CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways

Hematological Diseases and Osteoporosis

(2020) Agostino Gaudio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hymenialdisine: A Marine Natural Product That Acts on Both Osteoblasts and Osteoclasts and Prevents Estrogen‐Dependent Bone Loss in Mice

(2020) Qingqing Wang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress

(2020) Shanshan Wan et al.   Oxidative Medicine and Cellular Longevity

A missense mutation sheds light on a novel structure–function relationship of RANKL

(2020) Heng Qiu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

(2019) Danielle Harmer et al.   Frontiers in Endocrinology

Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response

(2019) Yvette Zarb et al.   BRAIN

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

(2019) Lishan Li et al.   MicrobiologyOpen

Notch3 promotes prostate cancer-induced bone lesion development via MMP-3

(2019) Sourik S. Ganguly et al.   ONCOGENE

Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss

(2019) Yu-Ru V. Shih et al.   Science Advances

Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts

(2019) Jungeun Yu et al.   BONE

YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling

(2019) Christopher D Kegelman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tissue engineered bone mimetics to study bone disorders ex vivo : Role of bioinspired materials

(2018) Yuru Vernon Shih et al.   BIOMATERIALS

STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex

(2018) Eutteum Jeong et al.   CELL DEATH AND DIFFERENTIATION

Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis

(2018) Urszula Florczyk-Soluch et al.   Scientific Reports

Combination therapy of anabolic agents and bisphosphonates on bone mineral density in patients with osteoporosis: a meta-analysis of randomised controlled trials

(2018) Shenghan Lou et al.   BMJ Open

BMAL1 deficiency promotes skeletal mandibular hypoplasia via OPG downregulation

(2018) Xin Zhou et al.   CELL PROLIFERATION

Redox Signaling by Reactive Electrophiles and Oxidants

(2018) Saba Parvez et al.   CHEMICAL REVIEWS

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

(2018) Kyunghee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

(2017) Koichi Murata et al.   IMMUNITY

Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients

(2017) W.E. O'Gorman et al.   JOURNAL OF AUTOIMMUNITY

Physiological and pathophysiological bone turnover — role of the immune system

(2016) M. Neale Weitzmann et al.   Nature Reviews Endocrinology

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Cyclohexane, a Potential Drug of Abuse with Pernicious Effects on the Brain

(2016) Tania Campos-Ordonez et al.   Frontiers in Pharmacology

The 1,2,3-triazole derivative KP-A021 suppresses osteoclast differentiation and function by inhibiting RANKL-mediated MEK-ERK signaling pathway

(2015) Hye Jung Ihn et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Triterpenoid Saponin W3 from Anemone flaccida Suppresses Osteoclast Differentiation through Inhibiting Activation of MAPKs and NF-κB Pathways

(2015) Xiangying Kong et al.   International Journal of Biological Sciences

Chitosan nanofiber scaffold improves bone healing via stimulating trabecular bone production due to upregulation of the Runx2/osteocalcin/alkaline phosphatase signaling pathway

(2015) Ruei-Ming Chen et al.   International Journal of Nanomedicine

Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations

(2015) Y. Xue et al.   JOURNAL OF DENTAL RESEARCH

Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway

(2015) C Peng et al.   ONCOGENE

Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts

(2014) J H Kim et al.   CELL DEATH AND DIFFERENTIATION

Stem cells and the impact of ROS signaling

(2014) C. L. Bigarella et al.   DEVELOPMENT

Carboxypeptidase E Is a Novel Modulator of RANKL-Induced Osteoclast Differentiation

(2014) Hyun-Ju Kim et al.   MOLECULES AND CELLS

Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden

(2014) Khalid Abubaker et al.   Frontiers in Oncology

JAK/STAT signaling in hematological malignancies

(2012) W Vainchenker et al.   ONCOGENE

Prevention of Wear Particle-Induced Osteolysis by a Novel V-ATPase Inhibitor Saliphenylhalamide through Inhibition of Osteoclast Bone Resorption

(2012) An Qin et al.   PLoS One

Low Molecular Weight Hydroxyethyl Chitosan-Prednisolone Conjugate for Renal Targeting Therapy: Synthesis, Characterization and In Vivo Studies

(2012) Xia-kai He et al.   Theranostics

Lung dendritic cells at the innate-adaptive immune interface

(2011) Tracy Voss Condon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells

(2011) K A Monaghan et al.   LEUKEMIA

Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts

(2010) Elise Verron et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nox4 is a Novel Inducible Source of Reactive Oxygen Species in Monocytes and Macrophages and Mediates Oxidized Low Density Lipoprotein–Induced Macrophage Death

(2010) Chi Fung Lee et al.   CIRCULATION RESEARCH

CD47 Regulates Bone Mass and Tumor Metastasis to Bone

(2009) O. Uluckan et al.   CANCER RESEARCH

Parathyroid Hormone Induction of Cyclooxygenase-2 in Murine Osteoblasts: Role of the Calcium-Calcineurin-NFAT Pathway

(2009) Hechang Huang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Positive feedback regulation of maize NADPH oxidase by mitogen-activated protein kinase cascade in abscisic acid signalling

(2009) F. Lin et al.   JOURNAL OF EXPERIMENTAL BOTANY

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS