Design, Synthesis, and Bioactivity Investigation of Cyclic Lipopeptide Antibiotics Containing Eight to Nine Amino Acids

Hydrophobicity Determines the Bacterial Killing Rate of α-Helical Antimicrobial Peptides and Influences the Bacterial Resistance Development

(2022) Minghui Zhang et al.   Journal of Medicinal Chemistry

The Low-Alkalinity Polymyxin Derivative, AL-6, Shows High Activity Against Multidrug-Resistant Acinetobacter baumannii Clinical Isolates In Vitro and A. baumannii ATCC 19606 In Vivo: Preliminary Analysis of the Antibacterial Mechanism

(2021) Dai-Jie Chen et al.   Microbial Drug Resistance

Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin

(2021) Pamela Brown et al.   ACS Infectious Diseases

Interactions of Linear Analogues of Battacin with Negatively Charged Lipid Membranes

(2021) Kinga Burdach et al.   Membranes

Agents of Last Resort

(2020) Qiwen Yang et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

(2020) Xukai Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

(2018) Ronald Domalaon et al.   CLINICAL MICROBIOLOGY REVIEWS

Can octapeptin antibiotics combat extensively drug-resistant (XDR) bacteria?

(2018) Mark A. T. Blaskovich et al.   Expert Review of Anti-Infective Therapy

Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics

(2018) A-Long Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin

(2018) Martti Vaara   MEDICINAL RESEARCH REVIEWS

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

(2018) Elena K. Schneider-Futschik et al.   ACS Infectious Diseases

An overview of antimicrobial peptides and the latest advances in their development

(2017) Josep M Sierra et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Rediscovering the octapeptins

(2017) Tony Velkov et al.   NATURAL PRODUCT REPORTS

Polymyxin Resistance in Gram-negative Pathogens

(2017) Pavithra Srinivas et al.   Current Infectious Disease Reports

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

(2017) Mei-Ling Han et al.   ACS Infectious Diseases

Antimicrobial Peptides with Potential for Biofilm Eradication: Synthesis and Structure Activity Relationship Studies of Battacin Peptides

(2015) Gayan Heruka De Zoysa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Resistance to rifampicin: a review

(2014) Beth P Goldstein   JOURNAL OF ANTIBIOTICS

Novel derivatives of polymyxins

(2013) M. Vaara   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-Resistant Gram-Negative Bacteria

(2011) Chao-Dong Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiresistant Gram-negative infections: a global perspective

(2010) Jennifer Ho et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY