Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation
Published 2023 View Full Article
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Title
Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation
Authors
Keywords
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Journal
MOLECULAR CELL
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2023-01-23
DOI
10.1016/j.molcel.2022.12.033
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Note: Only part of the references are listed.- The properties of human disease mutations at protein interfaces
- (2022) Benjamin J. Livesey et al. PLoS Computational Biology
- ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
- (2021) Dejie Wang et al. Science Advances
- Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation
- (2021) Jesse M Hansen et al. eLife
- The emerging role of SPOP protein in tumorigenesis and cancer therapy
- (2020) Yizuo Song et al. Molecular Cancer
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- NEDD8 and ubiquitin ligation by cullin-RING E3 ligases
- (2020) Kheewoong Baek et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants
- (2019) Michael Sebastian Ostertag et al. JOURNAL OF MOLECULAR BIOLOGY
- The ubiquitin ligase adaptor SPOP in cancer
- (2019) Matthew J. Cuneo et al. FEBS Journal
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
- (2019) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators
- (2018) Dorothy C. C. Wai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
- (2018) Jill J. Bouchard et al. MOLECULAR CELL
- TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
- (2017) Bin Wang et al. NATURE
- Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
- (2017) Xiangpeng Dai et al. NATURE MEDICINE
- Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
- (2017) Pingzhao Zhang et al. NATURE MEDICINE
- Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
- (2017) Hana Janouskova et al. NATURE MEDICINE
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
- (2017) C Geng et al. ONCOGENE
- Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation
- (2016) Daniel C. Scott et al. CELL
- Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles
- (2016) Melissa R Marzahn et al. EMBO JOURNAL
- Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination
- (2016) Wendy K. Pierce et al. JOURNAL OF MOLECULAR BIOLOGY
- Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
- (2014) C. Geng et al. CANCER RESEARCH
- Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8
- (2014) Daniel C. Scott et al. CELL
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
- (2014) J.-P. P. Theurillat et al. SCIENCE
- Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
- (2014) Jian An et al. Cell Reports
- Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP
- (2013) Laura K. van Geersdaele et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome
- (2013) Teresa Davoli et al. CELL
- Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
- (2013) C. Geng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- (2012) Matthieu Le Gallo et al. NATURE GENETICS
- Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
- (2012) Christopher E Barbieri et al. NATURE GENETICS
- Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase
- (2012) Wesley J. Errington et al. STRUCTURE
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1
- (2010) Evan Small et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
- (2009) Min Zhuang et al. MOLECULAR CELL
- Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
- (2009) Qing Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
- (2008) David M. Duda et al. CELL
- Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2
- (2008) Danny T Huang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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