Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State

Interacting-heads motif explains the X-ray diffraction pattern of relaxed vertebrate skeletal muscle

(2022) Natalia A. Koubassova et al.   BIOPHYSICAL JOURNAL

To lie or not to lie: Super-relaxing with myosins

(2021) Suman Nag et al.   eLife

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

(2021) Manuel Schmid et al.   Biology Open

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle

(2021) Beatrice Scellini et al.   JOURNAL OF GENERAL PHYSIOLOGY

Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle

(2021) Jessica Bouviere et al.   Antioxidants

Structural basis of the super- and hyper-relaxed states of myosin II

(2021) Roger Craig et al.   JOURNAL OF GENERAL PHYSIOLOGY

The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways

(2021) Amr M. Abdelhamid et al.   Frontiers in Molecular Biosciences

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

(2020) Christopher N. Toepfer et al.   CIRCULATION

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Iacopo Olivotto et al.   LANCET

Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, disease, and mavacamten-treated cardiac systems

(2020) Sampath K. Gollapudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

(2019) Christopher N. Toepfer et al.   Science Translational Medicine

Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin

(2019) James W. McNamara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise induces muscle fiber type switching via transient receptor potential melastatin 2-dependent Ca2+ signaling

(2018) Seo-Ho Lee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

(2018) Kyoung Hwan Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle Contraction

(2018) H. Lee Sweeney et al.   Cold Spring Harbor Perspectives in Biology

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piperine, an alkaloid inhibiting the super-relaxed state of myosin, binds to the myosin regulatory light chain

(2018) Dmitri Tolkatchev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology

(2018) James W. McNamara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

(2017) Raja F. Kawas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

(2016) James A. Spudich et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Reply to Halanych et al.: Ctenophore misplacement is corroborated by independent datasets

(2016) Davide Pisani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

(2016) Leonardo Nogara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

Exercise Prevents Cardiac Injury and Improves Mitochondrial Biogenesis in Advanced Diabetic Cardiomyopathy with PGC-1α and Akt Activation

(2015) Hui Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

How Actin Initiates the Motor Activity of Myosin

(2015) Paola Llinas et al.   DEVELOPMENTAL CELL

Novel familial dilated cardiomyopathy mutation inMYL2affects the structure and function of myosin regulatory light chain

(2015) Wenrui Huang et al.   FEBS Journal

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis

(2015) Jianming Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise for the heart: signaling pathways

(2015) Lichan Tao et al.   Oncotarget

Electron microscopic recording of myosin head power stroke in hydrated myosin filaments

(2015) Haruo Sugi et al.   Scientific Reports

Diagnosis, prevalence, and screening of familial dilated cardiomyopathy

(2015) Mary E Sweet et al.   Expert Opinion on Orphan Drugs

Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process

(2013) Guidenn Sulbarán et al.   BIOPHYSICAL JOURNAL

Skeletal and cardiac α-actin isoforms differently modulate myosin cross-bridge formation and myofibre force production

(2013) Julien Ochala et al.   HUMAN MOLECULAR GENETICS

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

(2011) Reicy Brito et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Motion of myosin head domains during activation and force development in skeletal muscle

(2011) M. Reconditi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin Binding Protein C Interaction with Actin

(2010) Inna N. Rybakova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac stunning in the clinic: the full picture

(2009) Valdeci J. Pomblum et al.   Interactive Cardiovascular and Thoracic Surgery

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics

(2008) Michael J. Greenberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL