Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice

Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics

(2022) Hidefumi Mukai et al.   Drug Metabolism and Pharmacokinetics

Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size

(2022) Jiaxing Di et al.   PHARMACEUTICAL RESEARCH

Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain

(2022) Koki Ogawa et al.   JOURNAL OF CONTROLLED RELEASE

Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability

(2022) Mariko Kamiya et al.   Pharmaceutics

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

(2021) Nigel Davies et al.   Molecular Therapy-Nucleic Acids

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

(2021) Federica Sebastiani et al.   ACS Nano

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

(2021) Pooria Nakhaei et al.   Frontiers in Bioengineering and Biotechnology

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

(2021) Manuel J. Carrasco et al.   Communications Biology

Non-liver mRNA Delivery

(2021) David Loughrey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice

(2021) Natsuko Oyama et al.   Pharmaceutics

The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution

(2020) Takashi Nakamura et al.   MOLECULAR PHARMACEUTICS

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery

(2020) Hiroki Tanaka et al.   ADVANCED FUNCTIONAL MATERIALS

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

(2020) Evan J. Anderson et al.   NEW ENGLAND JOURNAL OF MEDICINE

APOE polymorphism in ATTR amyloidosis patients treated with lipid nanoparticle siRNA

(2019) Christoph Niemietz et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Observation of liposomes of differing lipid composition in aqueous medium by means of atomic force microscopy

(2016) Yuki Takechi-Haraya et al.   Microscopy

Physical Principles of Nanoparticle Cellular Endocytosis

(2015) Sulin Zhang et al.   ACS Nano

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

(2014) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery

(2009) Deepa A. Rao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES