Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects

(2017) Konrad Platzer et al.   JOURNAL OF MEDICAL GENETICS

Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization

(2017) Nathan G. Glasgow et al.   JOURNAL OF NEUROSCIENCE

Structural modeling for the open state of an NMDA receptor

(2017) Xiaodong Pang et al.   JOURNAL OF STRUCTURAL BIOLOGY

Functions and dysfunctions of neocortical inhibitory neuron subtypes

(2017) Ryoma Hattori et al.   NATURE NEUROSCIENCE

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

(2016) Sharon A. Swanger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers

(2016) Dong Li et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors

(2016) Matthew Alsaloum et al.   JOURNAL OF NEUROSCIENCE

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder

(2016) Hongen Wei et al.   NEUROCHEMICAL RESEARCH

Pharmacology of triheteromeric N -Methyl- d -Aspartate Receptors

(2016) John Cheriyan et al.   NEUROSCIENCE LETTERS

Gene Expression Switching of Receptor Subunits in Human Brain Development

(2015) Ossnat Bar-Shira et al.   PLoS Computational Biology

TEMPy: a Python library for assessment of three-dimensional electron microscopy density fits

(2015) Irene Farabella et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane)

(2014) Gabriel Studer et al.   BIOINFORMATICS

Mg2+block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones

(2014) Zhuo Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular bases of NMDA receptor subtype-dependent properties

(2014) Nathan G. Glasgow et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Structural Insights into Competitive Antagonism in NMDA Receptors

(2014) Annie Jespersen et al.   NEURON

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine

(2014) Tyler Mark Pierson et al.   Annals of Clinical and Translational Neurology

GRIN2Bmutations in west syndrome and intellectual disability with focal epilepsy

(2013) Johannes R. Lemke et al.   ANNALS OF NEUROLOGY

De novo mutations in epileptic encephalopathies

(2013) et al.   NATURE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Key Binding Interactions for Memantine in the NMDA Receptor

(2012) Walrati Limapichat et al.   ACS Chemical Neuroscience

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

(2012) S. Edman et al.   NEUROPHARMACOLOGY

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging

(2011) Siba R. Das et al.   BEHAVIOURAL BRAIN RESEARCH

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

(2011) S McKay et al.   BRITISH JOURNAL OF PHARMACOLOGY

The NMDA receptor complex as a therapeutic target in epilepsy: a review

(2011) Mehdi Ghasemi et al.   EPILEPSY & BEHAVIOR

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Memantine binding to a superficial site on NMDA receptors contributes to partial trapping

(2009) Shawn E. Kotermanski et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-dependent gating of NR1/2B NMDA receptors

(2008) Richard J. Clarke et al.   JOURNAL OF PHYSIOLOGY-LONDON