ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants

(2019) Michael Sebastian Ostertag et al.   JOURNAL OF MOLECULAR BIOLOGY

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

Whole-genome and Transcriptome Sequencing of Prostate Cancer Identify New Genetic Alterations Driving Disease Progression

(2018) Shancheng Ren et al.   EUROPEAN UROLOGY

The long tail of oncogenic drivers in prostate cancer

(2018) Joshua Armenia et al.   NATURE GENETICS

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

(2018) Maria Victoria Botuyan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein

(2018) Maria Victoria Botuyan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

(2018) Jill J. Bouchard et al.   MOLECULAR CELL

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

(2018) Jonas Andreas Schmid et al.   MOLECULAR CELL

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability

(2018) Kim Hjorth-Jensen et al.   NUCLEIC ACIDS RESEARCH

The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation

(2018) Michael Sebastian Ostertag et al.   STRUCTURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

(2017) Pascal Drané et al.   NATURE

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

(2017) Pingzhao Zhang et al.   NATURE MEDICINE

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks

(2017) Ignacio Torrecilla et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

(2017) Stefania Pellegrino et al.   Cell Reports

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination

(2016) Wendy K. Pierce et al.   JOURNAL OF MOLECULAR BIOLOGY

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

(2016) Raquel Cuella-Martin et al.   MOLECULAR CELL

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

(2015) Martin A. Michel et al.   MOLECULAR CELL

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

(2015) Joaquin Mateo et al.   NEW ENGLAND JOURNAL OF MEDICINE

CSI 3.0: a web server for identifying secondary and super-secondary structure in proteins using NMR chemical shifts

(2015) Noor E. Hafsa et al.   NUCLEIC ACIDS RESEARCH

SPOP mutation leads to genomic instability in prostate cancer

(2015) Gunther Boysen et al.   eLife

Speckle-type POZ protein, SPOP, is involved in the DNA damage response

(2014) D. Zhang et al.   CARCINOGENESIS

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

(2014) Jian An et al.   Cell Reports

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

(2013) K.-Y. Hsiao et al.   Journal of Molecular Cell Biology

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

The Histone Methyltransferase MMSET Regulates Class Switch Recombination

(2012) H. Pei et al.   JOURNAL OF IMMUNOLOGY

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1

(2012) N. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks

(2011) Mayura Meerang et al.   NATURE CELL BIOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE