Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea

(2022) Maohua Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage

(2022) Yuhua Zhang et al.   Autophagy

Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss

(2022) Xiaolong Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation

(2021) Yongpeng Zou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway

(2021) Lian Liu et al.   FASEB JOURNAL

Catalpol alleviates myocardial ischemia reperfusion injury by activating the Nrf2/HO-1 signaling pathway

(2021) Hanwei Ge et al.   MICROVASCULAR RESEARCH

The Atoh1 expression levels are correlated with the arrangement, ciliary morphology, and electrophysiological characteristics of ectopic hair cell-like cells

(2020) Yu Zheng et al.   NEUROSCIENCE LETTERS

Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity

(2020) Zhiwei Zheng et al.   Oxidative Medicine and Cellular Longevity

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes

(2019) Zhen Qiu et al.   Journal of Diabetes Research

Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear

(2019) Masaya Takumida et al.   ACTA OTO-LARYNGOLOGICA

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis

(2019) Pengpeng An et al.   LIFE SCIENCES

Clinical Practice Guideline: Sudden Hearing Loss (Update) Executive Summary

(2019) Sujana S. Chandrasekhar et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

(2019) Xuebin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats

(2019) Yan She et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resveratrol increase myocardial Nrf2 expression in type 2 diabetic rats and alleviate myocardial ischemia/reperfusion injury (MIRI)

(2019) Guiping Xu et al.   Annals of Palliative Medicine

Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation

(2019) Lili Liu et al.   LIFE SCIENCES

Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia–Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models

(2019) Daohang Liu et al.   NEUROCHEMICAL RESEARCH

Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells

(2018) Hyemin Lee et al.   JOURNAL OF PINEAL RESEARCH

Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats

(2018) Zhong-Yan Miao et al.   NEUROLOGICAL RESEARCH

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2 /Akt/NF-κB pathway

(2017) Xaykham Onphachanh et al.   JOURNAL OF PINEAL RESEARCH

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Melatonin protects inner ear against radiation damage in rats

(2015) Isil Karaer et al.   LARYNGOSCOPE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Clinical Practice Guideline

(2012) Robert J. Stachler et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY