Fucoidan, as an immunostimulator promotes M1 macrophage differentiation and enhances the chemotherapeutic sensitivity of capecitabine in colon cancer

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Impact of Tumor-associated Macrophages on Chemoresistance via Angiogenesis in Colorectal Cancer

(2021) MASATSUNE SHIBUTANI et al.   ANTICANCER RESEARCH

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

(2021) Yongmei Zhao et al.   Pharmaceutics

Oligo-Fucoidan Prevents M2 Macrophage Differentiation and HCT116 Tumor Progression

(2020) Li-Mei Chen et al.   Cancers

The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations

(2020) Yuan Lin et al.   Cancer Cell International

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer

(2020) Marek Nowak et al.   Cells

A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems

(2020) Catarina Oliveira et al.   CARBOHYDRATE POLYMERS

Nucleic Acid Sensors as Therapeutic Targets for Human Disease

(2020) Sarah M. McWhirter et al.   IMMUNITY

Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy

(2020) Elke Kaemmerer et al.   DRUG DISCOVERY TODAY

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

(2019) Geert van Weelden et al.   Marine Drugs

M2 macrophages confer resistance to 5-fluorouracil in colorectal cancer through the activation of CCL22/PI3K/AKT signaling

(2019) Chen Wei et al.   OncoTargets and Therapy

A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator

(2019) Fan Su et al.   CARBOHYDRATE POLYMERS

Modulating the tumor microenvironment with new therapeutic nanoparticles: A promising paradigm for tumor treatment

(2019) Yinlong Zhang et al.   MEDICINAL RESEARCH REVIEWS

Sophoridine suppresses macrophage-mediated immunosuppression through TLR4/IRF3 pathway and subsequently upregulates CD8+ T cytotoxic function against gastric cancer

(2019) Haiwen Zhuang et al.   BIOMEDICINE & PHARMACOTHERAPY

TLR 7/8 agonist reverses oxaliplatin resistance in colorectal cancer via directing the myeloid-derived suppressor cells to tumoricidal M1-macrophages

(2019) Zhipeng Liu et al.   CANCER LETTERS

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

(2018) Chih-Sheng Chiang et al.   Nature Nanotechnology

Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4

(2018) Jun Ying et al.   Cell and Bioscience

Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1- profile in a TLR4-dependent manner

(2018) Carlos W Wanderley et al.   CANCER RESEARCH

Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin

(2018) Vivek K. Pawar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeting tumor associated macrophages: The new challenge for nanomedicine

(2017) Fernando Torres Andón et al.   SEMINARS IN IMMUNOLOGY

The Anti-Tumor Effects of M1 Macrophage-Loaded Poly (ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma

(2017) Alberto Daniel Guerra et al.   Theranostics

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

(2017) Li-Mei Chen et al.   Scientific Reports

Macrophages induce resistance to 5-fluorouracil chemotherapy in colorectal cancer through the release of putrescine

(2016) Xuan Zhang et al.   CANCER LETTERS

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

(2016) Mathias Wenes et al.   Cell Metabolism

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer

(2016) Jia Sun et al.   Scientific Reports

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy

(2015) Kristina Iribarren et al.   OncoImmunology

C/EBPα regulates macrophage activation and systemic metabolism

(2014) Bonggi Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Platelet-derived Growth Factor-C (PDGF-C) Induces Anti-apoptotic Effects on Macrophages through Akt and Bad Phosphorylation

(2014) Dain Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

(2014) Jun-O Jin et al.   PLoS One

Macrophages Are More Potent Immune Suppressors Ex Vivo Than Immature Myeloid-Derived Suppressor Cells Induced by Metastatic Murine Mammary Carcinomas

(2013) M. J. Hamilton et al.   JOURNAL OF IMMUNOLOGY

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Reactive oxygen species in TNFα-induced signaling and cell death

(2010) Michael J. Morgan et al.   MOLECULES AND CELLS

Combination of active specific immunotherapy or adoptive antibody or lymphocyte immunotherapy with chemotherapy in the treatment of cancer

(2008) Tianqian Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like receptors and immune regulation: implications for cancer therapy

(2008) R-F Wang et al.   ONCOGENE

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

(2007) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES