Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

Pt Decorated Ti3C2Tx MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics

(2022) Yanlin Zhu et al.   ACS Nano

Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer

(2022) Gaorui Zhang et al.   Acta Biomaterialia

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

(2022) Tara E. Tracy et al.   CELL

Re-engineering the inner surface of ferritin nanocage enables dual drug payloads for synergistic tumor therapy

(2022) Zhuoran Wang et al.   Theranostics

Tumor microenvironment responsive self-cascade catalysis for synergistic chemo/chemodynamic therapy by multifunctional biomimetic nanozymes

(2022) Nannan Zheng et al.   Journal of Materials Chemistry B

Targeted killing of tumor cells based on isoelectric point suitable nanoceria-rod with high oxygen vacancies

(2022) Baofu Ma et al.   Journal of Materials Chemistry B

CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy

(2022) Dan Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

(2022) Muxue Wang et al.   Bioactive Materials

Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing

(2022) Xingjun Zhao et al.   ACS Applied Materials & Interfaces

Iron Phosphate Nanozyme–Hydrogel with Multienzyme-like Activity for Efficient Bacterial Sterilization

(2022) Zi-Yang Liao et al.   ACS Applied Materials & Interfaces

Preparation of Two-Dimensional Pd@Ir Nanosheets and Application in Bacterial Infection Treatment by the Generation of Reactive Oxygen Species

(2022) Zichen Ye et al.   ACS Applied Materials & Interfaces

Degradable Tumor-Responsive Iron-Doped Phosphate-Based Glass Nanozyme for H2O2 Self-Supplying Cancer Therapy

(2022) Yuan Yao et al.   ACS Applied Materials & Interfaces

Piezoelectric Activatable Nanozyme-Based Skin Patch for Rapid Wound Disinfection

(2022) Qiang Bai et al.   ACS Applied Materials & Interfaces

Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

(2022) Feng Wu et al.   ACS Nano

How to Define a Nanozyme

(2022) Anne Robert et al.   ACS Nano

Prussian Blue Nanozyme Promotes the Survival Rate of Skin Flaps by Maintaining a Normal Microenvironment

(2022) Rui Hou et al.   ACS Nano

Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity

(2022) Lu Yao et al.   ACS Nano

Iron phthalocyanine-derived nanozyme as dual reactive oxygen species generation accelerator for photothermally enhanced tumor catalytic therapy

(2022) Fuchun Nan et al.   BIOMATERIALS

Nanoarchitectonics with metal-organic frameworks and platinum nanozymes with improved oxygen evolution for enhanced sonodynamic/chemo-therapy

(2022) Qian Ren et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Simulated Enzyme Activity and Efficient Antibacterial Activity of Copper-Doped Single-Atom Nanozymes

(2022) Junrun Zhu et al.   LANGMUIR

Polydopamine-Based Nanocomposite as a Biomimetic Antioxidant with a Variety of Enzymatic Activities for Parkinson’s Disease

(2022) Wei Wang et al.   ACS Applied Materials & Interfaces

Development of an Au-anchored Fe Single-atom nanozyme for biocatalysis and enhanced tumor photothermal therapy

(2022) Na Feng et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Engineering efficient artificial nanozyme based on chitosan grafted Fe-doped-carbon dots for bacteria biofilm eradication

(2022) Ting Pan et al.   JOURNAL OF HAZARDOUS MATERIALS

Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway

(2022) Pir Muhammad et al.   Nano Today

Liquid exfoliation of V8C7 nanodots as peroxidase-like nanozymes for photothermal-catalytic synergistic antibacterial treatment

(2022) Yan Ma et al.   Acta Biomaterialia

A hyaluronic acid/platelet-rich plasma hydrogel containing MnO2 nanozymes efficiently alleviates osteoarthritis in vivo

(2022) Tong Zhou et al.   CARBOHYDRATE POLYMERS

Engineering oxygen vacancy of MoOx nanoenzyme by Mn doping for dual-route cascaded catalysis mediated high tumor eradication

(2022) Rui Zhang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Bimetallic oxide nanozyme-mediated depletion of glutathione to boost oxidative stress for combined nanocatalytic therapy

(2022) Siyi Li et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Blocking glutathione regeneration: Inorganic NADPH oxidase nanozyme catalyst potentiates tumoral ferroptosis

(2022) Chenyao Wu et al.   Nano Today

A biomimetic nanocomposite with enzyme-like activities and CXCR4 antagonism efficiently enhances the therapeutic efficacy of acute myeloid leukemia

(2022) Fei Kong et al.   Bioactive Materials

Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration

(2022) Zhicheng Cao et al.   Bioactive Materials

A framework to predict the price of energy for the end-users with applications to monetary and energy policies

(2021) Stefanos G. Baratsas et al.   Nature Communications

Metallic Graphene Nanoribbons

(2021) Sheng-Yi Xie et al.   Nano-Micro Letters

Multienzymes activity of metals and metal oxide nanomaterials: applications from biotechnology to medicine and environmental engineering

(2021) Negar Alizadeh et al.   JOURNAL OF NANOBIOTECHNOLOGY

Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

(2021) Changzhen Sun et al.   JOURNAL OF NANOBIOTECHNOLOGY

Strategy for Treatment of Infected Diabetic Foot Ulcers

(2021) Mayland Chang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effective Antibacterial Activity of Degradable Copper-Doped Phosphate-Based Glass Nanozymes

(2021) Yifan Liu et al.   ACS Applied Materials & Interfaces

Ultrasmall FeS 2 Nanoparticles‐Decorated Carbon Spheres with Laser‐Mediated Ferrous Ion Release for Antibacterial Therapy

(2021) Juqun Xi et al.   Small

Innate tumor-targeted nanozyme overcoming tumor hypoxia for cancer theranostic use

(2021) Hanitrarimalala Veroniaina et al.   Journal of Advanced Research

PD-L1 immunohistochemistry for canine cancers and clinical benefit of anti-PD-L1 antibody in dogs with pulmonary metastatic oral malignant melanoma

(2021) Naoya Maekawa et al.   npj Precision Oncology

Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

(2021) Mengyu Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inflammatory microenvironment-targeted nanotherapies

(2021) Guangshuai Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing

(2021) Yang Li et al.   Bioactive Materials

Regression with linked datasets subject to linkage error

(2021) Zhenbang Wang et al.   Wiley Interdisciplinary Reviews-Computational Statistics

Tumor Microenvironment-Activated Theranostics Nanozymes for Fluorescence Imaging and Enhanced Chemo-Chemodynamic Therapy of Tumors

(2021) Dong-Hui Zhao et al.   ACS Applied Materials & Interfaces

A pH-Responsive Persistent Luminescence Nanozyme for Selective Imaging and Killing of Helicobacter pylori and Common Resistant Bacteria

(2021) Li-Xia Yan et al.   ACS Applied Materials & Interfaces

Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy

(2021) Ye Zhang et al.   ACS Applied Materials & Interfaces

Chemically Grafted Nanozyme Composite Cryogels to Enhance Antibacterial and Biocompatible Performance for Bioliquid Regulation and Adaptive Bacteria Trapping

(2021) Yanyan Li et al.   ACS Nano

A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

(2021) Na Tao et al.   ACS Nano

Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes

(2021) Weiyun Zhang et al.   ACS Nano

Multifunctional Nanozyme Hydrogel with Mucosal Healing Activity for Single-Dose Ulcerative Colitis Therapy

(2021) Chaoqun Cheng et al.   BIOCONJUGATE CHEMISTRY

Bioadhesive injectable hydrogel with phenolic carbon quantum dot supported Pd single atom nanozymes as a localized immunomodulation niche for cancer catalytic immunotherapy

(2021) Huan He et al.   BIOMATERIALS

Dual enzyme-mimic nanozyme based on single-atom construction strategy for photothermal-augmented nanocatalytic therapy in the second near-infrared biowindow

(2021) Yutian Su et al.   BIOMATERIALS

Enzyme-mimicking capacities of carbon-dots nanozymes: Properties, catalytic mechanism, and applications – A review

(2021) Diana Ofelia Lopez-Cantu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cationic chitosan@Ruthenium dioxide hybrid nanozymes for photothermal therapy enhancing ROS-mediated eradicating multidrug resistant bacterial infection

(2021) Xufeng Zhu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Nanoceria, the versatile nanoparticles: Promising biomedical applications

(2021) Mohd Aslam Saifi et al.   JOURNAL OF CONTROLLED RELEASE

Photothermal nanozyme-ignited Fenton reaction-independent ferroptosis for breast cancer therapy

(2021) Lei Xing et al.   JOURNAL OF CONTROLLED RELEASE

Ferumoxytol Nanoparticles Target Biofilms Causing Tooth Decay in the Human Mouth

(2021) Yuan Liu et al.   NANO LETTERS

Pathogen Receptor Membrane-Coating Facet Structures Boost Nanomaterial Immune Escape and Antibacterial Performance

(2021) Xuan Hou et al.   NANO LETTERS

A Biofilm Microenvironment‐Activated Single‐Atom Iron Nanozyme with NIR‐Controllable Nanocatalytic Activities for Synergetic Bacteria‐Infected Wound Therapy

(2021) Qiqi Xu et al.   Advanced Healthcare Materials

Precise Thermoplastic Processing of Graphene Oxide Layered Solid by Polymer Intercalation

(2021) Zeshen Li et al.   Nano-Micro Letters

High-Porosity Foam-Based Iontronic Pressure Sensor with Superhigh Sensitivity of 9280 kPa−1

(2021) Qingxian Liu et al.   Nano-Micro Letters

Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury

(2021) Renyikun Yuan et al.   ACS Central Science

Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing

(2021) Yunhang Liu et al.   Bioactive Materials

Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection

(2020) Duo Sun et al.   ACS Nano

An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

(2020) Fangfang Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Reply to: On the signature of a 70-solar-mass black hole in LB-1

(2020) Jifeng Liu et al.   NATURE

Killing cancer cells by rupturing their lysosomes

(2020) Jichuan Qiu et al.   Nature Nanotechnology

Biofilm Matrixome: Extracellular Components in Structured Microbial Communities

(2020) L. Karygianni et al.   TRENDS IN MICROBIOLOGY

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

(2020) Jinchao Shen et al.   BIOMATERIALS

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Artificial Organelles Based on Cross-Linked Zwitterionic Vesicles

(2020) Yun Chen et al.   NANO LETTERS

Ligand‐dependent activity engineering of glutathione peroxidase‐mimicking MIL‐47(V) metal–organic framework nanozyme for therapy

(2020) Jiangjiexing Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold Nanozymes: From Concept to Biomedical Applications

(2020) Javier Lou-Franco et al.   Nano-Micro Letters

Dextran Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

(2019) Pratap C Naha et al.   ACS Nano

Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway

(2019) Gang Wang et al.   Molecular Cancer

Recent Progress on Engineering Highly Efficient Porous Semiconductor Photocatalysts Derived from Metal–Organic Frameworks

(2019) Wenwen Zhan et al.   Nano-Micro Letters

Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis

(2019) Xiaoduan Sun et al.   JOURNAL OF NANOBIOTECHNOLOGY

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

(2019) Yanyan Huang et al.   CHEMICAL REVIEWS

Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief

(2019) Conghui Liu et al.   ACS Nano

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Reversible and cooperative photoactivation of single-atom Cu/TiO2 photocatalysts

(2019) Byoung-Hoon Lee et al.   NATURE MATERIALS

Boosting Electrocatalytic Hydrogen Evolution over Metal-Organic Frameworks by Plasmon-Induced Hot-Electron Injection

(2019) Shan-Shan Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria

(2019) Zhengwei Liu et al.   BIOMATERIALS

Defect-Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition

(2019) Fangfang Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper/Carbon Hybrid Nanozyme: Tuning Catalytic Activity by the Copper State for Antibacterial Therapy

(2019) Juqun Xi et al.   NANO LETTERS

Multicomponent Plasmonic Nanoparticles: From Heterostructured Nanoparticles to Colloidal Composite Nanostructures

(2019) Minji Ha et al.   CHEMICAL REVIEWS

Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

(2019) Xi Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Prussian Blue Nanozyme with Multi-enzyme Activity Reduces Colitis in Mice

(2018) Jiulong Zhao et al.   ACS Applied Materials & Interfaces

Selenium-Based Nanozyme as Biomimetic Antioxidant Machinery

(2018) Yanyan Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells

(2018) James A. Vassie et al.   MOLECULAR PHARMACEUTICS

Metabolic rate evolves rapidly and in parallel with the pace of life history

(2018) Sonya K. Auer et al.   Nature Communications

Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine

(2018) Erin S. Calipari et al.   Nature Communications

Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase-Like Activity and Metabolic Regulation

(2018) Chaoxiu Ren et al.   Advanced Science

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

Ultrasmall Nanozymes Isolated within Porous Carbonaceous Frameworks for Synergistic Cancer Therapy: Enhanced Oxidative Damage and Reduced Energy Supply

(2018) Fangfang Cao et al.   CHEMISTRY OF MATERIALS

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

Chiral Molecule-mediated Porous CuxO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson’s Disease

(2018) Changlong Hao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

Biofilm-related disease

(2017) Jose Luis Del Pozo   Expert Review of Anti-Infective Therapy

Correction to Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2016) Manli Song et al.   ACS Nano

Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage

(2016) Cuicui Ge et al.   ACS Nano

A Multinuclear Metal Complex Based DNase-Mimetic Artificial Enzyme: Matrix Cleavage for Combating Bacterial Biofilms

(2016) Zhaowei Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

(2016) Yanyan Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human disorders of peroxisome metabolism and biogenesis

(2016) Hans R. Waterham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bacterial Contribution in Chronicity of Wounds

(2016) Kashif Rahim et al.   MICROBIAL ECOLOGY

Rationally Modulate the Oxidase-like Activity of Nanoceria for Self-Regulated Bioassays

(2016) Hanjun Cheng et al.   ACS Sensors

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Bifunctionalized Mesoporous Silica-Supported Gold Nanoparticles: Intrinsic Oxidase and Peroxidase Catalytic Activities for Antibacterial Applications

(2014) Yu Tao et al.   ADVANCED MATERIALS

Nano-Gold as Artificial Enzymes: Hidden Talents

(2014) Youhui Lin et al.   ADVANCED MATERIALS

Acquired Superoxide-Scavenging Ability of Ceria Nanoparticles

(2014) Yuanyuan Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Self-Catalyzed, Self-Limiting Growth of Glucose Oxidase-Mimicking Gold Nanoparticles

(2010) Weijie Luo et al.   ACS Nano

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE