The ubiquitin ligase adaptor SPOP in cancer

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer

(2019) Xin Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions

(2018) Thuy P. Dao et al.   MOLECULAR CELL

SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

(2018) Lin-Gao Ju et al.   CELL DEATH AND DIFFERENTIATION

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

(2018) Jill J. Bouchard et al.   MOLECULAR CELL

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression

(2018) Jinfang Zhang et al.   DEVELOPMENTAL CELL

The Pfam protein families database in 2019

(2018) Sara El-Gebali et al.   NUCLEIC ACIDS RESEARCH

The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation

(2018) Michael Sebastian Ostertag et al.   STRUCTURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

(2017) Xiangpeng Dai et al.   NATURE MEDICINE

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

(2017) Pingzhao Zhang et al.   NATURE MEDICINE

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

(2017) Hana Janouskova et al.   NATURE MEDICINE

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein

(2017) C Geng et al.   ONCOGENE

Targeted protein degradation by PROTACs

(2017) Taavi K. Neklesa et al.   PHARMACOLOGY & THERAPEUTICS

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

(2017) Xiaofeng Jin et al.   PLoS Genetics

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

(2016) Anna C. Groner et al.   CANCER CELL

Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer

(2016) Zhong-Qiang Guo et al.   CANCER CELL

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination

(2016) Wendy K. Pierce et al.   JOURNAL OF MOLECULAR BIOLOGY

SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing

(2016) Kun Zhu et al.   NUCLEIC ACIDS RESEARCH

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer

(2015) Shanshan Duan et al.   MOLECULAR CELL

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

(2015) Jian An et al.   MOLECULAR CELL

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

(2015) Wenjian Gan et al.   MOLECULAR CELL

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

(2015) P Zhang et al.   Cell Death & Disease

SPOP mutation leads to genomic instability in prostate cancer

(2015) Gunther Boysen et al.   eLife

SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

(2014) Guoqiang Li et al.   CANCER CELL

Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer

(2014) C. Geng et al.   CANCER RESEARCH

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

(2014) Jian An et al.   Cell Reports

Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP

(2013) Laura K. van Geersdaele et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Androgen Receptor Antagonists in Castration-Resistant Prostate Cancer

(2013) Dana Rathkopf et al.   CANCER JOURNAL

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

(2012) Matthieu Le Gallo et al.   NATURE GENETICS

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

(2012) Wesley J. Errington et al.   STRUCTURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3–SPOP E3 ubiquitin ligase complex

(2011) Bogyou Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

Structural assembly of cullin-RING ubiquitin ligase complexes

(2010) Erik S Zimmerman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

(2010) Kathryn C. Claiborn et al.   JOURNAL OF CLINICAL INVESTIGATION

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer

(2009) J. Liu et al.   SCIENCE