Reduced Expression of Hippocampal GluN2A-NMDAR Increases Seizure Susceptibility and Causes Deficits in Contextual Memory

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity

(2020) Luca Franchini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Shifting from fear to safety through deconditioning-update

(2020) Bruno Popik et al.   eLife

Molecular Mechanisms in Hippocampus Involved on Object Recognition Memory Consolidation and Reconsolidation

(2020) Cristiane R.G. Furini et al.   NEUROSCIENCE

Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice

(2020) Ariadna Amador et al.   BRAIN

An Epilepsy-Associated GRIN2A Rare Variant Disrupts CaMKIIα Phosphorylation of GluN2A and NMDA Receptor Trafficking

(2020) Marta Mota Vieira et al.   Cell Reports

Validated animal models for antiseizure drug (ASD) discovery: Advantages and potential pitfalls in ASD screening

(2019) Melissa Barker-Haliski et al.   NEUROPHARMACOLOGY

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

(2019) Fanwei Zeng et al.   PLOS BIOLOGY

Neuropathological profile of the pentylenetetrazol (PTZ) kindling model

(2018) E. Samokhina et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets

(2018) Romain Cardis et al.   NEUROBIOLOGY OF DISEASE

NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus

(2018) Pradeep Punnakkal et al.   NEUROMOLECULAR MEDICINE

Interregional synaptic maps among engram cells underlie memory formation

(2018) Jun-Hyeok Choi et al.   SCIENCE

NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition

(2018) María Verónica Baez et al.   NEURAL PLASTICITY

GRIN2A-related disorders: genotype and functional consequence predict phenotype

(2018) Vincent Strehlow et al.   BRAIN

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats

(2018) Alaa Alachkar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional Properties of Human NMDA Receptors Associated with Epilepsy-Related Mutations of GluN2A Subunit

(2017) Dmitry A. Sibarov et al.   Frontiers in Cellular Neuroscience

Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency – molecular profiling and functional rescue

(2017) L. Addis et al.   Scientific Reports

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

(2016) Sharon A. Swanger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace

(2016) Roopashri Holehonnur et al.   JOURNAL OF NEUROSCIENCE

Consolidation and reconsolidation of object recognition memory

(2015) Israela Balderas et al.   BEHAVIOURAL BRAIN RESEARCH

Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory

(2015) Xiao-min Zhang et al.   CELL RESEARCH

NMDA receptor subunit mutations in neurodevelopmental disorders

(2015) Nail Burnashev et al.   CURRENT OPINION IN PHARMACOLOGY

Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs

(2015) Caroline Corbel et al.   Neural Development

Viral delivery of shRNA to amygdala neurons leads to neurotoxicity and deficits in Pavlovian fear conditioning

(2015) Christopher A. de Solis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

NMDA Receptor Function During Senescence: Implication on Cognitive Performance

(2015) Ashok Kumar   Frontiers in Neuroscience

Deletion of the NMDA Receptor GluN2A Subunit Significantly Decreases Dendritic Growth in Maturing Dentate Granule Neurons

(2014) Timal S. Kannangara et al.   PLoS One

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy

(2014) Hongjie Yuan et al.   Nature Communications

GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine

(2014) Tyler Mark Pierson et al.   Annals of Clinical and Translational Neurology

The Rodent Hippocampus Is Essential for Nonspatial Object Memory

(2013) Sarah J. Cohen et al.   CURRENT BIOLOGY

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

(2013) Johannes R Lemke et al.   NATURE GENETICS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Investigations into the involvement of NMDA mechanisms in recognition memory

(2013) E. Clea Warburton et al.   NEUROPHARMACOLOGY

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity

(2013) O. A. Shipton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression

(2013) Naoki Amada et al.   PeerJ

Multiple Roles of Annexin A2 in Post-Transcriptional Regulation of Gene Expressio

(2012) Anni Vedeler et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Protection Against Henipavirus Infection by Use of Recombinant Adeno-Associated Virus–Vector Vaccines

(2012) Aurélie Ploquin, Judit Szécsi, Cyrille Mathieu, Vanessa Guillaume, Véronique Barateau, Kien Chai Ong et al.   JOURNAL OF INFECTIOUS DISEASES

Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion

(2012) David M Bannerman et al.   NATURE NEUROSCIENCE

Diversity in NMDA Receptor Composition

(2012) Antonio Sanz-Clemente et al.   NEUROSCIENTIST

A cis-acting region in the N-methyl-d-aspartate R1 3′-untranslated region interacts with the novel RNA-binding proteins beta subunit of alpha glucosidase II and annexin A2 - effect of chronic ethanol exposure in vivo

(2011) Antje Anji et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes

(2011) C. Gao et al.   JOURNAL OF NEUROSCIENCE

Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo

(2011) John A. Gray et al.   NEURON

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear

(2011) Gemma L. Dalton et al.   NEUROPHARMACOLOGY

NMDA receptor subunit composition controls synaptogenesis and synapse stabilization

(2011) A. C. Gambrill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1

(2010) Fernando J. Sepulveda et al.   JOURNAL OF NEUROPHYSIOLOGY

Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes

(2010) Sabine Endele et al.   NATURE GENETICS

Fractionating spatial memory with glutamate receptor subunit-knockout mice: Figure 1

(2009) David M. Bannerman   BIOCHEMICAL SOCIETY TRANSACTIONS

Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation

(2009) Can Gao et al.   HIPPOCAMPUS

A revised Racine's scale for PTZ-induced seizures in rats

(2009) Annika Lüttjohann et al.   PHYSIOLOGY & BEHAVIOR

Hypoxia-Inducible Factor-1  Protects Cultured Cortical Neurons from Lipopolysaccharide-Induced Cell Death via Regulation of NR1 Expression

(2008) S.-H. Yeh et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory

(2008) D. M. Bannerman et al.   JOURNAL OF NEUROSCIENCE

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

(2008) Koji Yashiro et al.   NEUROPHARMACOLOGY