Active conformation of the p97-p47 unfoldase complex

Mechanistic insight into substrate processing and allosteric inhibition of human p97

(2021) Man Pan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

(2020) Xue Fei et al.   eLife

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

(2020) Lan Wang et al.   eLife

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets

(2020) Denisa Bojkova et al.   NATURE

An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase

(2020) Alexander E. Conicella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4

(2019) Han Han et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

(2019) Yu-Hua Lo et al.   Nature Communications

An allosteric network in spastin couples multiple activities required for microtubule severing

(2019) Colby R. Sandate et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

(2019) Han Han et al.   eLife

Katanin Grips the β-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules

(2019) Elena A. Zehr et al.   DEVELOPMENTAL CELL

Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation

(2019) Han Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone

(2019) Carol Cho et al.   Nature Communications

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

(2018) Johannes van den Boom et al.   MOLECULAR CELL

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

(2018) Matthias Weith et al.   MOLECULAR CELL

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Cooperative subunit dynamics modulate p97 function

(2018) Rui Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines

(2017) Adrian O. Olivares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy

(2017) Emily E. Blythe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution

(2017) Shan Sun et al.   Nature Communications

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

(2017) Han Han et al.   eLife

Structure of a AAA+ unfoldase in the process of unfolding substrate

(2017) Zev A Ripstein et al.   eLife

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

(2017) Nicole Monroe et al.   eLife

Mechanism of Vps4 hexamer function revealed by cryo-EM

(2017) Min Su et al.   Science Advances

Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48

(2017) Masatoshi Esaki et al.   Scientific Reports

2.3 A resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition

(2016) S. Banerjee et al.   SCIENCE

Abstract DDT02-01: Inhibition of the AAA-ATPase p97 with the first in class inhibitor CB-5083 as a novel approach to treat cancer

(2015) Daniel J. Anderson et al.   CANCER RESEARCH

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO

(2012) Yuri Shibata et al.   Nature Communications

PEAKS DB:De NovoSequencing Assisted Database Search for Sensitive and Accurate Peptide Identification

(2011) Jing Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: Review of a unique disorder

(2008) Virginia E. Kimonis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE