Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor
Authors
Keywords
-
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 52, Pages 15771-15776
Publisher
Wiley
Online
2015-11-16
DOI
10.1002/anie.201508794
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- The dynamics of the G protein-coupled neuropeptide Y2 receptor in monounsaturated membranes investigated by solid-state NMR spectroscopy
- (2015) Lars Thomas et al. JOURNAL OF BIOMOLECULAR NMR
- Structural insights into µ-opioid receptor activation
- (2015) Weijiao Huang et al. NATURE
- Propagation of conformational changes during μ-opioid receptor activation
- (2015) Rémy Sounier et al. NATURE
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy
- (2014) Yutaka Kofuku et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The G-Protein-Coupled Neuropeptide Y Receptor Type 2 is Highly Dynamic in Lipid Membranes as Revealed by Solid-State NMR Spectroscopy
- (2014) Peter Schmidt et al. CHEMISTRY-A EUROPEAN JOURNAL
- Molecular control of δ-opioid receptor signalling
- (2014) Gustavo Fenalti et al. NATURE
- Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers
- (2014) David G. Soergel et al. PAIN
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers
- (2013) David G. Soergel et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain
- (2013) Xiao-Tao Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
- (2012) Ka Young Chung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
- (2012) Aashish Manglik et al. NATURE
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
- (2012) Yutaka Kofuku et al. Nature Communications
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors
- (2011) John A. Allen et al. Annual Review of Pharmacology and Toxicology
- Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors
- (2011) Eric Reiter et al. Annual Review of Pharmacology and Toxicology
- The structural basis of agonist-induced activation in constitutively active rhodopsin
- (2011) Jörg Standfuss et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers
- (2010) Chie Yoshiura et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization
- (2010) J. McPherson et al. MOLECULAR PHARMACOLOGY
- Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
- (2010) Michael P. Bokoch et al. NATURE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started