Antagonizing EZH2 combined with vitamin D3 exerts a synergistic role in anti‐fibrosis through bidirectional effects on hepatocytes and hepatic stellate cells

EZH2‐mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ

(2021) Zhipeng Du et al.   CELL PROLIFERATION

Ezh2‐dependent H3K27me3 modification dynamically regulates vitamin D3‐dependent epigenetic control of CYP24A1 gene expression in osteoblastic cells

(2020) Daniel Moena et al.   JOURNAL OF CELLULAR PHYSIOLOGY

25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor

(2020) Ahmad Salhab et al.   BMC GASTROENTEROLOGY

Sorafenib reduces steatosis‐induced fibrogenesis in a human 3D co‐culture model of non‐alcoholic fatty liver disease

(2020) Guilherme Ribeiro Romualdo et al.   ENVIRONMENTAL TOXICOLOGY

Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1‐mediated PTEN hypermethylation in HSC activation and proliferation

(2020) Hong Zhu et al.   FASEB JOURNAL

Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?

(2020) Alex Claveria-Cabello et al.   Cells

Leptin induces NAFLD progression through infiltrated CD8+ T lymphocytes mediating pyroptotic-like cell death of hepatocytes and macrophages

(2020) Qinghui Zhang et al.   DIGESTIVE AND LIVER DISEASE

5‐ARI induces autophagy of prostate epithelial cells through suppressing IGF‐1 expression in prostate fibroblasts

(2019) Bo‐Yu Yang et al.   CELL PROLIFERATION

Interaction of transforming growth factor-β-Smads/microRNA-362-3p/CD82 mediated by M2 macrophages promotes the process of epithelial-mesenchymal transition in hepatocellular carcinoma cells

(2019) Qinghui Zhang et al.   CANCER SCIENCE

1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis

(2019) Renlei Yang et al.   AGING CELL

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts

(2018) Changwei Dou et al.   GASTROENTEROLOGY

Homocysteine activates autophagy by inhibition of CFTR expression via interaction between DNA methylation and H3K27me3 in mouse liver

(2018) Anning Yang et al.   Cell Death & Disease

PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling

(2018) Qinghui Zhang et al.   PPAR Research

Aberrant activation of β-catenin signaling drives glioma tumorigenesis via USP1-mediated stabilization of EZH2

(2018) Li Ma et al.   CANCER RESEARCH

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells

(2015) Agata Page et al.   JOURNAL OF HEPATOLOGY

Anti-miR-197 inhibits migration in HCC cells by targeting KAI 1/CD82

(2014) Weiqi Dai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma

(2014) Laura Bergadà et al.   LABORATORY INVESTIGATION

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Illuminating liver fibrosis with vitamin D

(2013) D. Firrincieli et al.   Clinics and Research in Hepatology and Gastroenterology

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

(2012) Maria Jesus Perugorria et al.   HEPATOLOGY