SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

(2016) Anna C. Groner et al.   CANCER CELL

Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer

(2016) Xiaofei Zhi et al.   Cell Death & Disease

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

(2015) Gretchen K. Hubbard et al.   CANCER RESEARCH

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity

(2015) Zhichao Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorectal Cancer

(2015) Junfei Xu et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

(2015) Jian An et al.   MOLECULAR CELL

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

(2015) Wenjian Gan et al.   MOLECULAR CELL

Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival

(2015) L Fan et al.   ONCOGENE

Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer

(2015) C Coarfa et al.   ONCOGENE

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

(2015) Stefan J. Barfeld et al.   Oncotarget

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

(2015) Hengrui Zhu et al.   Cell Reports

SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

(2015) Mirjam Blattner et al.   NEOPLASIA

AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

(2014) C. Priolo et al.   CANCER RESEARCH

Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer

(2014) C. Geng et al.   CANCER RESEARCH

Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer

(2014) María García-Flores et al.   EUROPEAN JOURNAL OF CANCER

Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants

(2014) Pingzhao Zhang et al.   HUMAN MUTATION

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer

(2014) Chunyan Zeng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

(2014) Bin He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

(2014) Jian An et al.   Cell Reports

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

8q24 amplification is associated with Myc expression and prostate cancer progression and is an independent predictor of recurrence after radical prostatectomy

(2013) Gaelle Fromont et al.   HUMAN PATHOLOGY

Tracking the clonal origin of lethal prostate cancer

(2013) Michael C. Haffner et al.   JOURNAL OF CLINICAL INVESTIGATION

ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc

(2013) C Zhang et al.   ONCOGENE

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Levels of H3K27me3 Track with Differentiation in Vivo and Are Deregulated by MYC in Prostate Cancer

(2012) Laxmi G. Pellakuru et al.   AMERICAN JOURNAL OF PATHOLOGY

Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation

(2012) Nahyun Choi et al.   CANCER CELL

Novel Oncogene-Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression Signatures

(2012) X. Ju et al.   CANCER RESEARCH

The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping

(2012) Steve D. M. Brown et al.   MAMMALIAN GENOME

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

USP2a Activation of MYC in Prostate Cancer

(2012) William G. Nelson et al.   Cancer Discovery

Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene

(2011) Cheryl M. Koh et al.   AMERICAN JOURNAL OF PATHOLOGY

The genomic complexity of primary human prostate cancer

(2011) Michael F. Berger et al.   NATURE

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

(2010) Kathryn C. Claiborn et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

(2010) Tsuyoshi Iwata et al.   PLoS One

8q24 allelic imbalance and MYC gene copy number in primary prostate cancer

(2010) H Chen et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Evaluation of the 8q24 Prostate Cancer Risk Locus and MYC Expression

(2009) Mark M. Pomerantz et al.   CANCER RESEARCH

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY

TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation

(2008) C Sun et al.   ONCOGENE