The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

CC chemokine receptor 2 functions in osteoblastic transformation of valvular interstitial cells

(2019) Enyi Zhu et al.   LIFE SCIENCES

Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis

(2019) Bridie S. Mulholland et al.   Current Osteoporosis Reports

Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1

(2018) Liying Shi et al.   CELL TRANSPLANTATION

Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow–derived macrophages

(2018) Lilli Arndt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear factor kappa B regulated monocyte chemoattractant protein-1/chemokine CC motif receptor-2 expressing in spinal cord contributes to the maintenance of cancer-induced bone pain in rats

(2018) Yungong Wang et al.   Molecular Pain

Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell

(2018) Xiao-Bo Wu et al.   NEUROPSYCHOPHARMACOLOGY

CCR2 Signal Facilitates Thymic Egress by Priming Thymocyte Responses to Sphingosine-1-Phosphate

(2018) Abudureyimujiang Aili et al.   Frontiers in Immunology

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

(2018) Amit Kumar Rana et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells

(2017) Eszter Bakos et al.   JOURNAL OF IMMUNOLOGY

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

(2017) J. Miotla Zarebska et al.   OSTEOARTHRITIS AND CARTILAGE

CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone

(2017) Jawed Akhtar Siddiqui et al.   Frontiers in Endocrinology

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

(2017) Ilze Bot et al.   Scientific Reports

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of CXCL2 and CCL2 by pressure force requires IL-1β-MyD88 axis in osteoblasts

(2015) Aya Maeda et al.   BONE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4

(2015) Rachel E. Miller et al.   Arthritis & Rheumatology

Reduction in Disease Progression by Inhibition of Transforming Growth Factor α-CCL2 Signaling in Experimental Posttraumatic Osteoarthritis

(2015) C. Thomas G. Appleton et al.   Arthritis & Rheumatology

Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis

(2015) Liang Li et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease

(2015) Mohammed Akli Ayoub et al.   PLoS One

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

PKC–NF-κB are involved in CCL2-induced Nav1.8 expression and channel function in dorsal root ganglion neurons

(2014) Rui Zhao et al.   BIOSCIENCE REPORTS

CCR2 Elimination in Mice Results in Larger and Stronger Tibial Bones but Bone Loss is not Attenuated Following Ovariectomy or Muscle Denervation

(2014) Tara L. Mader et al.   CALCIFIED TISSUE INTERNATIONAL

Serum Monocyte Chemokine Protein-1 Levels Before and After Parathyroidectomy in Patients with Primary Hyperparathyroidism

(2014) Hemal Patel et al.   Endocrine Practice

Human Cytomegalovirus Latent Infection of Myeloid Cells Directs Monocyte Migration by Up-Regulating Monocyte Chemotactic Protein-1

(2014) J. L. Stern et al.   JOURNAL OF IMMUNOLOGY

CCR2 Deficiency Impairs Macrophage Infiltration and Improves Cognitive Function after Traumatic Brain Injury

(2014) Christine L. Hsieh et al.   JOURNAL OF NEUROTRAUMA

Bindarit, an Inhibitor of Monocyte Chemotactic Protein Synthesis, Protects against Bone Loss Induced by Chikungunya Virus Infection

(2014) Weiqiang Chen et al.   JOURNAL OF VIROLOGY

Indole-3-Carbinol and 3',3'-Diindolylmethane Modulate Androgen's Effect on C-C Chemokine Ligand 2 and Monocyte Attraction to Prostate Cancer Cells

(2013) E.-K. Kim et al.   Cancer Prevention Research

Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds

(2013) K. Migita et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1)

(2013) Joshua H. Y. Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone

(2013) Joseph A Tamasi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PTHrP Produced by Myeloma Plasma Cells Regulates Their Survival and Pro-Osteoclast Activity For Bone Disease Progression

(2013) Paola Cafforio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles

(2013) V.S. De Paula et al.   JOURNAL OF MOLECULAR BIOLOGY

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Hyperocclusion Up-regulates CCL3 Expression in CCL2- and CCR2-deficient Mice

(2012) T. Tsutsumi et al.   JOURNAL OF DENTAL RESEARCH

Naringin inhibits chemokine production in an LPS-induced RAW 264.7 macrophage cell line

(2012) YING LIU et al.   Molecular Medicine Reports

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

MCP-1 and CCR2 Gene Variants and the Risk for Osteoporosis and Osteopenia

(2011) Hakan Eraltan et al.   Genetic Testing and Molecular Biomarkers

Absence of MCP-1 leads to elevated bone mass via impaired actin ring formation

(2011) Ok-Joo Sul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential effect of CCL2 on constitutive neutrophil apoptosis between normal and asthmatic subjects

(2011) Eun Ju Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The High Serum Monocyte Chemoattractant Protein-1 in Obesity Is Influenced by High Parathyroid Hormone and Not Adiposity

(2011) D. Sukumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Chemokine CCL2 Increases Nav1.8 Sodium Channel Activity in Primary Sensory Neurons through a G  -Dependent Mechanism

(2011) M. Belkouch et al.   JOURNAL OF NEUROSCIENCE

Therapeutic effect of a topical CCR2 antagonist on induced alveolar bone loss in mice

(2011) S. P. Barros et al.   JOURNAL OF PERIODONTAL RESEARCH

IL-17-Mediated Monocyte Migration Occurs Partially through CC Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Induction

(2010) S. Shahrara et al.   JOURNAL OF IMMUNOLOGY

Multiple Roles of Chemokine (C-C Motif) Ligand 2 in Promoting Prostate Cancer Growth

(2010) J. Zhang et al.   JNCI-Journal of the National Cancer Institute

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis

(2009) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

(2009) Kana Miyamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone

(2009) Xin Li et al.   CANCER RESEARCH

Recent developments in CCR2 antagonists

(2009) Mingde Xia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis

(2009) Nikolaus B Binder et al.   NATURE MEDICINE

n-Nonanoyl-CCL14 (NNY-CCL14), a novel inhibitor of allergic airway inflammation is a partial agonist of human CCR2

(2008) S. Gupta et al.   ALLERGY

Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial

(2008) Clarissa E. Vergunst et al.   ARTHRITIS AND RHEUMATISM

Gene expression profile of the bone microenvironment in human fragility fracture bone

(2008) B. Hopwood et al.   BONE

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions

(2008) Jinhui Liao et al.   INTERNATIONAL JOURNAL OF CANCER