Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss

mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia

(2019) Lena H. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR

(2019) Bin Ye et al.   Autophagy

Sirolimus monotherapy for Erdheim–Chester disease

(2019) Eric F. H. van Bommel et al.   ACTA ONCOLOGICA

Mechanistic target of rapamycin (mTOR) signaling in status epilepticus

(2019) Peter B. Crino   EPILEPSY & BEHAVIOR

GSTA4 mediates reduction of cisplatin ototoxicity in female mice

(2019) Hyo-Jin Park et al.   Nature Communications

Tuberous sclerosis complex–associated CNS abnormalities depend on hyperactivation of mTORC1 and Akt

(2018) Paola Zordan et al.   JOURNAL OF CLINICAL INVESTIGATION

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

(2018) Tal Teitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

(2018) Ping Jun Zhu et al.   NATURE NEUROSCIENCE

Effects of rapamycin on growth hormone receptor knockout mice

(2018) Yimin Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development

(2018) Xuguang Nie et al.   PLoS Genetics

Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea

(2018) R.A. Altschuler et al.   HEARING RESEARCH

Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss

(2018) Xiaolong Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

(2017) David R Freyer et al.   LANCET ONCOLOGY

Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress

(2017) Daniel Bodmer et al.   Cell Death & Disease

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

(2017) R. W. Hallowell et al.   Nature Communications

Combined Targeting of mTOR and Akt Using Rapamycin and MK-2206 in The Treatment of Tuberous Sclerosis Complex

(2017) Shuang Ji et al.   Journal of Cancer

Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy

(2016) Nesrine Benkafadar et al.   EMBO Molecular Medicine

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

(2016) Xiaolei Ding et al.   Nature Communications

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

(2015) Sebastiano Sciarretta et al.   Cell Reports

Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite FormationIn Vitro

(2015) Katharina Leitmeyer et al.   Biomed Research International

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage

(2013) Mirko Völkers et al.   CIRCULATION

Bax, Bcl2, and p53 Differentially Regulate Neomycin- and Gentamicin-Induced Hair Cell Death in the Zebrafish Lateral Line

(2013) Allison B. Coffin et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

AKT2 is essential to maintain podocyte viability and function during chronic kidney disease

(2013) Guillaume Canaud et al.   NATURE MEDICINE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development

(2013) Hyung Jin Kim et al.   PLoS One

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

(2011) Seth A. Wander et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

Quo vadis, hair cell regeneration?

(2009) John V Brigande et al.   NATURE NEUROSCIENCE

Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity

(2009) Daniela Cota   PHYSIOLOGY & BEHAVIOR

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE