Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

(2011) Rusty L. Montgomery et al.   CIRCULATION

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Hypertrophic cardiomyopathy: from mutation to functional analysis of defective protein

(2011) Pavel Capek et al.   CROATIAN MEDICAL JOURNAL

A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy

(2011) Jodie Ingles et al.   HEART

Signaling to Myosin Regulatory Light Chain in Sarcomeres

(2011) Kristine E. Kamm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Myopathic Defects Engendered by Alterations in the Myosin Rod

(2011) Anthony Cammarato et al.   JOURNAL OF MOLECULAR BIOLOGY

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

The direct molecular effects of fatigue and myosin regulatory light chain phosphorylation on the actomyosin contractile apparatus

(2010) Michael J. Greenberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

(2010) P. Charron et al.   EUROPEAN HEART JOURNAL

DNA testing for hypertrophic cardiomyopathy: a cost-effectiveness model

(2010) S. Wordsworth et al.   EUROPEAN HEART JOURNAL

Common Structural Motifs for the Regulation of Divergent Class II Myosins

(2010) Susan Lowey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of contraction in mammalian striated muscles—the plotthick-ens: Figure 1.

(2010) Richard L. Moss et al.   JOURNAL OF GENERAL PHYSIOLOGY

A mutation in the β-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype

(2009) Thomas Z. Armel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardiomyopathy Mutations Reveal Variable Region of Myosin Converter as Major Element of Cross-Bridge Compliance

(2009) B. Seebohm et al.   BIOPHYSICAL JOURNAL

Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations

(2009) R. Walsh et al.   CARDIOLOGY

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

Removal of the cardiac myosin regulatory light chain increases isometric force production

(2009) Kiran Pant et al.   FASEB JOURNAL

Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline

(2009) Ray E. Hershberger et al.   JOURNAL OF CARDIAC FAILURE

Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis

(2009) Iacopo Olivotto et al.   Nature Reviews Cardiology

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sarcomere Mutations in Cardiogenesis and Ventricular Noncompaction

(2009) Elizabeth McNally et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex

(2008) Bradley M. Palmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hypertrophic Cardiomyopathy

(2008) Radhakrishnan Ramaraj   Cardiology in Review

MicroRNAs: novel regulators in cardiac development and disease

(2008) T. Thum et al.   CARDIOVASCULAR RESEARCH

Toward MicroRNA–Based Therapeutics for Heart Disease

(2008) Eva van Rooij et al.   CIRCULATION RESEARCH

Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone

(2008) Susan Lowey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics

(2008) Michael J. Greenberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

The Effects of Candesartan on Left Ventricular Hypertrophy and Function in Nonobstructive Hypertrophic Cardiomyopathy

(2008) Martin Penicka et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils

(2008) Alexandra Belus et al.   JOURNAL OF PHYSIOLOGY-LONDON

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics Assessment of β-Myosin Mutations Reveals Myosin's High Sensitivity to Mutations

(2008) Massimo Buvoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE