mast cell-related genes, gliomas can be divided into clusters with distinct clinical and immunological characteristics, and cluster 1 has significantly lower survival probability than cluster 2. Additionally, the hypoxic and metabolic pathways are active in cluster 1, promoting tumor cell proliferation. By constructing a prognostic model and using machine learning, DRG2 was identified as a characteristic gene that can predict treatment response and survival outcome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
