Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin

Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity

(2020) Pamela Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics

(2019) Martti Vaara   MOLECULES

Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, An Intravenous Potentiator, After Single and Multiple Ascending Doses and When Combined with Beta-Lactam Antibiotics in Healthy Subjects

(2019) Paul B. Eckburg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The “Old” and the “New” Antibiotics for MDR Gram-Negative Pathogens: For Whom, When, and How

(2019) Ilias Karaiskos et al.   Frontiers in Public Health

Polymyxin B analog SPR741 potentiates antibiotics against Gram-negative bacteria and uniquely perturbs the outer membrane

(2019) Shawn French et al.   ACS Infectious Diseases

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206

(2019) Pamela Brown et al.   ACS Infectious Diseases

Plastic binding feature of polymyxins: the effect on MIC susceptibility measurements

(2019) Toktam Sharafi et al.   Infection and Drug Resistance

Evaluation of the Rapid Polymyxin NP test and its industrial version for the detection of polymyxin-resistant Enterobacteriaceae

(2018) Aurélie Jayol et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

New polymyxin derivatives that display improved efficacy in animal infection models as compared to polymyxin B and colistin

(2018) Martti Vaara   MEDICINAL RESEARCH REVIEWS

β-lactam/β-lactamase inhibitor combinations: an update

(2018) Kamaleddin H. M. E. Tehrani et al.   MedChemComm

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

(2017) Pamela Brown et al.   JOURNAL OF ANTIBIOTICS

Structure–activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity

(2017) Martti Vaara et al.   PEPTIDES

Polymyxin: Alternative Mechanisms of Action and Resistance

(2016) Michael J. Trimble et al.   Cold Spring Harbor Perspectives in Medicine

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

(2015) Roger L Nation et al.   LANCET INFECTIOUS DISEASES

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

(2014) Tony Velkov et al.   ACS Chemical Biology

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Discovery of Dap-3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections

(2013) Thomas V. Magee et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of Lipopolysaccharide and Polymyxin Studied by NMR Spectroscopy

(2009) Jiri Mares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY