Nanobody GPS by PCS: An Efficient New NMR Analysis Method for G Protein Coupled Receptors and Other Large Proteins

Pseudocontact Shifts in Biomolecular NMR Spectroscopy

(2022) Thomas Müntener et al.   CHEMICAL REVIEWS

Paramagnetic Chemical Probes for Studying Biological Macromolecules

(2022) Qing Miao et al.   CHEMICAL REVIEWS

Nanobody: a promising toolkit for molecular imaging and disease therapy

(2021) Guangfa Bao et al.   EJNMMI Research

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

(2021) Polina Isaikina et al.   Science Advances

GPCR activation mechanisms across classes and macro/microscales

(2021) Alexander S. Hauser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches

(2020) Feng-Jie Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

(2020) Anne Grahl et al.   Nature Communications

GPCR Activation States Induced by Nanobodies and Mini-G Proteins Compared by NMR Spectroscopy

(2020) Philip Rößler et al.   MOLECULES

Molecular basis for high-affinity agonist binding in GPCRs

(2019) Tony Warne et al.   SCIENCE

High pressure shifts the β1-adrenergic receptor to the active conformation in the absence of G protein

(2019) Layara Akemi Abiko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and applications of lanthanide chelating tags for pseudocontact shift NMR spectroscopy with biomacromolecules

(2019) Daniel Joss et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New Lanthanide Chelating Tags for PCS NMR Spectroscopy with Reduction Stable, Rigid Linkers for Fast and Irreversible Conjugation to Proteins

(2018) Thomas Müntener et al.   BIOCONJUGATE CHEMISTRY

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

(2017) Andras S. Solt et al.   Nature Communications

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

(2016) Shin Isogai et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

(2015) Junya Okude et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

Bringing Dynamic Molecular Machines into Focus by Methyl-TROSY NMR

(2014) Rina Rosenzweig et al.   Annual Review of Biochemistry

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

(2014) Aashish Manglik et al.   CURRENT OPINION IN CELL BIOLOGY

A general protocol for the generation of Nanobodies for structural biology

(2014) Els Pardon et al.   Nature Protocols

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

(2012) Yutaka Kofuku et al.   Nature Communications

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Engineering Encodable Lanthanide-Binding Tags into Loop Regions of Proteins

(2010) Katja Barthelmes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assignment of Ile, Leu, and Val Methyl Correlations in Supra-Molecular Systems: An Application to Aspartate Transcarbamoylase

(2009) Algirdas Velyvis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DOTA-M8: An Extremely Rigid, High-Affinity Lanthanide Chelating Tag for PCS NMR Spectroscopy

(2009) Daniel Häussinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE