EZH2‐mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ

Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis‐PROX1‐HIF‐1α in liver fibrosis

(2020) Xiang Yang et al.   CELL PROLIFERATION

Epigenetic Therapy for Epithelioid Sarcoma

(2020) Scott B. Rothbart et al.   CELL

Tazemetostat: First Approval

(2020) Sheridan M. Hoy   DRUGS

SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway

(2020) Zhipeng Du et al.   LABORATORY INVESTIGATION

Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective

(2019) Jia Xiao et al.   JOURNAL OF HEPATOLOGY

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

(2019) Hao Wu et al.   CELL PROLIFERATION

EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway

(2019) Hanwen Zhang et al.   ONCOGENE

Mediator MED23 regulates inflammatory responses and liver fibrosis

(2019) Zhichao Wang et al.   PLOS BIOLOGY

rSjP40 protein promotes PPARγ expression in LX-2 cells through microRNA-27b

(2018) Dandan Zhu et al.   FASEB JOURNAL

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

(2018) Min Li et al.   FASEB JOURNAL

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study

(2018) Antoine Italiano et al.   LANCET ONCOLOGY

Hypermethylation of TRIM59 and KLF14 Influences Cell Death Signaling in Familial Alzheimer’s Disease

(2018) Michalina Wezyk et al.   Oxidative Medicine and Cellular Longevity

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

(2018) Feng Zhang et al.   Theranostics

LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14

(2018) Jianwei Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KLF14 potentiates oxidative adaptation via modulating HO-1 signaling in castrate-resistant prostate cancer

(2018) Xiao-hui Luo et al.   ENDOCRINE-RELATED CANCER

LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis

(2018) Yu-Gang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Overexpression of KLF14 protects against immune-mediated hepatic injury in mice

(2018) Xiaoyan Chen et al.   LABORATORY INVESTIGATION

Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis

(2018) Xin Chen et al.   Cell Death & Disease

Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

(2018) Jung Kim et al.   Cell Reports

Detection and evaluation of DNA methylation markers found at SCGN and KLF14 loci to estimate human age

(2017) Hussain Alghanim et al.   Forensic Science International-Genetics

Chronological age prediction based on DNA methylation: Massive parallel sequencing and random forest regression

(2017) Jana Naue et al.   Forensic Science International-Genetics

The KLF14 transcription factor regulates hepatic gluconeogenesis in mice

(2017) Lu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study

(2016) L. Kananen et al.   BMC GENOMICS

Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence

(2016) H Jin et al.   Cell Death & Disease

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

(2016) Karl Bacos et al.   Nature Communications

Histone H3K9 demethylase JMJD1A modulates hepatic stellate cells activation and liver fibrosis by epigenetically regulating peroxisome proliferator-activated receptor γ

(2015) Yan Jiang et al.   FASEB JOURNAL

Resveratrol Regulates the Quiescence-Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio

(2015) Izabel Cristina Custódio de Souza et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production

(2015) Yanhong Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of KLF14 triggers centrosome amplification and tumorigenesis

(2015) Guangjian Fan et al.   Nature Communications

New Role for Kruppel-like Factor 14 as a Transcriptional Activator Involved in the Generation of Signaling Lipids

(2014) Thiago M. de Assuncao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

(2013) S. K. Knutson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors ofKRAS-mediated cell growth

(2011) Martin E. Fernandez-Zapico et al.   BIOCHEMICAL JOURNAL

Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes

(2011) Patrick Sauvant et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

(2011) Kerrin S Small et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cellsin vitroandin vivo

(2009) Inge Mannaerts et al.   HEPATOLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Silencing of the Transforming Growth Factor-β (TGFβ) Receptor II by Krüppel-like Factor 14 Underscores the Importance of a Negative Feedback Mechanism in TGFβ Signaling

(2008) Mark J. Truty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like transcription factors: A functional family

(2007) Richard Pearson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY