The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors
Authors
Keywords
-
Journal
NEUROPHARMACOLOGY
Volume 222, Issue -, Pages 109297
Publisher
Elsevier BV
Online
2022-11-02
DOI
10.1016/j.neuropharm.2022.109297
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inhibition of NMDA receptors through a membrane-to-channel path
- (2022) Madeleine R. Wilcox et al. Nature Communications
- Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors
- (2021) Marharyta Kolcheva et al. NEUROPHARMACOLOGY
- Reduced Expression of Hippocampal GluN2A-NMDAR Increases Seizure Susceptibility and Causes Deficits in Contextual Memory
- (2021) Maria Florencia Acutain et al. Frontiers in Neuroscience
- Structural basis of ketamine action on human NMDA receptors
- (2021) Youyi Zhang et al. NATURE
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
- (2021) Kasper B. Hansen et al. PHARMACOLOGICAL REVIEWS
- GRIN database: A unified and manually curated repertoire of GRIN variants
- (2020) Adrián García‐Recio et al. HUMAN MUTATION
- Dissecting diverse functions of NMDA receptors by structural biology
- (2019) Jue Xiang Wang et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors
- (2019) Feng Yi et al. JOURNAL OF PHYSIOLOGY-LONDON
- Lectins modulate the functional properties of GluN1/GluN3-containing NMDA receptors
- (2019) Katarina Hemelikova et al. NEUROPHARMACOLOGY
- Effects of Mg 2+ on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site
- (2018) Nathan G. Glasgow et al. NEUROPHARMACOLOGY
- Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties
- (2018) Laura Fedele et al. Nature Communications
- Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit
- (2018) Vojtech Vyklicky et al. Frontiers in Molecular Neuroscience
- Mechanism of NMDA receptor channel block by MK-801 and memantine
- (2018) Xianqiang Song et al. NATURE
- 7-Methoxyderivative of tacrine is a ‘foot-in-the-door’ open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo
- (2018) Martina Kaniakova et al. NEUROPHARMACOLOGY
- Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)
- (2018) Maurizio Fava et al. MOLECULAR PSYCHIATRY
- De novo GRIN1 mutations: An emerging cause of severe early infantile encephalopathy
- (2017) Yoav Zehavi et al. European Journal of Medical Genetics
- GRIN1 mutation associated with intellectual disability alters NMDA receptor trafficking and function
- (2017) Wenjuan Chen et al. JOURNAL OF HUMAN GENETICS
- Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
- (2017) Wei Lü et al. SCIENCE
- Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1
- (2017) Jamie McQueen et al. eLife
- GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers
- (2016) Dong Li et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Biochemical and electrophysiological characterization of N- glycans on NMDA receptor subunits
- (2016) Martina Kaniakova et al. JOURNAL OF NEUROCHEMISTRY
- Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives
- (2016) V. Vyklicky et al. JOURNAL OF NEUROSCIENCE
- Human GRIN2B variants in neurodevelopmental disorders
- (2016) Chun Hu et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Emerging roles of GluN3-containing NMDA receptors in the CNS
- (2016) Isabel Pérez-Otaño et al. NATURE REVIEWS NEUROSCIENCE
- Delineating the GRIN1 phenotypic spectrum
- (2016) Johannes R. Lemke et al. NEUROLOGY
- GRIN1mutations cause encephalopathy with infantile-onset epilepsy, and hyperkinetic and stereotyped movement disorders
- (2015) Chihiro Ohba et al. EPILEPSIA
- TwoN-glycosylation Sites in the GluN1 Subunit Are Essential for ReleasingN-methyl-d-aspartate (NMDA) Receptors from the Endoplasmic Reticulum
- (2015) Katarina Lichnerova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NMDA receptor structures reveal subunit arrangement and pore architecture
- (2014) Chia-Hsueh Lee et al. NATURE
- Crystal structure of a heterotetrameric NMDA receptor ion channel
- (2014) E. Karakas et al. SCIENCE
- GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine
- (2014) Tyler Mark Pierson et al. Annals of Clinical and Translational Neurology
- Triheteromeric NMDA Receptors at Hippocampal Synapses
- (2013) K. R. Tovar et al. JOURNAL OF NEUROSCIENCE
- NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
- (2013) Pierre Paoletti et al. NATURE REVIEWS NEUROSCIENCE
- Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery ofN-methyl-d-aspartate Receptors
- (2012) Martina Kaniakova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Probing the activation sequence of NMDA receptors with lurcher mutations
- (2012) Swetha E. Murthy et al. JOURNAL OF GENERAL PHYSIOLOGY
- Structural and thermodynamic analysis of the GFP:GFP-nanobody complex
- (2010) Marta H. Kubala et al. PROTEIN SCIENCE
- Different Roles of C-terminal Cassettes in the Trafficking of Full-length NR1 Subunits to the Cell Surface
- (2009) Martin Horak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine
- (2009) S. E. Kotermanski et al. JOURNAL OF NEUROSCIENCE
- Masking of the Endoplasmic Reticulum Retention Signals during Assembly of the NMDA Receptor
- (2008) M. Horak et al. JOURNAL OF NEUROSCIENCE
- The Activation Gate and Gating Mechanism of the NMDA Receptor
- (2008) H.-R. Chang et al. JOURNAL OF NEUROSCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation