Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition

Active conformation of the p97-p47 unfoldase complex

(2022) Yang Xu et al.   Nature Communications

Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1

(2022) Michael Prattes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved L464 in p97 D1–D2 linker is critical for p97 cofactor regulated ATPase activity

(2021) Xiaoyi Zhang et al.   BIOCHEMICAL JOURNAL

Mechanisms of hexameric helicases

(2021) Amy J. Fernandez et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Common mutations of AAA ATPase p97 and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation

(2021) Brian Caffrey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic insight into substrate processing and allosteric inhibition of human p97

(2021) Man Pan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

(2021) Michael Prattes et al.   Nature Communications

Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates**

(2021) João P. M. António et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines

(2021) Yousuf A. Khan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis

(2020) Kyle E. Lopez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cutting, Amplifying, and Aligning Microtubules with Severing Enzymes

(2020) Yin-Wei Kuo et al.   TRENDS IN CELL BIOLOGY

Progress in the medicinal chemistry of organoboron compounds

(2020) Anna N. Tevyashova et al.   RUSSIAN CHEMICAL REVIEWS

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

(2019) Yu-Hua Lo et al.   Nature Communications

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

(2019) Alexandrea N. Rizo et al.   Nature Communications

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

(2019) Stephanie N. Gates et al.   PROTEIN SCIENCE

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Compound heterozygous SPATA5 variants in four families and functional studies of SPATA5 deficiency

(2018) Sanna Puusepp et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

(2018) Nicholas O. Bodnar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structural principles of SNARE complex recognition by the AAA+ protein NSF

(2018) K Ian White et al.   eLife

Ribosome assembly coming into focus

(2018) Sebastian Klinge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Viewing pre-60S maturation at a minute’s timescale

(2017) Gertrude Zisser et al.   NUCLEIC ACIDS RESEARCH

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48

(2017) Masatoshi Esaki et al.   Scientific Reports

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine

(2016) Dominik Barthelme et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes

(2016) Shan Wu et al.   NATURE

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97

(2016) Petra Hänzelmann et al.   STRUCTURE

Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain

(2016) Wai Kwan Tang et al.   Scientific Reports

Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss

(2015) Akemi J. Tanaka et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Synthesis, Characterisation, and Antifungal Activities of Novel Benzodiazaborines

(2015) Jiyoung Yang et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Mechanistic insights into the recycling machine of the SNARE complex

(2015) Minglei Zhao et al.   NATURE

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosome Biogenesis in the Yeast Saccharomyces cerevisiae

(2013) John L. Woolford et al.   GENETICS

The Drug Diazaborine Blocks Ribosome Biogenesis by Inhibiting the AAA-ATPase Drg1

(2013) Mathias Loibl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scalable web services for the PSIPRED Protein Analysis Workbench

(2013) Daniel W. A. Buchan et al.   NUCLEIC ACIDS RESEARCH

Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation

(2012) Lisa Kappel et al.   JOURNAL OF CELL BIOLOGY

Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97

(2012) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The power of AAA-ATPases on the road of pre-60S ribosome maturation — Molecular machines that strip pre-ribosomal particles

(2011) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cdc48: a power machine in protein degradation

(2011) Alexandra Stolz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A novel ATP-dependent conformation in p97 N–D1 fragment revealed by crystal structures of disease-related mutants

(2010) Wai Kwan Tang et al.   EMBO JOURNAL

Defining the Pathway of Cytoplasmic Maturation of the 60S Ribosomal Subunit

(2010) Kai-Yin Lo et al.   MOLECULAR CELL

The AAA-ATPase Rea1 Drives Removal of Biogenesis Factors during Multiple Stages of 60S Ribosome Assembly

(2010) Jochen Baßler et al.   MOLECULAR CELL

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Driving ribosome assembly

(2009) Dieter Kressler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanochemical Removal of Ribosome Biogenesis Factors from Nascent 60S Ribosomal Subunits

(2009) Cornelia Ulbrich et al.   CELL

An Intersubunit Signaling Network Coordinates ATP Hydrolysis by m-AAA Proteases

(2009) Steffen Augustin et al.   MOLECULAR CELL

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Powering through ribosome assembly

(2009) B. S. Strunk et al.   RNA

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase

(2008) Louise C. Briggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles

(2008) Dieter Kressler et al.   JOURNAL OF CELL BIOLOGY