Therapeutic Potential of Plant Oxylipins

Structural diversity, biosynthesis, and function of plant falcarin-type polyacetylenic lipids

(2022) Patrícia Santos et al.   JOURNAL OF EXPERIMENTAL BOTANY

Virtual screening of phytochemicals from Indian medicinal plants against the endonuclease domain of SFTS virus L polymerase

(2022) R. P. Vivek-Ananth et al.   RSC Advances

Phytoprostanes and phytofurans modulate COX-2-linked inflammation markers in LPS-stimulated THP-1 monocytes by lipidomics workflow

(2021) María Campillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance

(2021) Rana Ezzeddini et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders

(2021) Oritoke Modupe Aluko et al.   Clinical Psychopharmacology and Neuroscience

Glutathione S-Transferases in Cancer

(2021) Rahul Raj Singh et al.   Antioxidants

Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections

(2021) Vladimir Y Gorshkov et al.   ANNALS OF BOTANY

Therapeutic Potential of Jasmonic Acid and Its Derivatives

(2021) Iwona Jarocka-Karpowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

(2021) Kamila P. Liput et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Possible Protective Effects of TA on the Cancerous Effect of Mesotrione

(2020) Agata Jabłońska-Trypuć et al.   Nutrients

PPAR Beta/Delta and the Hallmarks of Cancer

(2020) Nicole Wagner et al.   Cells

Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

(2020) Omar S. Ahmed et al.   Essays in Biochemistry

Multiple Roles of Diatom-Derived Oxylipins within Marine Environments and Their Potential Biotechnological Applications

(2020) Nadia Ruocco et al.   Marine Drugs

Bioactive C17 and C18 Acetylenic Oxylipins from Terrestrial Plants as Potential Lead Compounds for Anticancer Drug Development

(2020) Lars Porskjær Christensen   MOLECULES

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

(2020) Farhana Rumzum Bhuiyan et al.   Frontiers in Medicine

Methyl jasmonate reverses chronic stress-induced memory dysfunctions through modulation of monoaminergic neurotransmission, antioxidant defense system, and Nrf2 expressions

(2020) Oritoke M. Aluko et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Isolation and Antitrypanosomal Characterization of Furoquinoline and Oxylipin from Zanthoxylum zanthoxyloides

(2020) Aboagye Kwarteng Dofuor et al.   Biomolecules

Efficient Syntheses of Traumatic Lactone and Rhizobialide

(2019) Jing Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Toxicological Effects of Traumatic Acid and Selected Herbicides on Human Breast Cancer Cells: In Vitro Cytotoxicity Assessment of Analyzed Compounds

(2019) Agata Jabłońska-Trypuć et al.   MOLECULES

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders

(2019) Airi Jo-Watanabe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxygenated C17 polyacetylene metabolites from Algerian Eryngium tricuspidatum L. roots: Structure and biological activity

(2019) A. Djebara et al.   FITOTERAPIA

Methyl jasmonate ameliorates rotenone-induced motor deficits in rats through its neuroprotective activity and increased expression of tyrosine hydroxylase immunopositive cells

(2019) Akinyinka O. Alabi et al.   METABOLIC BRAIN DISEASE

Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice

(2019) Akinyinka O. Alabi et al.   NEUROTOXICOLOGY

Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells

(2019) Agata Jabłońska-Trypuć et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Impact of jasmonates on safety, productivity and physiology of food crops

(2019) Mohammadreza Asghari   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Phenolic, oxylipin and fatty acid profiles of the Chilean hazelnut (Gevuina avellana): Antioxidant activity and inhibition of pro-inflammatory and metabolic syndrome-associated enzymes

(2019) Liudis Leidy Pino Ramos et al.   FOOD CHEMISTRY

Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats

(2019) Pereira-Maróstica et al.   Antioxidants

Plant–Pathogen Interactions: Underestimated Roles of Phyto-oxylipins

(2019) Estelle Deboever et al.   TRENDS IN PLANT SCIENCE

Microalgae-derived oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ

(2018) Javier Ávila-Román et al.   PHARMACOLOGICAL RESEARCH

Jasmonates: News on Occurrence, Biosynthesis, Metabolism and Action of an Ancient Group of Signaling Compounds

(2018) Claus Wasternack et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of α-glucosidase and α-amylase by Spanish extra virgin olive oils: The involvement of bioactive compounds other than oleuropein and hydroxytyrosol

(2017) Jacinta Collado-González et al.   FOOD CHEMISTRY

Methyl jasmonate: a phytohormone with potential for the treatment of inflammatory bowel diseases

(2017) Jean Carlos Fernando Besson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice

(2017) Adaeze Adebesin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Probable mechanisms involved in the antipsychotic-like activity of methyl jasmonate in mice

(2017) Olajide S. Annafi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effects of the plant volatile trans ‑2-hexenal on the dispersal ability, nutrient metabolism and enzymatic activities of Bursaphelenchus xylophilus

(2017) Yunhe Zhao et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

(2017) Jean-Marie Galano et al.   PROGRESS IN LIPID RESEARCH

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

(2016) Darren J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia

(2016) Nozomi Taki-Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The novelty of phytofurans, isofurans, dihomo-isofurans and neurofurans: Discovery, synthesis and potential application

(2016) Claire Cuyamendous et al.   BIOCHIMIE

Evaluation of adaptogenic-like property of methyl jasmonate in mice exposed to unpredictable chronic mild stress

(2016) Solomon Umukoro et al.   BRAIN RESEARCH BULLETIN

Anti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis model

(2016) Javier Ávila-Román et al.   BRITISH JOURNAL OF NUTRITION

Thermal Stress in Melon Plants: Phytoprostanes and Phytofurans as Oxidative Stress Biomarkers and the Effect of Antioxidant Supplementation

(2016) Melisa E. Yonny et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts

(2016) Agata Jabłońska-Trypuć et al.   LIPIDS

Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers

(2015) Jean-Marie Galano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice

(2015) Anthony T. Eduviere et al.   LIFE SCIENCES

Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA2Signaling Pathway

(2015) Maria Karmella Apaya et al.   MOLECULAR MEDICINE

Green leaf volatiles: biosynthesis, biological functions and their applications in biotechnology

(2015) Muhammad Naeem ul Hassan et al.   PLANT BIOTECHNOLOGY JOURNAL

A Review (Research and Patents) on Jasmonic Acid and Its Derivatives

(2014) Abdollah Ghasemi Pirbalouti et al.   ARCHIV DER PHARMAZIE

Nonenzymatic oxygenated metabolites of α-linolenic acid B1- and L1-phytoprostanes protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte progenitors through PPAR-γ activation

(2014) Luisa Minghetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary Acetylenic Oxylipin Falcarinol Differentially Modulates GABAA Receptors

(2014) Marta Magdalena Czyzewska et al.   JOURNAL OF NATURAL PRODUCTS

Arachidonic acid-dependent carbon-eight volatile synthesis from wounded liverwort (Marchantia polymorpha)

(2014) Hirotomo Kihara et al.   PHYTOCHEMISTRY

Diatom-Derived Polyunsaturated Aldehydes Activate Cell Death in Human Cancer Cell Lines but Not Normal Cells

(2014) Clementina Sansone et al.   PLoS One

Jasmonates: biosynthesis, perception, signal transduction and action in plant stress response, growth and development. An update to the 2007 review in Annals of Botany

(2013) C. Wasternack et al.   ANNALS OF BOTANY

Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis

(2013) Q. J. Wu et al.   ANNALS OF ONCOLOGY

ROS-Mediated Lipid Peroxidation and RES-Activated Signaling

(2013) Edward E. Farmer et al.   Annual Review of Plant Biology

The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves

(2013) Antonietta Bernardo et al.   BIOLOGICAL CHEMISTRY

Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101

(2013) Yongjun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cruciferous vegetable consumption and gastric cancer risk: A meta-analysis of epidemiological studies

(2013) Qi-Jun Wu et al.   CANCER SCIENCE

Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA

(2013) Miao Liu et al.   JOURNAL OF LIPID RESEARCH

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

Apoptotic anticancer activity of a novel fatty alcohol ester isolated from cultured marine diatom, Phaeodactylum tricornutum

(2013) Kalpa W. Samarakoon et al.   Journal of Functional Foods

Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies

(2012) Q. J. Wu et al.   ANNALS OF ONCOLOGY

In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates

(2012) Hung The Dang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The anti-cancer activities of jasmonates

(2012) Ziv Raviv et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A non-canonical caleosin fromArabidopsisefficiently epoxidizes physiological unsaturated fatty acids with complete stereoselectivity

(2012) Elizabeth Blée et al.   FEBS Journal

Fragrance material review on methyl dihydrojasmonate

(2012) J. Scognamiglio et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolomic Analysis of Patient Plasma Yields Evidence of Plant-Like α-Linolenic Acid Metabolism in Plasmodium falciparum

(2012) Viswanathan Lakshmanan et al.   JOURNAL OF INFECTIOUS DISEASES

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Anti-aggressive activity of methyl jasmonate and the probable mechanism of its action in mice

(2012) Solomon Umukoro et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Insect herbivores selectively suppress the HPL branch of the oxylipin pathway in host plants

(2012) Tatyana Savchenko et al.   PLANT JOURNAL

NaJAZh Regulates a Subset of Defense Responses against Herbivores and Spontaneous Leaf Necrosis in Nicotiana attenuata Plants

(2012) Y. Oh et al.   PLANT PHYSIOLOGY

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

Fruit, Vegetables, and Folate: Cultivating the Evidence for Cancer Prevention

(2011) Jung Eun Lee et al.   GASTROENTEROLOGY

Enhanced Glucosinolates in Root Exudates of Brassica rapa ssp.rapaMediated by Salicylic Acid and Methyl Jasmonate

(2011) Monika Schreiner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

C12 derivatives of the hydroperoxide lyase pathway are produced by product recycling through lipoxygenase-2 in Nicotiana attenuata leaves

(2011) Mario Kallenbach et al.   NEW PHYTOLOGIST

Apoptotic activity of the marine diatomCocconeis scutellumand eicosapentaenoic acid in BT20 cells

(2011) Michela Nappo et al.   PHARMACEUTICAL BIOLOGY

Anti-inflammatory effect of methyl dehydrojasmonate (J2) is mediated by the NF-κB pathway

(2010) Hye-Ja Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

High Throughput Extraction of Plant, Marine and Fungal Specimens for Preservation of Biologically Active Molecules

(2010) Thomas G. McCloud   MOLECULES

Detection of genotoxicants in Brassicales using endogenous DNA as a surrogate target and adducts determined by 32P-postlabelling as an experimental end point

(2010) C. Baasanjav-Gerber et al.   MUTAGENESIS

Momordicatin purified from fruits of Momordica charantia is effective to act as a potent antileishmania agent

(2010) Shreedhara Gupta et al.   PARASITOLOGY INTERNATIONAL

Antidepressant activity of methyl jasmonate, a plant stress hormone in mice

(2010) Solomon Umukoro et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Arachidonic Acid: An Evolutionarily Conserved Signaling Molecule Modulates Plant Stress Signaling Networks

(2010) Tatyana Savchenko et al.   PLANT CELL

Cyclin D1 Degradation Is Sufficient to Induce G1 Cell Cycle Arrest despite Constitutive Expression of Cyclin E2 in Ovarian Cancer Cells

(2009) C. P. Masamha et al.   CANCER RESEARCH

Successful Structure-Based Design of Recent p38 MAP Kinase Inhibitors

(2009) Solveigh Karcher et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation

(2009) P. Chen et al.   FEBS LETTERS

New antibacterial and cytotoxic activities of falcarindiol isolated in Crithmum maritimum L. leaf extract

(2009) Laetitia Meot-Duros et al.   FOOD AND CHEMICAL TOXICOLOGY

Differential Effects of Falcarinol and Related Aliphatic C17-Polyacetylenes on Intestinal Cell Proliferation

(2009) Stig Purup et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pollen-Derived E1-Phytoprostanes Signal via PPAR-  and NF- B-Dependent Mechanisms

(2009) S. Gilles et al.   JOURNAL OF IMMUNOLOGY

New Bioactive Oxylipins Formed by Non-Enzymatic Free-Radical-Catalyzed Pathways: the Phytoprostanes

(2009) Thierry Durand et al.   LIPIDS

15-Hydroxyeicosatetraenoic Acid Is a Preferential Peroxisome Proliferator-Activated Receptor  /  Agonist

(2009) S. Naruhn et al.   MOLECULAR PHARMACOLOGY

(+)-7-iso-Jasmonoyl-L-isoleucine is the endogenous bioactive jasmonate

(2009) Sandra Fonseca et al.   Nature Chemical Biology

Methyl jasmonate: A plant stress hormone as an anti-cancer drug

(2009) Sharon Cohen et al.   PHYTOCHEMISTRY

Lipoxygenases – Structure and reaction mechanism

(2009) Alexandra Andreou et al.   PHYTOCHEMISTRY

The leishmanicidal effect of (3S)-16,17-didehydrofalcarinol, an oxylipin isolated fromTridax procumbens, is independent of NO production

(2009) Zhelmy Martín-Quintal et al.   PHYTOTHERAPY RESEARCH

Roles of a membrane-bound caleosin and putative peroxygenase in biotic and abiotic stress responses in Arabidopsis

(2009) Mark Partridge et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Biosynthesis of oxylipins in non-mammals

(2009) Alexandra Andreou et al.   PROGRESS IN LIPID RESEARCH

Natural jasmonates of different structures suppress the growth of human neuroblastoma cell line SH-SY5Y and its mechanisms1

(2008) Qiang-song TONG et al.   ACTA PHARMACOLOGICA SINICA

New jasmonate analogues as potential anti-inflammatory agents

(2008) Hung The Dang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells

(2008) Tatiana Kniazhanski et al.   CANCER LETTERS

Acaricidal effects of natural six-carbon and nine-carbon aldehydes on stored-product mites

(2008) Jan Hubert et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

Purple Carrot (Daucus carota L.) Polyacetylenes Decrease Lipopolysaccharide-Induced Expression of Inflammatory Proteins in Macrophage and Endothelial Cells

(2008) Brandon T. Metzger et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

(2008) Dong-Sun Lee et al.   NATURE

Panaxydol and panaxynol protect cultured cortical neurons against Aβ25–35-induced toxicity

(2008) Bao-Ming Nie et al.   NEUROPHARMACOLOGY

Antimycobacterial polyacetylenes fromLevisticum officinale

(2008) Andreas Schinkovitz et al.   PHYTOTHERAPY RESEARCH

Oxylipins: Structurally diverse metabolites from fatty acid oxidation

(2008) Alina Mosblech et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Evidence for communality in the primary determinants of CYP74 catalysis and of structural similarities between CYP74 and classical mammalian P450 enzymes

(2008) Richard K. Hughes et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Host-derived lipids and oxylipins are crucial signals in modulating mycotoxin production by fungi

(2008) Xiquan Gao et al.   Toxin Reviews

Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology

(2008) Hedi Harizi et al.   TRENDS IN MOLECULAR MEDICINE

Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua

(2007) Ashish Baldi et al.   BIORESOURCE TECHNOLOGY