Enhancement of high glucose-induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT2 /Akt/NF-κB pathway

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

(2016) Tiinamaija Tuomi et al.   Cell Metabolism

Inducing mitophagy in diabetic platelets protects against severe oxidative stress

(2016) Seung Hee Lee et al.   EMBO Molecular Medicine

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

(2016) María E. Díaz-Casado et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells

(2016) Premranjan Kumar et al.   MOLECULAR NEUROBIOLOGY

ClC-3 Expression and Its Association with Hyperglycemia Induced HT22 Hippocampal Neuronal Cell Apoptosis

(2016) Feiyan Fan et al.   Journal of Diabetes Research

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

(2016) Hyun Jik Lee et al.   Scientific Reports

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

Melatonin enhances the occurrence of autophagy induced by oxidative stress inArabidopsisseedlings

(2015) Ping Wang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Activation of Melatonin Signaling Promotes β-Cell Survival and Function

(2015) Safia Costes et al.   MOLECULAR ENDOCRINOLOGY

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

(2015) Hitoshi Murata et al.   PLoS One

The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy

(2014) Scott A. Soleimanpour et al.   CELL

The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling

(2014) D Liu et al.   CELL DEATH AND DIFFERENTIATION

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Advanced glycation end products induce oxidative stress and mitochondrial dysfunction in SH-SY5Y cells

(2014) Xu Wang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Role of Glucose Metabolism and ATP in Maintaining PINK1 Levels during Parkin-mediated Mitochondrial Damage Responses

(2014) Schuyler Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of neurons from high glucose-induced injury by deletion of MAD2B

(2014) Xianfang Meng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress and Inflammation in Diabetic Complications

(2014) Ajit Vikram et al.   International Journal of Endocrinology

Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy

(2014) Ying Tang et al.   Journal of Diabetes Investigation

Upregulation of human PINK1 gene expression by NFκB signalling

(2014) Xiaoling Duan et al.   Molecular Brain

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Melatonin Secretion and the Incidence of Type 2 Diabetes

(2013) Ciaran J. McMullan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress

(2013) Nicoleta Moisoi et al.   NEUROPHARMACOLOGY

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

(2013) K. Baba et al.   Science Signaling

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

(2013) Karl Grenier et al.   Frontiers in Neurology

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Type 1 diabetes mellitus in mice increases hippocampal d-serine in the acute phase after streptozotocin injection

(2012) Masataka Suzuki et al.   BRAIN RESEARCH

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Role of melatonin in the regulation of autophagy and mitophagy: A review

(2012) Ana Coto-Montes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A competing risk approach for the European Heart SCORE model based on cause-specific and all-cause mortality

(2012) Henrik Støvring et al.   European Journal of Preventive Cardiology

Regulation of Autophagy by Glucose in Mammalian Cells

(2012) Félix Moruno et al.   Cells

Encephalopathies: the emerging diabetic complications

(2010) Anders A. F. Sima   ACTA DIABETOLOGICA

Glycoxidative stress-induced mitophagy modulates mitochondrial fates

(2010) Mei-Chen Lo et al.   Annals of the New York Academy of Sciences

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Melatonin signaling and cell protection function

(2010) Francesca Luchetti et al.   FASEB JOURNAL

Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

(2010) Pil-Jae Kong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Intracellular Prooxidant Activity of Melatonin Induces a Survival Pathway Involving NF-κB Activation

(2009) Silvia Cristofanon et al.   Annals of the New York Academy of Sciences

Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation

(2009) Mahdieh Sadidi et al.   BIOCHIMIE

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

(2008) R Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

(2008) O. Anichtchik et al.   JOURNAL OF NEUROSCIENCE

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

(2008) Alison Wood-Kaczmar et al.   PLoS One

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

(2008) Harald Staiger et al.   PLoS One