Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression

Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer

(2017) Hsien-Yeh Hsu et al.   Scientific Reports

Oligo-fucoidan prevents renal tubulointerstitial fibrosis by inhibiting the CD44 signal pathway

(2017) Cheng-Hsien Chen et al.   Scientific Reports

Cytokines in cancer drug resistance: Cues to new therapeutic strategies

(2016) Valerie Sloane Jones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A mechanism of low molecular weight fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage

(2016) Pai-An Hwang et al.   JOURNAL OF APPLIED PHYCOLOGY

The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells

(2016) Chao-Huei Yang et al.   Marine Drugs

Fucoidan as a Potential Therapeutic for Major Blinding Diseases—A Hypothesis

(2016) Alexa Klettner   Marine Drugs

Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases

(2016) Kenneth Collins et al.   Marine Drugs

Fucoidan reduces oxidative stress by regulating the gene expression of HO-1 and SOD-1 through the Nrf2/ERK signaling pathway in HaCaT cells

(2016) Min Ju Ryu et al.   Molecular Medicine Reports

Combined administration of fucoidan ameliorates tumor and chemotherapy-induced skeletal muscle atrophy in bladder cancer-bearing mice

(2016) Meng-Chuan Chen et al.   Oncotarget

Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells

(2016) Pai-An Hwang et al.   Food & Nutrition Research

DNA Repair and Cytokines: TGF-β, IL-6, and Thrombopoietin as Different Biomarkers of Radioresistance

(2016) Lucia Centurione et al.   Frontiers in Oncology

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Etoposide induces cell death via mitochondrial-dependent actions of p53

(2015) Sarwat Jamil et al.   Cancer Cell International

Chk1 and Wee1 control genotoxic-stress induced G2–M arrest in melanoma cells

(2015) Julio Vera et al.   CELLULAR SIGNALLING

The in vitro and in vivo effects of the low molecular weight fucoidan on the bone osteogenic differentiation properties

(2015) Pai-An Hwang et al.   CYTOTECHNOLOGY

Fucoidan from Turbinaria conoides: A multifaceted ‘deliverable’ to combat pancreatic cancer progression

(2015) Caroline R. Delma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan delays apoptosis and induces pro-inflammatory cytokine production in human neutrophils

(2015) Jun-O Jin et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Therapies from Fucoidan: An Update

(2015) Janet Fitton et al.   Marine Drugs

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells

(2015) Ming-De Yan et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

(2015) Meng-Chuan Chen et al.   Marine Drugs

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

The role of seaweed bioactives in the control of digestion: implications for obesity treatments

(2015) Peter I. Chater et al.   Food & Function

Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation

(2015) Hsien-Yeh Hsu et al.   Oncotarget

Fucoidans: Pro- or antiangiogenic agents?

(2014) N. E. Ustyuzhanina et al.   GLYCOBIOLOGY

The CCL2/CCR2 axis enhances IL-6-induced epithelial-mesenchymal transition by cooperatively activating STAT3-Twist signaling

(2014) Wei Chen et al.   TUMOR BIOLOGY

Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

(2013) S Mitsunaga et al.   BRITISH JOURNAL OF CANCER

Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma

(2013) Tasnim Ara et al.   CANCER RESEARCH

The Anticancer Effect of Fucoidan in PC-3 Prostate Cancer Cells

(2013) Hye-Jin Boo et al.   Marine Drugs

Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling

(2013) Meilan Xue et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway

(2012) Monika Julia Wolf et al.   CANCER CELL

DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors

(2012) Un Jung Yun et al.   CANCER LETTERS

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF  receptor degradation in breast cancer

(2012) H.-Y. Hsu et al.   CARCINOGENESIS

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

(2012) Fang Liu et al.   PHYTOMEDICINE

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

Fucoidans as a natural bioactive ingredient for functional foods

(2012) Thanh-Sang Vo et al.   Journal of Functional Foods

Suppression by Fucoidan of Liver Fibrogenesisviathe TGF-β/Smad Pathway in Protecting against Oxidative Stress

(2011) Sang-Won HONG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells

(2011) Hye Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

(2011) Marcel Tutor Ale et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan Extract Induces Apoptosis in MCF-7 Cells via a Mechanism Involving the ROS-Dependent JNK Activation and Mitochondria-Mediated Pathways

(2011) Zhongyuan Zhang et al.   PLoS One

Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells

(2010) Yaling Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds

(2008) Mikhail Kusaykin et al.   Biotechnology Journal

Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A

(2008) M. Narazaki et al.   BLOOD

Fucoidan: Structure and Bioactivity

(2008) Bo Li et al.   MOLECULES

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

(2007) Jing Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES