The NLRP3 inflammasome: regulation by metabolic signals

Inflammasome activation and pyroptosis via a lipid-regulated SIRT1-p53-ASC axis in macrophages from male mice and humans

(2022) Yimao Huang et al.   ENDOCRINOLOGY

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

(2022) Christopher Hoyle et al.   IMMUNOLOGY

Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis

(2022) Aakriti Jain et al.   Molecular Metabolism

Host succinate is an activation signal for Salmonella virulence during intracellular infection

(2021) Gili Rosenberg et al.   SCIENCE

DHA/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly

(2021) Guoqiang Fan et al.   Cell Death & Disease

Itaconate confers tolerance to late NLRP3 inflammasome activation

(2021) Monika Bambouskova et al.   Cell Reports

Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation

(2021) Philipp J. Hohensinner et al.   BIOCHEMICAL PHARMACOLOGY

Sphingolipid metabolism during Toll‐like receptor 4 (TLR4)‐mediated macrophage activation

(2021) Antoni Olona et al.   BRITISH JOURNAL OF PHARMACOLOGY

Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

(2021) Xiaopeng Li et al.   Cell Reports

ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation

(2021) Dongsheng Bai et al.   Autophagy

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

(2021) Thomas Laval et al.   eLife

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Lipids, inflammasomes, metabolism, and disease

(2020) Paras K. Anand   IMMUNOLOGICAL REVIEWS

Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

(2020) Wei Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Triacylglycerol synthesis enhances macrophage inflammatory function

(2020) Angela Castoldi et al.   Nature Communications

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Central metabolic interactions of immune cells and microbes: prospects for defeating infections

(2019) Ana Traven et al.   EMBO REPORTS

Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal

(2019) Kathryn A. Wierenga et al.   Frontiers in Immunology

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

(2019) Wei-Chen Yen et al.   Redox Biology

Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights

(2018) Tadayoshi Karasawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

(2018) Christopher J. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

(2018) Sujun Li et al.   MOLECULAR MEDICINE

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation

(2018) Marianne de la Roche et al.   JOURNAL OF CELL BIOLOGY

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly

(2017) Mahmoud ElAzzouny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy

(2017) Lulu Shen et al.   JOURNAL OF LIPID RESEARCH

Immunity to uropathogens: the emerging roles of inflammasomes

(2017) Claire Hamilton et al.   Nature Reviews Urology

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

Integrating Inflammasome Signaling in Sexually Transmitted Infections

(2016) Christopher Lupfer et al.   TRENDS IN IMMUNOLOGY

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

(2015) Javier Traba et al.   JOURNAL OF CLINICAL INVESTIGATION

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

(2014) D J Roberts et al.   CELL DEATH AND DIFFERENTIATION

Oxidative metabolism enablesSalmonellaevasion of the NLRP3 inflammasome

(2014) Meghan A. Wynosky-Dolfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

(2014) Alexander A Shestov et al.   eLife

Autophagy ModulatesBorrelia burgdorferi-induced Production of Interleukin-1β (IL-1β)

(2013) Kathrin Buffen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

(2013) Laurent L'homme et al.   JOURNAL OF LIPID RESEARCH

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Receptor interacting protein kinase 2–mediated mitophagy regulates inflammasome activation during virus infection

(2013) Christopher Lupfer et al.   NATURE IMMUNOLOGY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Nlrp3 Inflammasome in Microbial Infection

(2011) Paras K. Anand et al.   Frontiers in Microbiology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Glucose and Glycolysis Are Required for the Successful Infection of Macrophages and Mice by Salmonella enterica Serovar Typhimurium

(2009) S. D. Bowden et al.   INFECTION AND IMMUNITY

Virulence determinants from a cystic fibrosis isolate of Pseudomonas aeruginosa include isocitrate lyase

(2008) T. L. Lindsey et al.   MICROBIOLOGY-SGM