Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

(2019) Yu-Hua Lo et al.   Nature Communications

Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease

(2019) Cristina Puchades et al.   MOLECULAR CELL

An allosteric network in spastin couples multiple activities required for microtubule severing

(2019) Colby R. Sandate et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

(2019) Alexandrea N. Rizo et al.   Nature Communications

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

(2019) Célia Deville et al.   Cell Reports

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

(2019) Han Han et al.   eLife

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Malaria parasite translocon structure and mechanism of effector export

(2018) Chi-Min Ho et al.   NATURE

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

(2018) Hongjun Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural principles of SNARE complex recognition by the AAA+ protein NSF

(2018) K Ian White et al.   eLife

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Katanin spiral and ring structures shed light on power stroke for microtubule severing

(2017) Elena Zehr et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Katanin spiral and ring structures shed light on power stroke for microtubule severing

(2017) Elena Zehr et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

(2017) Han Han et al.   eLife

Structure of a AAA+ unfoldase in the process of unfolding substrate

(2017) Zev A Ripstein et al.   eLife

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

(2017) Nicole Monroe et al.   eLife

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase

(2017) Célia Deville et al.   Science Advances

Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48

(2017) Masatoshi Esaki et al.   Scientific Reports

Review: Progresses in understanding N-ethylmaleimide sensitive factor (NSF) mediated disassembly of SNARE complexes

(2016) Je-Kyung Ryu et al.   BIOPOLYMERS

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX

(2015) Benjamin M Stinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX

(2015) Benjamin M Stinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

(2014) Juan Carlos Cordova et al.   CELL

The ClpXP Protease Unfolds Substrates Using a Constant Rate of Pulling but Different Gears

(2013) Maya Sen et al.   CELL

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

(2013) Benjamin M. Stinson et al.   CELL

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase

(2013) Robyn Beckwith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Marching to the beat of the ring: polypeptide translocation by AAA+ proteases

(2013) Kristofor Nyquist et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation

(2012) Ornchuma Itsathitphaisarn et al.   CELL

Structure and function of the AAA+ nucleotide binding pocket

(2011) Petra Wendler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine

(2011) Marie-Eve Aubin-Tam et al.   CELL

ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates

(2011) Rodrigo A. Maillard et al.   CELL

Regulatory Circuits of the AAA+ Disaggregase Hsp104

(2011) Titus M. Franzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

(2011) B. A. Kelch et al.   SCIENCE

Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases

(2009) Nathan D. Thomsen et al.   CELL

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

(2009) Kyle R. Simonetta et al.   CELL

An Intersubunit Signaling Network Coordinates ATP Hydrolysis by m-AAA Proteases

(2009) Steffen Augustin et al.   MOLECULAR CELL

Mechanism of Substrate Unfolding and Translocation by the Regulatory Particle of the Proteasome from Methanocaldococcus jannaschii

(2009) Fan Zhang et al.   MOLECULAR CELL

AAA+ ATPases in the Initiation of DNA Replication

(2008) Karl E. Duderstadt et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Diverse Pore Loops of the AAA+ ClpX Machine Mediate Unassisted and Adaptor-Dependent Recognition of ssrA-Tagged Substrates

(2008) Andreas Martin et al.   MOLECULAR CELL

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY