A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

Incidence of Peri-Implantitis and Relationship with Different Conditions: A Retrospective Study

(2022) Víctor Astolfi et al.   International Journal of Environmental Research and Public Health

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

(2022) Jing Li et al.   Frontiers in Pharmacology

Biomarker levels in peri‐implant crevicular fluid of healthy implants, untreated and non‐surgically treated implants with peri‐implantitis

(2021) Diederik F.M. Hentenaar et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Specific inhibition of IL‐6 receptor attenuates inflammatory bone loss in experimental periodontitis

(2021) Gustavo H. Apolinário Vieira et al.   JOURNAL OF PERIODONTOLOGY

Characterization and Function of Tumor Necrosis Factor alpha and Interleukin‐6‐Induced Osteoclasts in Rheumatoid Arthritis

(2021) Kazuhiro Yokota et al.   Arthritis & Rheumatology

The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

(2021) Sipin Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of a rat model for type 2 diabetes mellitus peri‐implantitis: A preliminary study

(2021) Qingqing He et al.   ORAL DISEASES

Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production

(2021) Shino Matsukawa et al.   PLoS One

Melatonin prevents peri‑implantitis via suppression of TLR4/NF-κB

(2021) Xiangbing Wu et al.   Acta Biomaterialia

PD-L1 Regulates Inflammation in LPS-Induced Lung Epithelial Cells and Vascular Endothelial Cells by Interacting with the HIF-1α Signaling Pathway

(2021) Shilong Zhao et al.   INFLAMMATION

Surgical treatment of peri‐implantitis with or without a deproteinized bovine bone mineral and a native bilayer collagen membrane: A randomized clinical trial

(2021) Stefan Renvert et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Pro‐inflammatory profiles in cardiovascular disease patients with peri‐implantitis

(2021) I‐Ching Wang et al.   JOURNAL OF PERIODONTOLOGY

The management of diabetes mellitus by mangiferin: advances and prospects

(2021) Mengdi Wang et al.   Nanoscale

The effect of conventional versus electronic cigarette use on treatment outcomes of peri-implant disease

(2021) Reham AlJasser et al.   BMC Oral Health

Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production

(2020) Hozaifa Metwally et al.   Science Signaling

Microbial Community-Driven Etiopathogenesis of Peri-Implantitis

(2020) G.N. Belibasakis et al.   JOURNAL OF DENTAL RESEARCH

Combination of LMT-28 and Metformin Improves Beneficial Anti-Inflammatory Effect in Collagen-Induced Arthritis

(2020) Yeon-Hwa Park et al.   PHARMACOLOGY

Mechanisms of RANKL delivery to the osteoclast precursor cell surface

(2020) Masashi Honma et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Anti‐interleukin‐6 therapy decreases hip synovitis and bone resorption and increases bone formation following ischemic osteonecrosis of the femoral head

(2020) Yinshi Ren et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging

(2020) Juliet Akkaoui et al.   GeroScience

A directly GP130‐targeting small molecule ameliorates collagen‐induced arthritis (CIA) by inhibiting IL‐6/GP130 signaling and Th17 differentiation

(2019) Yeon‐Hwa Park et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Development of a peri‐implantitis model in the rat

(2019) Jingqing Sun et al.   CLINICAL ORAL IMPLANTS RESEARCH

6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts

(2019) Nonaka et al.   MOLECULES

Combination of gp130-targeting and TNF-targeting small molecules in alleviating arthritis through the down-regulation of Th17 differentiation and osteoclastogenesis

(2019) Yeon-Hwa Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

(2018) William M. Armstead et al.   Translational Stroke Research

Obesity causes Pgc-1α deficiency in the pancreas leading to marked Il-6 up-regulation via NF-κB in acute pancreatitis

(2018) Salvador Pérez et al.   JOURNAL OF PATHOLOGY

Use of IL-1 β, IL-6, TNF-α, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis

(2018) Iya Ghassib et al.   Clinical Implant Dentistry and Related Research

Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs

(2018) Victor Curvello et al.   Neurocritical Care

Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis

(2017) Alberto Monje et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Daidzein increases OPG/RANKL ratio and suppresses IL-6 in MG-63 osteoblast cells

(2016) Jing Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

AGEs-Induced IL-6 Synthesis Precedes RAGE Up-Regulation in HEK 293 Cells: An Alternative Inflammatory Mechanism?

(2015) Andreea Serban et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor β Subunit, Glycoprotein 130

(2015) Soon-Sun Hong et al.   JOURNAL OF IMMUNOLOGY

Glycated matrix up-regulates inflammatory signaling similarly toPorphyromonas gingivalislipopolysaccharide

(2012) P-C. Chang et al.   JOURNAL OF PERIODONTAL RESEARCH

NF-κB modulators in osteolytic bone diseases

(2008) Jiake Xu et al.   CYTOKINE & GROWTH FACTOR REVIEWS