Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

Structural characterization and antitumor effects of fucoidans from brown algae Kjellmaniella crassifolia farmed in northern China

(2018) Yuefan Song et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo

(2018) Jiaxiu Yin et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats

(2018) Olga Pozharitskaya et al.   Marine Drugs

The Dual Role of Bone Morphogenetic Proteins in Cancer

(2018) Duc-Hiep Bach et al.   Molecular Therapy-Oncolytics

Current Landscape of Targeted Therapies for Hormone-Receptor Positive, HER2 Negative Metastatic Breast Cancer

(2018) Tarah J. Ballinger et al.   Frontiers in Oncology

Fucoidan-induced osteogenic differentiation promotes angiogenesis by inducing vascular endothelial growth factor secretion and accelerates bone repair

(2017) Beom-Su Kim et al.   Journal of Tissue Engineering and Regenerative Medicine

Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines

(2017) Michaela Dithmer et al.   Marine Drugs

Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1

(2017) Fanlu Wang et al.   Marine Drugs

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

(2017) Hye Park et al.   Marine Drugs

In vitro and in vivo anti-primary effusion lymphoma activities of fucoidan extracted from Cladosiphon okamuranus Tokida

(2017) Chie Ishikawa et al.   ONCOLOGY REPORTS

The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition

(2017) Varsha Thakur et al.   Oncotarget

Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

(2017) Hsien-Yeh Hsu et al.   Scientific Reports

The seasonal variation of fucoidan within three species of brown macroalgae

(2017) H.R. Fletcher et al.   Algal Research-Biomass Biofuels and Bioproducts

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

(2017) Michele Milella et al.   Scientific Reports

Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

(2017) Li-Mei Chen et al.   Scientific Reports

A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines

(2016) Jianqing Zhang et al.   BMC Complementary and Alternative Medicine

Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies

(2016) E.L. Andrade et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling

(2016) Huanjun Chen et al.   CANCER LETTERS

A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4

(2016) Wucheng Wang et al.   CARBOHYDRATE POLYMERS

A review about the development of fucoidan in antitumor activity: Progress and challenges

(2016) Lei Wu et al.   CARBOHYDRATE POLYMERS

Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme

(2016) Qifei Cong et al.   CARBOHYDRATE POLYMERS

Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway

(2016) Min Ho Han et al.   DRUG DEVELOPMENT RESEARCH

Characterization of ovarian cancer cell lines as in vivo models for preclinical studies

(2016) Lidia Hernandez et al.   GYNECOLOGIC ONCOLOGY

The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer

(2016) Shreya Tocaciu et al.   INTEGRATIVE CANCER THERAPIES

A mechanism of low molecular weight fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage

(2016) Pai-An Hwang et al.   JOURNAL OF APPLIED PHYCOLOGY

Bioactive properties and potentials cosmeceutical applications of phlorotannins isolated from brown seaweeds: A review

(2016) Kalu Kapuge Asanka Sanjeewa et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity

(2016) Catarina Oliveira et al.   MACROMOLECULAR BIOSCIENCE

Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression

(2016) Gang-Sik Choo et al.   Marine Drugs

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

(2016) Ludmylla Cunha et al.   Marine Drugs

Fucoidan inhibits angiogenesis induced by multiple myeloma cells

(2016) Fen Liu et al.   ONCOLOGY REPORTS

PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth

(2016) Olesia S. Vishchuk et al.   Oncotarget

Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells

(2016) Yazong Yang et al.   Oncotarget

Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice

(2016) Meng-Chuan Chen et al.   Oncotarget

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

(2016) Szu-Yuan Wu et al.   Journal of Cancer

Antitumor activity of fucoidan against diffuse large B cell lymphomain vitroandin vivo

(2015) Guang Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling

(2015) Yong-seok Han et al.   Biomolecules & Therapeutics

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Microanalysis and preliminary pharmacokinetic studies of a sulfated polysaccharide from Laminaria japonica

(2015) Wenjing Zhang et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

(2015) Pai-An Hwang et al.   CYTOTECHNOLOGY

Interference with the CXCL12/CXCR4 axis as potential antitumor strategy: superiority of a sulfated galactofucan from the brown algaSaccharina latissimaand Fucoidan over heparins

(2015) Tino Schneider et al.   GLYCOBIOLOGY

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused byHelicobacter pylori

(2015) Natalya N. Besednova et al.   HELICOBACTER

Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo

(2015) Farzaneh Atashrazm et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells

(2015) Ming-De Yan et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

Role of PTEN in neutrophil extracellular trap formation

(2015) Shahram Teimourian et al.   MOLECULAR IMMUNOLOGY

Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species

(2015) CHUNMEI WEI et al.   Molecular Medicine Reports

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

(2015) Akihiro Kasai et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells

(2015) Zhongyuan ZHANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucoidan Extracts Ameliorate Acute Colitis

(2015) Qi Ying Lean et al.   PLoS One

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

(2015) Hsien-Yeh Hsu et al.   Oncotarget

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines

(2014) EUN-YOUNG MIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

(2014) Jing Wang et al.   Marine Drugs

Intestinal Absorption of Fucoidan Extracted from the Brown Seaweed, Cladosiphon okamuranus

(2014) Takeaki Nagamine et al.   Marine Drugs

GNAQ and GNA11 mutations in uveal melanoma

(2014) Alexander N. Shoushtari et al.   MELANOMA RESEARCH

Structure and hypolipidaemic activity of fucoidan extracted from brown seaweedSargassum henslowianum

(2014) Ho Duc Cuong et al.   NATURAL PRODUCT RESEARCH

Fucoidan Reduces Secretion and Expression of Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium and Reduces Angiogenesis In Vitro

(2014) Michaela Dithmer et al.   PLoS One

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

(2014) Shaohua Chen et al.   PLoS One

Anti-Metastasis Effect of Fucoidan from Undaria pinnatifida Sporophylls in Mouse Hepatocarcinoma Hca-F Cells

(2014) Peisheng Wang et al.   PLoS One

Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer

(2014) Rosário Pinto-Leite et al.   TUMOR BIOLOGY

Fucoidan inhibits activation and receptor binding of transforming growth factor-β1

(2013) Tae Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Fucoidan from New Zealand Undaria pinnatifida: Monthly variations and determination of antioxidant activities

(2013) W. Mak et al.   CARBOHYDRATE POLYMERS

Mutations of theBRAFgene in human cancer, by Davieset al. (Nature2002; 417: 949-54)

(2013) G. W. M. Millington   CLINICAL AND EXPERIMENTAL DERMATOLOGY

AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells

(2013) Tae-Min Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

(2013) Kalimuthu Senthilkumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells

(2013) Amal M. Banafa et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

(2013) Hyun Park et al.   Marine Drugs

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Biogeography and biodiscovery hotspots of macroalgal marine natural products

(2013) Miguel C. Leal et al.   NATURAL PRODUCT REPORTS

Genetic inhibition of vascular endothelial growth factor receptor-1 significantly inhibits the migration and proliferation of leukemia cells and increases their sensitivity to chemotherapy

(2013) BING XIU et al.   ONCOLOGY REPORTS

Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

(2013) HANG-EUN LEE et al.   Experimental and Therapeutic Medicine

Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation

(2013) Marcel Tutor Ale et al.   RSC Advances

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

(2012) T. A. Yap et al.   CLINICAL CANCER RESEARCH

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Fucoidan prevents multiple myeloma cell escape from chemotherapy-induced drug cytotoxicity

(2012) Jinglong Lv et al.   FITOTERAPIA

Correction to An Unfractionated Fucoidan from Ascophyllum nodosum: Extraction, Characterization, and Apoptotic Effects in Vitro

(2012) Sarah A. Foley et al.   JOURNAL OF NATURAL PRODUCTS

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways

(2012) Hyunkyoung Lee et al.   PLoS One

PI3-K/Akt/JNK/NF-κB is essential for MMP-9 expression and outgrowth in human limbal epithelial cells on intact amniotic membrane

(2012) Ching-Yi Cheng et al.   Stem Cell Research

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

(2011) Sang-Won HONG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Brown algae

(2011) J. Mark Cock et al.   CURRENT BIOLOGY

In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype

(2011) Birgit Hotz et al.   Gastric Cancer

Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?

(2011) Yevgeniya J. Ioffe et al.   GYNECOLOGIC ONCOLOGY

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Designed optimization of a single-step extraction of fucose-containing sulfated polysaccharides from Sargassum sp.

(2011) Marcel Tutor Ale et al.   JOURNAL OF APPLIED PHYCOLOGY

Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro

(2011) Marcel Tutor Ale et al.   Marine Drugs

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Development of a Fucoidan-Specific Antibody and Measurement of Fucoidan in Serum and Urine by Sandwich ELISA

(2010) Yoshiharu TOKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Fucoidan present in brown algae induces apoptosis of human colon cancer cells

(2010) Eun Ji Kim et al.   BMC GASTROENTEROLOGY

Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

(2010) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

Clinical significance of tumor suppressor PTEN in colorectal carcinoma

(2010) C.P. Hsu et al.   EJSO

Genotoxicity studies on fucoidan from Sporophyll of Undaria pinnatifida

(2010) Kui-Jin Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

(2010) Myoung Lae Cho et al.   MOLECULES

Activity of MMP-2 and MMP-9 in sera of breast cancer patients

(2010) Sandra Stankovic et al.   PATHOLOGY RESEARCH AND PRACTICE

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

(2010) Y. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switching Akt: from survival signaling to deadly response

(2009) Marek Los et al.   BIOESSAYS

Apoptosis Inducing Activity of Fucoidan in HCT-15 Colon Carcinoma Cells

(2009) Jae-Hee Hyun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer

(2009) X B Trinh et al.   BRITISH JOURNAL OF CANCER

Analysis of the monosaccharide composition of fucoidan by precolumn derivation HPLC

(2009) Jingjing Zhang et al.   CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY

Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: The crucial role of PTEN

(2009) Cristina Cellai et al.   EXPERIMENTAL HEMATOLOGY

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Beneficial effects of fucoidan on osteoblastic MG-63 cell differentiation

(2009) Young-Sook Cho et al.   FOOD CHEMISTRY

Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells

(2009) Yumi Yamasaki-Miyamoto et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect ofCostaria costataFucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, and Protein

(2009) Hee Jung Moon et al.   JOURNAL OF NATURAL PRODUCTS

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

(2009) Kui-Jin Kim et al.   TOXICOLOGY

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

(2008) Veronique Nogueira et al.   CANCER CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES