Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1‐mediated PTEN hypermethylation in HSC activation and proliferation

Therapeutic effects of AdipoRon on liver inflammation and fibrosis induced by CCl4 in mice

(2020) Min Sha et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of microbiota GLP1 axis by sennoside A in diet-induced obese mice

(2019) Jiamei Le et al.   Acta Pharmaceutica Sinica B

PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice

(2019) Xiaobo Zhu et al.   ANNALS OF THE RHEUMATIC DISEASES

Application of screening methods for weight-loss compounds and identification of new impurities in counterfeit drugs

(2019) Ji Hyun Lee et al.   FORENSIC SCIENCE INTERNATIONAL

Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

(2019) Olga Khomich et al.   Cells

Sennoside A protects mitochondrial structure and function to improve high-fat diet-induced hepatic steatosis by targeting VDAC1

(2018) Jiamei Le et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis

(2018) Wenting Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats

(2018) Yixin Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Epigenetics in Liver Fibrosis

(2017) Veronica Massey et al.   SEMINARS IN LIVER DISEASE

Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis

(2017) Yuting Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

(2017) Dominika E. Butler et al.   Oncotarget

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Hyaluronic acid–tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis

(2015) Jeong-A Yang et al.   Acta Biomaterialia

Periostin down-regulation attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-β1

(2015) Li Hong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation

(2015) Fujun Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway

(2015) Zhen Yang et al.   Oncotarget

Nanotechnology applications for the therapy of liver fibrosis

(2014) Lydia Giannitrapani   WORLD JOURNAL OF GASTROENTEROLOGY

Inactivation of myofibroblasts during regression of liver fibrosis

(2013) Tatiana Kisseleva et al.   CELL CYCLE

The epigenetic feedback loop between DNA methylation and microRNAs in fibrotic disease with an emphasis on DNA methyltransferases

(2013) Xu Sun et al.   CELLULAR SIGNALLING

DNA methylation and MeCP2 regulation of PTCH1 expression during rats hepatic fibrosis

(2013) Jing-Jing Yang et al.   CELLULAR SIGNALLING

Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation - a novel mechanism suppressing liver fibrosis

(2013) Jianjian Zheng et al.   FEBS Journal

Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in anin vivorat model

(2012) In Hee Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Epigenetic Regulation of Gene Expression as an Anticancer Drug Target

(2011) L. R. Ferguson et al.   CURRENT CANCER DRUG TARGETS

Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B

(2010) Ting-Tsung Chang et al.   HEPATOLOGY

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Reversal of liver fibrosis

(2009) MonaH Ismail et al.   Saudi Journal of Gastroenterology

Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells

(2008) Nong Xiang et al.   CARCINOGENESIS

The PTEN/PI3K/AKT Signalling Pathway in Cancer, Therapeutic Implications

(2008) Amancio Carnero et al.   CURRENT CANCER DRUG TARGETS

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY