Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology

(2021) Wejdane El Manaa et al.   Autophagy

Outcomes of Peptide Vaccine GV1001 Treatment in a Murine Model of Acute Noise-Induced Hearing Loss

(2020) Sang-Yeon Lee et al.   Antioxidants

Transduction of Adeno-Associated Virus Vectors Targeting Hair Cells and Supporting Cells in the Neonatal Mouse Cochlea

(2019) Xi Gu et al.   Frontiers in Cellular Neuroscience

The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson’s Disease

(2019) Wei Yi et al.   HUMAN MOLECULAR GENETICS

Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells

(2019) Zeng-li Zhang et al.   ACTA PHARMACOLOGICA SINICA

The plant hormone kinetin in disease therapy and healthy aging

(2019) Alena Kadlecová et al.   AGEING RESEARCH REVIEWS

AAV-ie enables safe and efficient gene transfer to inner ear cells

(2019) Fangzhi Tan et al.   Nature Communications

ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis

(2018) Marta Bueno et al.   AGING CELL

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

(2018) Thomas Goiran et al.   BIOLOGICAL PSYCHIATRY

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

(2018) Thomas Goiran et al.   CELL DEATH AND DIFFERENTIATION

Dual role of USP30 in controlling basal pexophagy and mitophagy

(2018) Elena Marcassa et al.   EMBO REPORTS

Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats

(2018) Pouran Makhdoumi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies

(2018) Corné J. Kros et al.   Cold Spring Harbor Perspectives in Medicine

PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway

(2018) Qianqian Yang et al.   Frontiers in Molecular Neuroscience

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

(2017) Lukas D Landegger et al.   NATURE BIOTECHNOLOGY

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

(2017) Matthew Y. Tang et al.   Nature Communications

c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro

(2017) Xiaoyu Yu et al.   Scientific Reports

Erratum

(2016)   Autophagy

Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond

(2016) Baris Bingol et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro

(2016) Ming Guan et al.   Oncotarget

Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro

(2016) Zuhong He et al.   Scientific Reports

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria

(2015) Yvette C Wong et al.   Autophagy

Folliculin, a tumor suppressor associated with Birt–Hogg–Dubé (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation

(2015) Qin Xia et al.   HUMAN MOLECULAR GENETICS

Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity

(2015) Zhouteng Tao et al.   HUMAN MOLECULAR GENETICS

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Mechanisms of sensorineural cell damage, death and survival in the cochlea

(2015) Ann C. Y. Wong et al.   Frontiers in Aging Neuroscience

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Perspectives of drug-based neuroprotection targeting mitochondria

(2014) V. Procaccio et al.   REVUE NEUROLOGIQUE

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Does the Environment Affect the Absorption Spectrum of the Fluorescent Protein mKeima?

(2013) Marc Nadal-Ferret et al.   Journal of Chemical Theory and Computation

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult

(2013) Yan Chen et al.   Scientific Reports

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin-induced mitophagy in the pathogenesis of Parkinson disease

(2009) Derek Narendra et al.   Autophagy

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation

(2009) Zheng Ying et al.   HUMAN MOLECULAR GENETICS

Excited State Proton Transfer in the Red Fluorescent Protein mKeima

(2009) J. Nathan Henderson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells

(2008) Bo-Hwa Choi et al.   CANCER LETTERS

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Fluorescence imaging using a fluorescent protein with a large Stokes shift

(2008) Takako Kogure et al.   METHODS

Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice

(2008) Jian Wang et al.   NEUROBIOLOGY OF AGING

Aminoglycoside induced ototoxicity

(2008) O’neil W. Guthrie   TOXICOLOGY