Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

(2022) Yaqian Du et al.   ADVANCED FUNCTIONAL MATERIALS

High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

(2021) Xiangqin Meng et al.   ACS Nano

Blue light-triggered Fe2+-release from monodispersed ferrihydrite nanoparticles for cancer iron therapy

(2021) Yingchun Yang et al.   BIOMATERIALS

Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy

(2021) Jie Yang et al.   JOURNAL OF CONTROLLED RELEASE

Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells

(2021) Zhaoyuan Lyu et al.   Nano-Micro Letters

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

(2021) Yaofeng Zhou et al.   ADVANCED MATERIALS

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

(2020) Tian Xu et al.   ACS Nano

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

(2020) Jinchao Shen et al.   BIOMATERIALS

GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

(2020) Shuming Dong et al.   ADVANCED MATERIALS

Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer

(2020) Allison S. Cohen et al.   Translational Oncology

An Ultrahigh‐Field‐Tailored T 1 – T 2 Dual‐Mode MRI Contrast Agent for High‐Performance Vascular Imaging

(2020) Jin Wang et al.   ADVANCED MATERIALS

Hypoxia-Irrelevant Photonic Thermodynamic Cancer Nanomedicine

(2019) Huijing Xiang et al.   ACS Nano

Nanolongan with Multiple On-Demand Conversions for Ferroptosis–Apoptosis Combined Anticancer Therapy

(2019) Weier Bao et al.   ACS Nano

A Mn(III)-Sealed Metal-Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics

(2019) Shuang-Shuang Wan et al.   ACS Nano

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration

(2019) Mengxue Zhou et al.   NANO LETTERS

Molecular mechanisms of ferroptosis and its role in cancer therapy

(2019) Tao Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles

(2019) Jing Yu et al.   ACS Nano

A Tumor‐Microenvironment‐Activated Nanozyme‐Mediated Theranostic Nanoreactor for Imaging‐Guided Combined Tumor Therapy

(2019) Feng Liu et al.   ADVANCED MATERIALS

Fe–N–C Single-Atom Nanozymes for the Intracellular Hydrogen Peroxide Detection

(2019) Lei Jiao et al.   ANALYTICAL CHEMISTRY

Enhanced Tumor Synergistic Therapy by Injectable Magnetic Hydrogel Mediated Generation of Hyperthermia and Highly Toxic Reactive Oxygen Species

(2019) Haoan Wu et al.   ACS Nano

Mo2 C-Derived Polyoxometalate for NIR-II Photoacoustic Imaging-Guided Chemodynamic/Photothermal Synergistic Therapy

(2019) Gongyuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NIR-II Driven Plasmon-Enhanced Catalysis for a Timely Supply of Oxygen to Overcome Hypoxia-Induced Radiotherapy Tolerance

(2019) Yue Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer

(2019) Bin Liu et al.   BIOMATERIALS

Zn 2+ Doped Ultrasmall Prussian Blue Nanotheranostic Agent for Breast Cancer Photothermal Therapy under MR Imaging Guidance

(2019) Pingbo Shou et al.   Advanced Healthcare Materials

Localized Fe(II)-Induced Cytotoxic Reactive Oxygen Species Generating Nanosystem for Enhanced Anticancer Therapy

(2018) Yuxue Ding et al.   ACS Applied Materials & Interfaces

All-in-One Theranostic Nanoagent with Enhanced Reactive Oxygen Species Generation and Modulating Tumor Microenvironment Ability for Effective Tumor Eradication

(2018) Yang Liu et al.   ACS Nano

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

(2018) Max Piffoux et al.   ACS Nano

Nanozyme Decorated Metal–Organic Frameworks for Enhanced Photodynamic Therapy

(2018) Yan Zhang et al.   ACS Nano

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

(2018) Li-Sen Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells

(2018) Fanghui Sun et al.   BIOCHEMICAL PHARMACOLOGY

Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice

(2018) Gunnar Boysen et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy

(2018) Xiao Sun et al.   BIOMATERIALS

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

(2017) Ping’an Ma et al.   NANO LETTERS

Tumor Microenvironment-Enabled Nanotherapy

(2017) Liying Wang et al.   Advanced Healthcare Materials

Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation

(2016) Ming Xu et al.   ACS Nano

A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

(2016) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

(2015) Guangbao Yang et al.   BIOMATERIALS

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes

(2013) Hui Wei et al.   CHEMICAL SOCIETY REVIEWS

Dual Enzyme-like Activities of Iron Oxide Nanoparticles and Their Implication for Diminishing Cytotoxicity

(2012) Zhongwen Chen et al.   ACS Nano

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE