Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
Authors
Keywords
-
Journal
Nature Communications
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-11-21
DOI
10.1038/s41467-017-02008-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- GPCRdb: the G protein-coupled receptor database - an introduction
- (2016) C Munk et al. BRITISH JOURNAL OF PHARMACOLOGY
- Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer
- (2016) Marina Casiraghi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure of the adenosine A2A receptor bound to an engineered G protein
- (2016) Byron Carpenter et al. NATURE
- Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor
- (2016) Shin Isogai et al. NATURE
- Activation of the A2A adenosine G-protein-coupled receptor by conformational selection
- (2016) Libin Ye et al. NATURE
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
- (2016) A. J. Venkatakrishnan et al. NATURE
- A comprehensive map of molecular drug targets
- (2016) Rita Santos et al. NATURE REVIEWS DRUG DISCOVERY
- Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor
- (2015) Junya Okude et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- Structures of G protein-coupled receptors reveal new opportunities for drug discovery
- (2015) Robert M. Cooke et al. DRUG DISCOVERY TODAY
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Propagation of conformational changes during μ-opioid receptor activation
- (2015) Rémy Sounier et al. NATURE
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR
- (2015) Rajan Lamichhane et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy
- (2014) Yutaka Kofuku et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor
- (2014) Jennifer L. Miller-Gallacher et al. PLoS One
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor
- (2013) Tae Hun Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
- (2013) Aaron M. Ring et al. NATURE
- Agonist-bound structures of G protein-coupled receptors
- (2012) Guillaume Lebon et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Compressed sensing reconstruction of undersampled 3D NOESY spectra: application to large membrane proteins
- (2012) Mark J. Bostock et al. JOURNAL OF BIOMOLECULAR NMR
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
- (2012) Yutaka Kofuku et al. Nature Communications
- Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation
- (2011) Guillaume Lebon et al. NATURE
- The structural basis for agonist and partial agonist action on a β1-adrenergic receptor
- (2011) Tony Warne et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- The pharmacological effects of the thermostabilising (m23) mutations and intra and extracellular (β36) deletions essential for crystallisation of the turkey β-adrenoceptor
- (2011) Jillian G. Baker et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Activation mechanism of the 2-adrenergic receptor
- (2011) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Poisson-Gap Sampling and Forward Maximum Entropy Reconstruction for Enhancing the Resolution and Sensitivity of Protein NMR Data
- (2010) Sven G. Hyberts et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- Structure of a β1-adrenergic G-protein-coupled receptor
- (2008) Tony Warne et al. NATURE
- Structural diversity of G protein-coupled receptors and significance for drug discovery
- (2008) Malin C. Lagerström et al. NATURE REVIEWS DRUG DISCOVERY
- Conformational thermostabilization of the 1-adrenergic receptor in a detergent-resistant form
- (2008) M. J. Serrano-Vega et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started